An alternative antimonial schedule to be used in cutaneous leishmaniasis when high doses of antimony are undesirable
Autor(a) principal: | |
---|---|
Data de Publicação: | 2006 |
Outros Autores: | |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Revista da Sociedade Brasileira de Medicina Tropical |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822006000400001 |
Resumo: | Despite more than half a century of use in leishmaniasis, antimony therapy still presents serious problems concerning dosage and toxicity. Low and high doses have been shown to be equally effective. In this paper, the feasibility of injecting one ampoule of meglumine antimoniate intramuscularly every other day until clinical cure is demonstrated, while studying a series of 40 cutaneous leishmaniasis cases. Total dose used varied from 1,822.5 to 12,150mg of pentavalent antimony and total time of treatment varied from 3 to 10 weeks, with 86% efficacy. Thirty-six out of the 40 patients are still on follow-up with a mean time of 10.7 ± 7 months and a median of 9 months. No relapse or mucosal lesions have been noted so far. The schedule showed good tolerance and easy application and its efficacy was comparable to the officially recommended WHO schedule. Therefore, such a schedule represents a valuable alternative for the cases with high toxicicity to antimony or daily injections are an obstacle to the treatment. |
id |
SBMT-1_8b3b447843e587a22571e1aa482df406 |
---|---|
oai_identifier_str |
oai:scielo:S0037-86822006000400001 |
network_acronym_str |
SBMT-1 |
network_name_str |
Revista da Sociedade Brasileira de Medicina Tropical |
repository_id_str |
|
spelling |
An alternative antimonial schedule to be used in cutaneous leishmaniasis when high doses of antimony are undesirableCutaneous leishmaniasisPentavalent antimonyLow doseSystemic therapyDespite more than half a century of use in leishmaniasis, antimony therapy still presents serious problems concerning dosage and toxicity. Low and high doses have been shown to be equally effective. In this paper, the feasibility of injecting one ampoule of meglumine antimoniate intramuscularly every other day until clinical cure is demonstrated, while studying a series of 40 cutaneous leishmaniasis cases. Total dose used varied from 1,822.5 to 12,150mg of pentavalent antimony and total time of treatment varied from 3 to 10 weeks, with 86% efficacy. Thirty-six out of the 40 patients are still on follow-up with a mean time of 10.7 ± 7 months and a median of 9 months. No relapse or mucosal lesions have been noted so far. The schedule showed good tolerance and easy application and its efficacy was comparable to the officially recommended WHO schedule. Therefore, such a schedule represents a valuable alternative for the cases with high toxicicity to antimony or daily injections are an obstacle to the treatment.Sociedade Brasileira de Medicina Tropical - SBMT2006-08-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822006000400001Revista da Sociedade Brasileira de Medicina Tropical v.39 n.4 2006reponame:Revista da Sociedade Brasileira de Medicina Tropicalinstname:Sociedade Brasileira de Medicina Tropical (SBMT)instacron:SBMT10.1590/S0037-86822006000400001info:eu-repo/semantics/openAccessOliveira-Neto,Manoel Paes deMattos,Marise da Silvaeng2006-09-25T00:00:00Zoai:scielo:S0037-86822006000400001Revistahttps://www.sbmt.org.br/portal/revista/ONGhttps://old.scielo.br/oai/scielo-oai.php||dalmo@rsbmt.uftm.edu.br|| rsbmt@rsbmt.uftm.edu.br1678-98490037-8682opendoar:2006-09-25T00:00Revista da Sociedade Brasileira de Medicina Tropical - Sociedade Brasileira de Medicina Tropical (SBMT)false |
dc.title.none.fl_str_mv |
An alternative antimonial schedule to be used in cutaneous leishmaniasis when high doses of antimony are undesirable |
title |
An alternative antimonial schedule to be used in cutaneous leishmaniasis when high doses of antimony are undesirable |
spellingShingle |
An alternative antimonial schedule to be used in cutaneous leishmaniasis when high doses of antimony are undesirable Oliveira-Neto,Manoel Paes de Cutaneous leishmaniasis Pentavalent antimony Low dose Systemic therapy |
title_short |
An alternative antimonial schedule to be used in cutaneous leishmaniasis when high doses of antimony are undesirable |
title_full |
An alternative antimonial schedule to be used in cutaneous leishmaniasis when high doses of antimony are undesirable |
title_fullStr |
An alternative antimonial schedule to be used in cutaneous leishmaniasis when high doses of antimony are undesirable |
title_full_unstemmed |
An alternative antimonial schedule to be used in cutaneous leishmaniasis when high doses of antimony are undesirable |
title_sort |
An alternative antimonial schedule to be used in cutaneous leishmaniasis when high doses of antimony are undesirable |
author |
Oliveira-Neto,Manoel Paes de |
author_facet |
Oliveira-Neto,Manoel Paes de Mattos,Marise da Silva |
author_role |
author |
author2 |
Mattos,Marise da Silva |
author2_role |
author |
dc.contributor.author.fl_str_mv |
Oliveira-Neto,Manoel Paes de Mattos,Marise da Silva |
dc.subject.por.fl_str_mv |
Cutaneous leishmaniasis Pentavalent antimony Low dose Systemic therapy |
topic |
Cutaneous leishmaniasis Pentavalent antimony Low dose Systemic therapy |
description |
Despite more than half a century of use in leishmaniasis, antimony therapy still presents serious problems concerning dosage and toxicity. Low and high doses have been shown to be equally effective. In this paper, the feasibility of injecting one ampoule of meglumine antimoniate intramuscularly every other day until clinical cure is demonstrated, while studying a series of 40 cutaneous leishmaniasis cases. Total dose used varied from 1,822.5 to 12,150mg of pentavalent antimony and total time of treatment varied from 3 to 10 weeks, with 86% efficacy. Thirty-six out of the 40 patients are still on follow-up with a mean time of 10.7 ± 7 months and a median of 9 months. No relapse or mucosal lesions have been noted so far. The schedule showed good tolerance and easy application and its efficacy was comparable to the officially recommended WHO schedule. Therefore, such a schedule represents a valuable alternative for the cases with high toxicicity to antimony or daily injections are an obstacle to the treatment. |
publishDate |
2006 |
dc.date.none.fl_str_mv |
2006-08-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822006000400001 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822006000400001 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0037-86822006000400001 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Medicina Tropical - SBMT |
publisher.none.fl_str_mv |
Sociedade Brasileira de Medicina Tropical - SBMT |
dc.source.none.fl_str_mv |
Revista da Sociedade Brasileira de Medicina Tropical v.39 n.4 2006 reponame:Revista da Sociedade Brasileira de Medicina Tropical instname:Sociedade Brasileira de Medicina Tropical (SBMT) instacron:SBMT |
instname_str |
Sociedade Brasileira de Medicina Tropical (SBMT) |
instacron_str |
SBMT |
institution |
SBMT |
reponame_str |
Revista da Sociedade Brasileira de Medicina Tropical |
collection |
Revista da Sociedade Brasileira de Medicina Tropical |
repository.name.fl_str_mv |
Revista da Sociedade Brasileira de Medicina Tropical - Sociedade Brasileira de Medicina Tropical (SBMT) |
repository.mail.fl_str_mv |
||dalmo@rsbmt.uftm.edu.br|| rsbmt@rsbmt.uftm.edu.br |
_version_ |
1752122153583509504 |