Experimental ophitoxemia produced by the opisthoglyphous lora snake (Philodryas olfersii) venom

Detalhes bibliográficos
Autor(a) principal: Rodríguez-Acosta,Alexis
Data de Publicação: 2006
Outros Autores: Lemoine,Karel, Navarrete,Luis, Girón,María E., Aguilar,Irma
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Revista da Sociedade Brasileira de Medicina Tropical
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822006000200012
Resumo: Several colubrid snakes produce venomous oral secretions. In this work, the venom collected from Venezuelan opisthoglyphous (rear-fanged) Philodryas olfersii snake was studied. Different proteins were present in its venom and they were characterized by 20% SDS-PAGE protein electrophoresis. The secretion exhibited proteolytic (gelatinase) activity, which was partially purified on a chromatography ionic exchange mono Q2 column. Additionally, the haemorrhagic activity of Philodryas olfersii venom on chicken embryos, mouse skin and peritoneum was demonstrated. Neurotoxic symptoms were demonstrated in mice inoculated with Philodryas olfersii venom. In conclusion, Philodryas olfersii venom showed proteolytic, haemorrhagic, and neurotoxic activities, thus increasing the interest in the high toxic action of Philodryas venom.
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spelling Experimental ophitoxemia produced by the opisthoglyphous lora snake (Philodryas olfersii) venomColubridaeHaemorrhageNeurotoxicPhilodryas olfersiiProteolytic activityVenomSeveral colubrid snakes produce venomous oral secretions. In this work, the venom collected from Venezuelan opisthoglyphous (rear-fanged) Philodryas olfersii snake was studied. Different proteins were present in its venom and they were characterized by 20% SDS-PAGE protein electrophoresis. The secretion exhibited proteolytic (gelatinase) activity, which was partially purified on a chromatography ionic exchange mono Q2 column. Additionally, the haemorrhagic activity of Philodryas olfersii venom on chicken embryos, mouse skin and peritoneum was demonstrated. Neurotoxic symptoms were demonstrated in mice inoculated with Philodryas olfersii venom. In conclusion, Philodryas olfersii venom showed proteolytic, haemorrhagic, and neurotoxic activities, thus increasing the interest in the high toxic action of Philodryas venom.Sociedade Brasileira de Medicina Tropical - SBMT2006-04-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822006000200012Revista da Sociedade Brasileira de Medicina Tropical v.39 n.2 2006reponame:Revista da Sociedade Brasileira de Medicina Tropicalinstname:Sociedade Brasileira de Medicina Tropical (SBMT)instacron:SBMT10.1590/S0037-86822006000200012info:eu-repo/semantics/openAccessRodríguez-Acosta,AlexisLemoine,KarelNavarrete,LuisGirón,María E.Aguilar,Irmaeng2006-05-05T00:00:00Zoai:scielo:S0037-86822006000200012Revistahttps://www.sbmt.org.br/portal/revista/ONGhttps://old.scielo.br/oai/scielo-oai.php||dalmo@rsbmt.uftm.edu.br|| rsbmt@rsbmt.uftm.edu.br1678-98490037-8682opendoar:2006-05-05T00:00Revista da Sociedade Brasileira de Medicina Tropical - Sociedade Brasileira de Medicina Tropical (SBMT)false
dc.title.none.fl_str_mv Experimental ophitoxemia produced by the opisthoglyphous lora snake (Philodryas olfersii) venom
title Experimental ophitoxemia produced by the opisthoglyphous lora snake (Philodryas olfersii) venom
spellingShingle Experimental ophitoxemia produced by the opisthoglyphous lora snake (Philodryas olfersii) venom
Rodríguez-Acosta,Alexis
Colubridae
Haemorrhage
Neurotoxic
Philodryas olfersii
Proteolytic activity
Venom
title_short Experimental ophitoxemia produced by the opisthoglyphous lora snake (Philodryas olfersii) venom
title_full Experimental ophitoxemia produced by the opisthoglyphous lora snake (Philodryas olfersii) venom
title_fullStr Experimental ophitoxemia produced by the opisthoglyphous lora snake (Philodryas olfersii) venom
title_full_unstemmed Experimental ophitoxemia produced by the opisthoglyphous lora snake (Philodryas olfersii) venom
title_sort Experimental ophitoxemia produced by the opisthoglyphous lora snake (Philodryas olfersii) venom
author Rodríguez-Acosta,Alexis
author_facet Rodríguez-Acosta,Alexis
Lemoine,Karel
Navarrete,Luis
Girón,María E.
Aguilar,Irma
author_role author
author2 Lemoine,Karel
Navarrete,Luis
Girón,María E.
Aguilar,Irma
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Rodríguez-Acosta,Alexis
Lemoine,Karel
Navarrete,Luis
Girón,María E.
Aguilar,Irma
dc.subject.por.fl_str_mv Colubridae
Haemorrhage
Neurotoxic
Philodryas olfersii
Proteolytic activity
Venom
topic Colubridae
Haemorrhage
Neurotoxic
Philodryas olfersii
Proteolytic activity
Venom
description Several colubrid snakes produce venomous oral secretions. In this work, the venom collected from Venezuelan opisthoglyphous (rear-fanged) Philodryas olfersii snake was studied. Different proteins were present in its venom and they were characterized by 20% SDS-PAGE protein electrophoresis. The secretion exhibited proteolytic (gelatinase) activity, which was partially purified on a chromatography ionic exchange mono Q2 column. Additionally, the haemorrhagic activity of Philodryas olfersii venom on chicken embryos, mouse skin and peritoneum was demonstrated. Neurotoxic symptoms were demonstrated in mice inoculated with Philodryas olfersii venom. In conclusion, Philodryas olfersii venom showed proteolytic, haemorrhagic, and neurotoxic activities, thus increasing the interest in the high toxic action of Philodryas venom.
publishDate 2006
dc.date.none.fl_str_mv 2006-04-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822006000200012
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822006000200012
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0037-86822006000200012
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Medicina Tropical - SBMT
publisher.none.fl_str_mv Sociedade Brasileira de Medicina Tropical - SBMT
dc.source.none.fl_str_mv Revista da Sociedade Brasileira de Medicina Tropical v.39 n.2 2006
reponame:Revista da Sociedade Brasileira de Medicina Tropical
instname:Sociedade Brasileira de Medicina Tropical (SBMT)
instacron:SBMT
instname_str Sociedade Brasileira de Medicina Tropical (SBMT)
instacron_str SBMT
institution SBMT
reponame_str Revista da Sociedade Brasileira de Medicina Tropical
collection Revista da Sociedade Brasileira de Medicina Tropical
repository.name.fl_str_mv Revista da Sociedade Brasileira de Medicina Tropical - Sociedade Brasileira de Medicina Tropical (SBMT)
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