Boosting the suppressive effects of Ascaris suum components in IFN-γ-deficient mice

Detalhes bibliográficos
Autor(a) principal: Souza,Valdênia Maria Oliveira
Data de Publicação: 2009
Outros Autores: Macedo,Mahasti Sahihi
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Revista da Sociedade Brasileira de Medicina Tropical
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822009000300021
Resumo: High molecular weight components from Ascaris suum extract suppress ovalbumin-specific immunity in mice. In IFN-γ-deficient mice, ovalbumin-specific delayed-type hypersensitivity reactions are more strongly downregulated by these suppressive components. Here, the cellularity of the delayed-type hypersensitivity reaction in IFN-γ-deficient mice and the increased downregulation induced by Ascaris suum components were analyzed. IL-12p40-dependent neutrophilic influx was predominant. Suboptimal doses of the suppressive fraction from this nematode completely inhibited the hypersensitivity reaction, thus indicating intensification of the immunosuppression under conditions of intense recruitment of IFN-γ-independent neutrophils.
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spelling Boosting the suppressive effects of Ascaris suum components in IFN-γ-deficient miceAscaris suumDelayed-type hypersensitivityImmunosuppressionIFN-γ-deficient miceNeutrophilHigh molecular weight components from Ascaris suum extract suppress ovalbumin-specific immunity in mice. In IFN-γ-deficient mice, ovalbumin-specific delayed-type hypersensitivity reactions are more strongly downregulated by these suppressive components. Here, the cellularity of the delayed-type hypersensitivity reaction in IFN-γ-deficient mice and the increased downregulation induced by Ascaris suum components were analyzed. IL-12p40-dependent neutrophilic influx was predominant. Suboptimal doses of the suppressive fraction from this nematode completely inhibited the hypersensitivity reaction, thus indicating intensification of the immunosuppression under conditions of intense recruitment of IFN-γ-independent neutrophils.Sociedade Brasileira de Medicina Tropical - SBMT2009-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822009000300021Revista da Sociedade Brasileira de Medicina Tropical v.42 n.3 2009reponame:Revista da Sociedade Brasileira de Medicina Tropicalinstname:Sociedade Brasileira de Medicina Tropical (SBMT)instacron:SBMT10.1590/S0037-86822009000300021info:eu-repo/semantics/openAccessSouza,Valdênia Maria OliveiraMacedo,Mahasti Sahihieng2009-08-10T00:00:00Zoai:scielo:S0037-86822009000300021Revistahttps://www.sbmt.org.br/portal/revista/ONGhttps://old.scielo.br/oai/scielo-oai.php||dalmo@rsbmt.uftm.edu.br|| rsbmt@rsbmt.uftm.edu.br1678-98490037-8682opendoar:2009-08-10T00:00Revista da Sociedade Brasileira de Medicina Tropical - Sociedade Brasileira de Medicina Tropical (SBMT)false
dc.title.none.fl_str_mv Boosting the suppressive effects of Ascaris suum components in IFN-γ-deficient mice
title Boosting the suppressive effects of Ascaris suum components in IFN-γ-deficient mice
spellingShingle Boosting the suppressive effects of Ascaris suum components in IFN-γ-deficient mice
Souza,Valdênia Maria Oliveira
Ascaris suum
Delayed-type hypersensitivity
Immunosuppression
IFN-γ-deficient mice
Neutrophil
title_short Boosting the suppressive effects of Ascaris suum components in IFN-γ-deficient mice
title_full Boosting the suppressive effects of Ascaris suum components in IFN-γ-deficient mice
title_fullStr Boosting the suppressive effects of Ascaris suum components in IFN-γ-deficient mice
title_full_unstemmed Boosting the suppressive effects of Ascaris suum components in IFN-γ-deficient mice
title_sort Boosting the suppressive effects of Ascaris suum components in IFN-γ-deficient mice
author Souza,Valdênia Maria Oliveira
author_facet Souza,Valdênia Maria Oliveira
Macedo,Mahasti Sahihi
author_role author
author2 Macedo,Mahasti Sahihi
author2_role author
dc.contributor.author.fl_str_mv Souza,Valdênia Maria Oliveira
Macedo,Mahasti Sahihi
dc.subject.por.fl_str_mv Ascaris suum
Delayed-type hypersensitivity
Immunosuppression
IFN-γ-deficient mice
Neutrophil
topic Ascaris suum
Delayed-type hypersensitivity
Immunosuppression
IFN-γ-deficient mice
Neutrophil
description High molecular weight components from Ascaris suum extract suppress ovalbumin-specific immunity in mice. In IFN-γ-deficient mice, ovalbumin-specific delayed-type hypersensitivity reactions are more strongly downregulated by these suppressive components. Here, the cellularity of the delayed-type hypersensitivity reaction in IFN-γ-deficient mice and the increased downregulation induced by Ascaris suum components were analyzed. IL-12p40-dependent neutrophilic influx was predominant. Suboptimal doses of the suppressive fraction from this nematode completely inhibited the hypersensitivity reaction, thus indicating intensification of the immunosuppression under conditions of intense recruitment of IFN-γ-independent neutrophils.
publishDate 2009
dc.date.none.fl_str_mv 2009-06-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822009000300021
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822009000300021
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0037-86822009000300021
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Medicina Tropical - SBMT
publisher.none.fl_str_mv Sociedade Brasileira de Medicina Tropical - SBMT
dc.source.none.fl_str_mv Revista da Sociedade Brasileira de Medicina Tropical v.42 n.3 2009
reponame:Revista da Sociedade Brasileira de Medicina Tropical
instname:Sociedade Brasileira de Medicina Tropical (SBMT)
instacron:SBMT
instname_str Sociedade Brasileira de Medicina Tropical (SBMT)
instacron_str SBMT
institution SBMT
reponame_str Revista da Sociedade Brasileira de Medicina Tropical
collection Revista da Sociedade Brasileira de Medicina Tropical
repository.name.fl_str_mv Revista da Sociedade Brasileira de Medicina Tropical - Sociedade Brasileira de Medicina Tropical (SBMT)
repository.mail.fl_str_mv ||dalmo@rsbmt.uftm.edu.br|| rsbmt@rsbmt.uftm.edu.br
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