Abnormal spontaneous interleukin 8 receptor expression: a brief report of two cases

Detalhes bibliográficos
Autor(a) principal: Antas,Paulo
Data de Publicação: 2012
Outros Autores: Holland,Steven, Sterling,Timothy
Tipo de documento: Relatório
Idioma: eng
Título da fonte: Revista da Sociedade Brasileira de Medicina Tropical
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822012000100029
Resumo: Interleukin 8 (CXCL8) is an autocrine chemokine specific for the chemoattraction and activation of granulocytes, NKT cells and T lymphocytes. Patients with tuberculosis and latent Mycobacterium tuberculosis infection were assessed for the spontaneous expression of CXCR1 (CD128) and CXCR2 on lymphocytes and monocytes. Compared with ex vivo profiles, increased spontaneous CXCR2 expression and normal CXCR1 expression were found on lymphocytes in two out of 59 individuals. Monocytes showed normal ex vivo profiles for both receptors. After stimulation with purified protein derivative, the in vitro levels of CXCL8 were below the median levels of all patients with prior tuberculosis. Spontaneous CXCR2 modulation did not cause notable variation in the in vitro levels of CXCL8.
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spelling Abnormal spontaneous interleukin 8 receptor expression: a brief report of two casesInterleukin 8 receptorLymphocytesCytokinesInterleukin 8 (CXCL8) is an autocrine chemokine specific for the chemoattraction and activation of granulocytes, NKT cells and T lymphocytes. Patients with tuberculosis and latent Mycobacterium tuberculosis infection were assessed for the spontaneous expression of CXCR1 (CD128) and CXCR2 on lymphocytes and monocytes. Compared with ex vivo profiles, increased spontaneous CXCR2 expression and normal CXCR1 expression were found on lymphocytes in two out of 59 individuals. Monocytes showed normal ex vivo profiles for both receptors. After stimulation with purified protein derivative, the in vitro levels of CXCL8 were below the median levels of all patients with prior tuberculosis. Spontaneous CXCR2 modulation did not cause notable variation in the in vitro levels of CXCL8.Sociedade Brasileira de Medicina Tropical - SBMT2012-02-01info:eu-repo/semantics/reportinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822012000100029Revista da Sociedade Brasileira de Medicina Tropical v.45 n.1 2012reponame:Revista da Sociedade Brasileira de Medicina Tropicalinstname:Sociedade Brasileira de Medicina Tropical (SBMT)instacron:SBMT10.1590/S0037-86822012000100029info:eu-repo/semantics/openAccessAntas,PauloHolland,StevenSterling,Timothyeng2012-02-27T00:00:00Zoai:scielo:S0037-86822012000100029Revistahttps://www.sbmt.org.br/portal/revista/ONGhttps://old.scielo.br/oai/scielo-oai.php||dalmo@rsbmt.uftm.edu.br|| rsbmt@rsbmt.uftm.edu.br1678-98490037-8682opendoar:2012-02-27T00:00Revista da Sociedade Brasileira de Medicina Tropical - Sociedade Brasileira de Medicina Tropical (SBMT)false
dc.title.none.fl_str_mv Abnormal spontaneous interleukin 8 receptor expression: a brief report of two cases
title Abnormal spontaneous interleukin 8 receptor expression: a brief report of two cases
spellingShingle Abnormal spontaneous interleukin 8 receptor expression: a brief report of two cases
Antas,Paulo
Interleukin 8 receptor
Lymphocytes
Cytokines
title_short Abnormal spontaneous interleukin 8 receptor expression: a brief report of two cases
title_full Abnormal spontaneous interleukin 8 receptor expression: a brief report of two cases
title_fullStr Abnormal spontaneous interleukin 8 receptor expression: a brief report of two cases
title_full_unstemmed Abnormal spontaneous interleukin 8 receptor expression: a brief report of two cases
title_sort Abnormal spontaneous interleukin 8 receptor expression: a brief report of two cases
author Antas,Paulo
author_facet Antas,Paulo
Holland,Steven
Sterling,Timothy
author_role author
author2 Holland,Steven
Sterling,Timothy
author2_role author
author
dc.contributor.author.fl_str_mv Antas,Paulo
Holland,Steven
Sterling,Timothy
dc.subject.por.fl_str_mv Interleukin 8 receptor
Lymphocytes
Cytokines
topic Interleukin 8 receptor
Lymphocytes
Cytokines
description Interleukin 8 (CXCL8) is an autocrine chemokine specific for the chemoattraction and activation of granulocytes, NKT cells and T lymphocytes. Patients with tuberculosis and latent Mycobacterium tuberculosis infection were assessed for the spontaneous expression of CXCR1 (CD128) and CXCR2 on lymphocytes and monocytes. Compared with ex vivo profiles, increased spontaneous CXCR2 expression and normal CXCR1 expression were found on lymphocytes in two out of 59 individuals. Monocytes showed normal ex vivo profiles for both receptors. After stimulation with purified protein derivative, the in vitro levels of CXCL8 were below the median levels of all patients with prior tuberculosis. Spontaneous CXCR2 modulation did not cause notable variation in the in vitro levels of CXCL8.
publishDate 2012
dc.date.none.fl_str_mv 2012-02-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/report
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
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status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822012000100029
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822012000100029
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0037-86822012000100029
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Medicina Tropical - SBMT
publisher.none.fl_str_mv Sociedade Brasileira de Medicina Tropical - SBMT
dc.source.none.fl_str_mv Revista da Sociedade Brasileira de Medicina Tropical v.45 n.1 2012
reponame:Revista da Sociedade Brasileira de Medicina Tropical
instname:Sociedade Brasileira de Medicina Tropical (SBMT)
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instacron_str SBMT
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reponame_str Revista da Sociedade Brasileira de Medicina Tropical
collection Revista da Sociedade Brasileira de Medicina Tropical
repository.name.fl_str_mv Revista da Sociedade Brasileira de Medicina Tropical - Sociedade Brasileira de Medicina Tropical (SBMT)
repository.mail.fl_str_mv ||dalmo@rsbmt.uftm.edu.br|| rsbmt@rsbmt.uftm.edu.br
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