Boosting the suppressive effects of Ascaris suum components in IFN-γ-deficient mice
Autor(a) principal: | |
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Data de Publicação: | 2009 |
Outros Autores: | |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Revista da Sociedade Brasileira de Medicina Tropical |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822009000300021 |
Resumo: | High molecular weight components from Ascaris suum extract suppress ovalbumin-specific immunity in mice. In IFN-γ-deficient mice, ovalbumin-specific delayed-type hypersensitivity reactions are more strongly downregulated by these suppressive components. Here, the cellularity of the delayed-type hypersensitivity reaction in IFN-γ-deficient mice and the increased downregulation induced by Ascaris suum components were analyzed. IL-12p40-dependent neutrophilic influx was predominant. Suboptimal doses of the suppressive fraction from this nematode completely inhibited the hypersensitivity reaction, thus indicating intensification of the immunosuppression under conditions of intense recruitment of IFN-γ-independent neutrophils. |
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Revista da Sociedade Brasileira de Medicina Tropical |
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Boosting the suppressive effects of Ascaris suum components in IFN-γ-deficient miceAscaris suumDelayed-type hypersensitivityImmunosuppressionIFN-γ-deficient miceNeutrophilHigh molecular weight components from Ascaris suum extract suppress ovalbumin-specific immunity in mice. In IFN-γ-deficient mice, ovalbumin-specific delayed-type hypersensitivity reactions are more strongly downregulated by these suppressive components. Here, the cellularity of the delayed-type hypersensitivity reaction in IFN-γ-deficient mice and the increased downregulation induced by Ascaris suum components were analyzed. IL-12p40-dependent neutrophilic influx was predominant. Suboptimal doses of the suppressive fraction from this nematode completely inhibited the hypersensitivity reaction, thus indicating intensification of the immunosuppression under conditions of intense recruitment of IFN-γ-independent neutrophils.Sociedade Brasileira de Medicina Tropical - SBMT2009-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822009000300021Revista da Sociedade Brasileira de Medicina Tropical v.42 n.3 2009reponame:Revista da Sociedade Brasileira de Medicina Tropicalinstname:Sociedade Brasileira de Medicina Tropical (SBMT)instacron:SBMT10.1590/S0037-86822009000300021info:eu-repo/semantics/openAccessSouza,Valdênia Maria OliveiraMacedo,Mahasti Sahihieng2009-08-10T00:00:00Zoai:scielo:S0037-86822009000300021Revistahttps://www.sbmt.org.br/portal/revista/ONGhttps://old.scielo.br/oai/scielo-oai.php||dalmo@rsbmt.uftm.edu.br|| rsbmt@rsbmt.uftm.edu.br1678-98490037-8682opendoar:2009-08-10T00:00Revista da Sociedade Brasileira de Medicina Tropical - Sociedade Brasileira de Medicina Tropical (SBMT)false |
dc.title.none.fl_str_mv |
Boosting the suppressive effects of Ascaris suum components in IFN-γ-deficient mice |
title |
Boosting the suppressive effects of Ascaris suum components in IFN-γ-deficient mice |
spellingShingle |
Boosting the suppressive effects of Ascaris suum components in IFN-γ-deficient mice Souza,Valdênia Maria Oliveira Ascaris suum Delayed-type hypersensitivity Immunosuppression IFN-γ-deficient mice Neutrophil |
title_short |
Boosting the suppressive effects of Ascaris suum components in IFN-γ-deficient mice |
title_full |
Boosting the suppressive effects of Ascaris suum components in IFN-γ-deficient mice |
title_fullStr |
Boosting the suppressive effects of Ascaris suum components in IFN-γ-deficient mice |
title_full_unstemmed |
Boosting the suppressive effects of Ascaris suum components in IFN-γ-deficient mice |
title_sort |
Boosting the suppressive effects of Ascaris suum components in IFN-γ-deficient mice |
author |
Souza,Valdênia Maria Oliveira |
author_facet |
Souza,Valdênia Maria Oliveira Macedo,Mahasti Sahihi |
author_role |
author |
author2 |
Macedo,Mahasti Sahihi |
author2_role |
author |
dc.contributor.author.fl_str_mv |
Souza,Valdênia Maria Oliveira Macedo,Mahasti Sahihi |
dc.subject.por.fl_str_mv |
Ascaris suum Delayed-type hypersensitivity Immunosuppression IFN-γ-deficient mice Neutrophil |
topic |
Ascaris suum Delayed-type hypersensitivity Immunosuppression IFN-γ-deficient mice Neutrophil |
description |
High molecular weight components from Ascaris suum extract suppress ovalbumin-specific immunity in mice. In IFN-γ-deficient mice, ovalbumin-specific delayed-type hypersensitivity reactions are more strongly downregulated by these suppressive components. Here, the cellularity of the delayed-type hypersensitivity reaction in IFN-γ-deficient mice and the increased downregulation induced by Ascaris suum components were analyzed. IL-12p40-dependent neutrophilic influx was predominant. Suboptimal doses of the suppressive fraction from this nematode completely inhibited the hypersensitivity reaction, thus indicating intensification of the immunosuppression under conditions of intense recruitment of IFN-γ-independent neutrophils. |
publishDate |
2009 |
dc.date.none.fl_str_mv |
2009-06-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822009000300021 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822009000300021 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0037-86822009000300021 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Medicina Tropical - SBMT |
publisher.none.fl_str_mv |
Sociedade Brasileira de Medicina Tropical - SBMT |
dc.source.none.fl_str_mv |
Revista da Sociedade Brasileira de Medicina Tropical v.42 n.3 2009 reponame:Revista da Sociedade Brasileira de Medicina Tropical instname:Sociedade Brasileira de Medicina Tropical (SBMT) instacron:SBMT |
instname_str |
Sociedade Brasileira de Medicina Tropical (SBMT) |
instacron_str |
SBMT |
institution |
SBMT |
reponame_str |
Revista da Sociedade Brasileira de Medicina Tropical |
collection |
Revista da Sociedade Brasileira de Medicina Tropical |
repository.name.fl_str_mv |
Revista da Sociedade Brasileira de Medicina Tropical - Sociedade Brasileira de Medicina Tropical (SBMT) |
repository.mail.fl_str_mv |
||dalmo@rsbmt.uftm.edu.br|| rsbmt@rsbmt.uftm.edu.br |
_version_ |
1752122155237113856 |