Experimental ophitoxemia produced by the opisthoglyphous lora snake (Philodryas olfersii) venom
Autor(a) principal: | |
---|---|
Data de Publicação: | 2006 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Revista da Sociedade Brasileira de Medicina Tropical |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822006000200012 |
Resumo: | Several colubrid snakes produce venomous oral secretions. In this work, the venom collected from Venezuelan opisthoglyphous (rear-fanged) Philodryas olfersii snake was studied. Different proteins were present in its venom and they were characterized by 20% SDS-PAGE protein electrophoresis. The secretion exhibited proteolytic (gelatinase) activity, which was partially purified on a chromatography ionic exchange mono Q2 column. Additionally, the haemorrhagic activity of Philodryas olfersii venom on chicken embryos, mouse skin and peritoneum was demonstrated. Neurotoxic symptoms were demonstrated in mice inoculated with Philodryas olfersii venom. In conclusion, Philodryas olfersii venom showed proteolytic, haemorrhagic, and neurotoxic activities, thus increasing the interest in the high toxic action of Philodryas venom. |
id |
SBMT-1_9352d80e0433e89920f4783eb04b2642 |
---|---|
oai_identifier_str |
oai:scielo:S0037-86822006000200012 |
network_acronym_str |
SBMT-1 |
network_name_str |
Revista da Sociedade Brasileira de Medicina Tropical |
repository_id_str |
|
spelling |
Experimental ophitoxemia produced by the opisthoglyphous lora snake (Philodryas olfersii) venomColubridaeHaemorrhageNeurotoxicPhilodryas olfersiiProteolytic activityVenomSeveral colubrid snakes produce venomous oral secretions. In this work, the venom collected from Venezuelan opisthoglyphous (rear-fanged) Philodryas olfersii snake was studied. Different proteins were present in its venom and they were characterized by 20% SDS-PAGE protein electrophoresis. The secretion exhibited proteolytic (gelatinase) activity, which was partially purified on a chromatography ionic exchange mono Q2 column. Additionally, the haemorrhagic activity of Philodryas olfersii venom on chicken embryos, mouse skin and peritoneum was demonstrated. Neurotoxic symptoms were demonstrated in mice inoculated with Philodryas olfersii venom. In conclusion, Philodryas olfersii venom showed proteolytic, haemorrhagic, and neurotoxic activities, thus increasing the interest in the high toxic action of Philodryas venom.Sociedade Brasileira de Medicina Tropical - SBMT2006-04-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822006000200012Revista da Sociedade Brasileira de Medicina Tropical v.39 n.2 2006reponame:Revista da Sociedade Brasileira de Medicina Tropicalinstname:Sociedade Brasileira de Medicina Tropical (SBMT)instacron:SBMT10.1590/S0037-86822006000200012info:eu-repo/semantics/openAccessRodríguez-Acosta,AlexisLemoine,KarelNavarrete,LuisGirón,María E.Aguilar,Irmaeng2006-05-05T00:00:00Zoai:scielo:S0037-86822006000200012Revistahttps://www.sbmt.org.br/portal/revista/ONGhttps://old.scielo.br/oai/scielo-oai.php||dalmo@rsbmt.uftm.edu.br|| rsbmt@rsbmt.uftm.edu.br1678-98490037-8682opendoar:2006-05-05T00:00Revista da Sociedade Brasileira de Medicina Tropical - Sociedade Brasileira de Medicina Tropical (SBMT)false |
dc.title.none.fl_str_mv |
Experimental ophitoxemia produced by the opisthoglyphous lora snake (Philodryas olfersii) venom |
title |
Experimental ophitoxemia produced by the opisthoglyphous lora snake (Philodryas olfersii) venom |
spellingShingle |
Experimental ophitoxemia produced by the opisthoglyphous lora snake (Philodryas olfersii) venom Rodríguez-Acosta,Alexis Colubridae Haemorrhage Neurotoxic Philodryas olfersii Proteolytic activity Venom |
title_short |
Experimental ophitoxemia produced by the opisthoglyphous lora snake (Philodryas olfersii) venom |
title_full |
Experimental ophitoxemia produced by the opisthoglyphous lora snake (Philodryas olfersii) venom |
title_fullStr |
Experimental ophitoxemia produced by the opisthoglyphous lora snake (Philodryas olfersii) venom |
title_full_unstemmed |
Experimental ophitoxemia produced by the opisthoglyphous lora snake (Philodryas olfersii) venom |
title_sort |
Experimental ophitoxemia produced by the opisthoglyphous lora snake (Philodryas olfersii) venom |
author |
Rodríguez-Acosta,Alexis |
author_facet |
Rodríguez-Acosta,Alexis Lemoine,Karel Navarrete,Luis Girón,María E. Aguilar,Irma |
author_role |
author |
author2 |
Lemoine,Karel Navarrete,Luis Girón,María E. Aguilar,Irma |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Rodríguez-Acosta,Alexis Lemoine,Karel Navarrete,Luis Girón,María E. Aguilar,Irma |
dc.subject.por.fl_str_mv |
Colubridae Haemorrhage Neurotoxic Philodryas olfersii Proteolytic activity Venom |
topic |
Colubridae Haemorrhage Neurotoxic Philodryas olfersii Proteolytic activity Venom |
description |
Several colubrid snakes produce venomous oral secretions. In this work, the venom collected from Venezuelan opisthoglyphous (rear-fanged) Philodryas olfersii snake was studied. Different proteins were present in its venom and they were characterized by 20% SDS-PAGE protein electrophoresis. The secretion exhibited proteolytic (gelatinase) activity, which was partially purified on a chromatography ionic exchange mono Q2 column. Additionally, the haemorrhagic activity of Philodryas olfersii venom on chicken embryos, mouse skin and peritoneum was demonstrated. Neurotoxic symptoms were demonstrated in mice inoculated with Philodryas olfersii venom. In conclusion, Philodryas olfersii venom showed proteolytic, haemorrhagic, and neurotoxic activities, thus increasing the interest in the high toxic action of Philodryas venom. |
publishDate |
2006 |
dc.date.none.fl_str_mv |
2006-04-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822006000200012 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822006000200012 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0037-86822006000200012 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Medicina Tropical - SBMT |
publisher.none.fl_str_mv |
Sociedade Brasileira de Medicina Tropical - SBMT |
dc.source.none.fl_str_mv |
Revista da Sociedade Brasileira de Medicina Tropical v.39 n.2 2006 reponame:Revista da Sociedade Brasileira de Medicina Tropical instname:Sociedade Brasileira de Medicina Tropical (SBMT) instacron:SBMT |
instname_str |
Sociedade Brasileira de Medicina Tropical (SBMT) |
instacron_str |
SBMT |
institution |
SBMT |
reponame_str |
Revista da Sociedade Brasileira de Medicina Tropical |
collection |
Revista da Sociedade Brasileira de Medicina Tropical |
repository.name.fl_str_mv |
Revista da Sociedade Brasileira de Medicina Tropical - Sociedade Brasileira de Medicina Tropical (SBMT) |
repository.mail.fl_str_mv |
||dalmo@rsbmt.uftm.edu.br|| rsbmt@rsbmt.uftm.edu.br |
_version_ |
1752122153311928320 |