Histophilus somni-associated syndromes in sheep from Southern Brazil
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Brazilian Journal of Microbiology |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822018000300591 |
Resumo: | Abstract Histophilus somni is a Gram-negative bacterium that is associated with a disease complex (termed histophilosis) that can produce several clinical syndromes predominantly in cattle, but also in sheep. Histophilosis is well described in North America, Canada, and in some European countries. In Brazil, histophilosis has been described in cattle with respiratory, reproductive, and systemic disease, with only one case described in sheep. This report describes the occurrence of Histophilus somni-associated disease in sheep from Southern Brazil. Eight sheep with different clinical manifestations from five farms were investigated by a combination of pathological and molecular diagnostic methods to identify additional cases of histophilosis in sheep from Brazil. The principal pathological lesions were thrombotic meningoencephalitis, fibrinous bronchopneumonia, pulmonary abscesses, and necrotizing myocarditis. The main clinical syndromes associated with H. somni were thrombotic meningoencephalitis (n = 4), septicemia (n = 4), bronchopneumonia (n = 4), and myocarditis (n = 3). H. somni DNA was amplified from multiple tissues of all sheep with clinical syndromes of histophilosis; sequencing confirmed the PCR results. Further, PCR assays to detect Pasteurella multocida and Mannheimia haemolytica were negative. These findings confirmed the participation of H. somni in the clinical syndromes investigated during this study, and adds to the previous report of histophilosis in sheep from Brazil. |
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Brazilian Journal of Microbiology |
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Histophilus somni-associated syndromes in sheep from Southern BrazilHistophilosisMolecular testingBronchopneumoniaMyocarditisThrombotic meningoencephalitisAbstract Histophilus somni is a Gram-negative bacterium that is associated with a disease complex (termed histophilosis) that can produce several clinical syndromes predominantly in cattle, but also in sheep. Histophilosis is well described in North America, Canada, and in some European countries. In Brazil, histophilosis has been described in cattle with respiratory, reproductive, and systemic disease, with only one case described in sheep. This report describes the occurrence of Histophilus somni-associated disease in sheep from Southern Brazil. Eight sheep with different clinical manifestations from five farms were investigated by a combination of pathological and molecular diagnostic methods to identify additional cases of histophilosis in sheep from Brazil. The principal pathological lesions were thrombotic meningoencephalitis, fibrinous bronchopneumonia, pulmonary abscesses, and necrotizing myocarditis. The main clinical syndromes associated with H. somni were thrombotic meningoencephalitis (n = 4), septicemia (n = 4), bronchopneumonia (n = 4), and myocarditis (n = 3). H. somni DNA was amplified from multiple tissues of all sheep with clinical syndromes of histophilosis; sequencing confirmed the PCR results. Further, PCR assays to detect Pasteurella multocida and Mannheimia haemolytica were negative. These findings confirmed the participation of H. somni in the clinical syndromes investigated during this study, and adds to the previous report of histophilosis in sheep from Brazil.Sociedade Brasileira de Microbiologia2018-09-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822018000300591Brazilian Journal of Microbiology v.49 n.3 2018reponame:Brazilian Journal of Microbiologyinstname:Sociedade Brasileira de Microbiologia (SBM)instacron:SBM10.1016/j.bjm.2017.12.008info:eu-repo/semantics/openAccessHeadley,Selwyn A.Pereira,Alfredo H.T.Balbo,Luciana C.Santia,Giovana W. DiBracarense,Ana P.F.R.L.Cunha Filho,Luiz F.C.Schade,JacksonOkano,WernerPereira,Priscilla F.V.Morotti,FábioPreto-Giordano,Lucienne G.Marcasso,Rogério A.Alfieri,Alice F.Lisbôa,Júlio A.N.Alfieri,Amauri A.eng2018-08-03T00:00:00Zoai:scielo:S1517-83822018000300591Revistahttps://www.scielo.br/j/bjm/ONGhttps://old.scielo.br/oai/scielo-oai.phpbjm@sbmicrobiologia.org.br||mbmartin@usp.br1678-44051517-8382opendoar:2018-08-03T00:00Brazilian Journal of Microbiology - Sociedade Brasileira de Microbiologia (SBM)false |
dc.title.none.fl_str_mv |
Histophilus somni-associated syndromes in sheep from Southern Brazil |
