Bee sting envenomation severe cases in Manaus, Brazilian Amazon: clinical characteristics and immune markers of case reports

• Autor(a) principal: Mendonça-da-Silva,Iran
• Data de Publicação: 2021
• Outros Autores: Monteiro,Wuelton Marcelo, Sachett,Jacqueline Almeida Gonçalves, Barbosa,Endila Souza, Cordeiro-dos-Santos,Marcelo, Lacerda,Marcus Vinícius Guimarães, Melo,Gisely Cardoso, Costa,Allyson Guimarães, Val,Fernando Fonseca Almeida
• Tipo de documento: Relatório
• Idioma: eng
• Título da fonte: Revista da Sociedade Brasileira de Medicina Tropical
• Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822021000100707
• topic: Africanized bees; Inflammatory response; Systemic injury

Abstract Bee venom is a natural toxin composed of several peptides. Massive envenoming causes severe local and systemic reactions. We report two cases of severe bee envenomation, of which one was fatal. We also describe clinical characteristics and immune markers. Both victims suffered from respiratory distress, renal failure, rhabdomyolysis, and shock. They required invasive mechanical ventilation, vasoactive drugs, and renal replacement therapy. Moreover, serum levels of chemokines, cytokines, and cell-free circulating nucleic acids demonstrated an intense inflammatory process. Massive envenoming produced systemic injury in the victims, with an uncontrolled inflammatory response, and a more significant chemotactic response in the fatal case.