title |
Histophilus somni-associated syndromes in sheep from Southern Brazil |
spellingShingle |
Histophilus somni-associated syndromes in sheep from Southern Brazil Headley,Selwyn A. Histophilosis Molecular testing Bronchopneumonia Myocarditis Thrombotic meningoencephalitis |
title_short |
Histophilus somni-associated syndromes in sheep from Southern Brazil |
title_full |
Histophilus somni-associated syndromes in sheep from Southern Brazil |
title_fullStr |
Histophilus somni-associated syndromes in sheep from Southern Brazil |
title_full_unstemmed |
Histophilus somni-associated syndromes in sheep from Southern Brazil |
title_sort |
Histophilus somni-associated syndromes in sheep from Southern Brazil |
author |
Headley,Selwyn A. |
author_facet |
Headley,Selwyn A. Pereira,Alfredo H.T. Balbo,Luciana C. Santia,Giovana W. Di Bracarense,Ana P.F.R.L. Cunha Filho,Luiz F.C. Schade,Jackson Okano,Werner Pereira,Priscilla F.V. Morotti,Fábio Preto-Giordano,Lucienne G. Marcasso,Rogério A. Alfieri,Alice F. Lisbôa,Júlio A.N. Alfieri,Amauri A. |
author_role |
author |
author2 |
Pereira,Alfredo H.T. Balbo,Luciana C. Santia,Giovana W. Di Bracarense,Ana P.F.R.L. Cunha Filho,Luiz F.C. Schade,Jackson Okano,Werner Pereira,Priscilla F.V. Morotti,Fábio Preto-Giordano,Lucienne G. Marcasso,Rogério A. Alfieri,Alice F. Lisbôa,Júlio A.N. Alfieri,Amauri A. |
author2_role |
author author author author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Headley,Selwyn A. Pereira,Alfredo H.T. Balbo,Luciana C. Santia,Giovana W. Di Bracarense,Ana P.F.R.L. Cunha Filho,Luiz F.C. Schade,Jackson Okano,Werner Pereira,Priscilla F.V. Morotti,Fábio Preto-Giordano,Lucienne G. Marcasso,Rogério A. Alfieri,Alice F. Lisbôa,Júlio A.N. Alfieri,Amauri A. |
dc.subject.por.fl_str_mv |
Histophilosis Molecular testing Bronchopneumonia Myocarditis Thrombotic meningoencephalitis |
topic |
Histophilosis Molecular testing Bronchopneumonia Myocarditis Thrombotic meningoencephalitis |
description |
Abstract Histophilus somni is a Gram-negative bacterium that is associated with a disease complex (termed histophilosis) that can produce several clinical syndromes predominantly in cattle, but also in sheep. Histophilosis is well described in North America, Canada, and in some European countries. In Brazil, histophilosis has been described in cattle with respiratory, reproductive, and systemic disease, with only one case described in sheep. This report describes the occurrence of Histophilus somni-associated disease in sheep from Southern Brazil. Eight sheep with different clinical manifestations from five farms were investigated by a combination of pathological and molecular diagnostic methods to identify additional cases of histophilosis in sheep from Brazil. The principal pathological lesions were thrombotic meningoencephalitis, fibrinous bronchopneumonia, pulmonary abscesses, and necrotizing myocarditis. The main clinical syndromes associated with H. somni were thrombotic meningoencephalitis (n = 4), septicemia (n = 4), bronchopneumonia (n = 4), and myocarditis (n = 3). H. somni DNA was amplified from multiple tissues of all sheep with clinical syndromes of histophilosis; sequencing confirmed the PCR results. Further, PCR assays to detect Pasteurella multocida and Mannheimia haemolytica were negative. These findings confirmed the participation of H. somni in the clinical syndromes investigated during this study, and adds to the previous report of histophilosis in sheep from Brazil. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-09-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822018000300591 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822018000300591 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1016/j.bjm.2017.12.008 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Microbiologia |
publisher.none.fl_str_mv |
Sociedade Brasileira de Microbiologia |
dc.source.none.fl_str_mv |
Brazilian Journal of Microbiology v.49 n.3 2018 reponame:Brazilian Journal of Microbiology instname:Sociedade Brasileira de Microbiologia (SBM) instacron:SBM |
instname_str |
Sociedade Brasileira de Microbiologia (SBM) |
instacron_str |
SBM |
institution |
SBM |
reponame_str |
Brazilian Journal of Microbiology |
collection |
Brazilian Journal of Microbiology |
repository.name.fl_str_mv |
Brazilian Journal of Microbiology - Sociedade Brasileira de Microbiologia (SBM) |
repository.mail.fl_str_mv |
bjm@sbmicrobiologia.org.br||mbmartin@usp.br |
_version_ |
1752122209719025664 |