HTLV-I associated myelopathy in the northern region of Brazil (Belém-Pará): serological and clinical features of three cases
Autor(a) principal: | |
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Data de Publicação: | 2002 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Revista da Sociedade Brasileira de Medicina Tropical |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822002000300008 |
Resumo: | Three patients (males, black, ages 37, 40 and 57) attended a university clinic with a progressive paraparesis of obscure origin. One patient who referred disease duration of more than 16 years, showed diminished deep reflexes, bilateral Babinski's sign, diminished sensation of vibration, abnormal bladder function and back pain. The other two patients (with one and six years of disease duration) complained of weakness in one leg, increased deep reflexes and back pain. Babinski's sign and bladder disturbance were also present in the patient with six years of disease. Blood samples tested by an enzyme immune assay and a discriminatory Western blot were positive for HTLV-I. The familial analysis of one patient showed a possible pattern of sexual and vertical transmission of the virus. To the best of our knowledge, these are the first cases of a proven association between HTLV-I and TSP/HAM in Belem, Para, and emphasize the need to actively look for cases of neurological disease associated to the virus. |
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HTLV-I associated myelopathy in the northern region of Brazil (Belém-Pará): serological and clinical features of three casesHTLV-IMyelopathyTSP/HAMNeurological diseaseThree patients (males, black, ages 37, 40 and 57) attended a university clinic with a progressive paraparesis of obscure origin. One patient who referred disease duration of more than 16 years, showed diminished deep reflexes, bilateral Babinski's sign, diminished sensation of vibration, abnormal bladder function and back pain. The other two patients (with one and six years of disease duration) complained of weakness in one leg, increased deep reflexes and back pain. Babinski's sign and bladder disturbance were also present in the patient with six years of disease. Blood samples tested by an enzyme immune assay and a discriminatory Western blot were positive for HTLV-I. The familial analysis of one patient showed a possible pattern of sexual and vertical transmission of the virus. To the best of our knowledge, these are the first cases of a proven association between HTLV-I and TSP/HAM in Belem, Para, and emphasize the need to actively look for cases of neurological disease associated to the virus.Sociedade Brasileira de Medicina Tropical - SBMT2002-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822002000300008Revista da Sociedade Brasileira de Medicina Tropical v.35 n.3 2002reponame:Revista da Sociedade Brasileira de Medicina Tropicalinstname:Sociedade Brasileira de Medicina Tropical (SBMT)instacron:SBMT10.1590/S0037-86822002000300008info:eu-repo/semantics/openAccessIshak,RicardoCavalcante,FernandoVallinoto,Antonio Carlos R.Azevedo,Vânia NakauthIshak,Marluísa O. Guimarãeseng2002-05-24T00:00:00Zoai:scielo:S0037-86822002000300008Revistahttps://www.sbmt.org.br/portal/revista/ONGhttps://old.scielo.br/oai/scielo-oai.php||dalmo@rsbmt.uftm.edu.br|| rsbmt@rsbmt.uftm.edu.br1678-98490037-8682opendoar:2002-05-24T00:00Revista da Sociedade Brasileira de Medicina Tropical - Sociedade Brasileira de Medicina Tropical (SBMT)false |
dc.title.none.fl_str_mv |
HTLV-I associated myelopathy in the northern region of Brazil (Belém-Pará): serological and clinical features of three cases |
title |
HTLV-I associated myelopathy in the northern region of Brazil (Belém-Pará): serological and clinical features of three cases |
spellingShingle |
HTLV-I associated myelopathy in the northern region of Brazil (Belém-Pará): serological and clinical features of three cases Ishak,Ricardo HTLV-I Myelopathy TSP/HAM Neurological disease |
title_short |
HTLV-I associated myelopathy in the northern region of Brazil (Belém-Pará): serological and clinical features of three cases |
title_full |
HTLV-I associated myelopathy in the northern region of Brazil (Belém-Pará): serological and clinical features of three cases |
title_fullStr |
HTLV-I associated myelopathy in the northern region of Brazil (Belém-Pará): serological and clinical features of three cases |
title_full_unstemmed |
HTLV-I associated myelopathy in the northern region of Brazil (Belém-Pará): serological and clinical features of three cases |
title_sort |
HTLV-I associated myelopathy in the northern region of Brazil (Belém-Pará): serological and clinical features of three cases |
author |
Ishak,Ricardo |
author_facet |
Ishak,Ricardo Cavalcante,Fernando Vallinoto,Antonio Carlos R. Azevedo,Vânia Nakauth Ishak,Marluísa O. Guimarães |
author_role |
author |
author2 |
Cavalcante,Fernando Vallinoto,Antonio Carlos R. Azevedo,Vânia Nakauth Ishak,Marluísa O. Guimarães |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Ishak,Ricardo Cavalcante,Fernando Vallinoto,Antonio Carlos R. Azevedo,Vânia Nakauth Ishak,Marluísa O. Guimarães |
dc.subject.por.fl_str_mv |
HTLV-I Myelopathy TSP/HAM Neurological disease |
topic |
HTLV-I Myelopathy TSP/HAM Neurological disease |
description |
Three patients (males, black, ages 37, 40 and 57) attended a university clinic with a progressive paraparesis of obscure origin. One patient who referred disease duration of more than 16 years, showed diminished deep reflexes, bilateral Babinski's sign, diminished sensation of vibration, abnormal bladder function and back pain. The other two patients (with one and six years of disease duration) complained of weakness in one leg, increased deep reflexes and back pain. Babinski's sign and bladder disturbance were also present in the patient with six years of disease. Blood samples tested by an enzyme immune assay and a discriminatory Western blot were positive for HTLV-I. The familial analysis of one patient showed a possible pattern of sexual and vertical transmission of the virus. To the best of our knowledge, these are the first cases of a proven association between HTLV-I and TSP/HAM in Belem, Para, and emphasize the need to actively look for cases of neurological disease associated to the virus. |
publishDate |
2002 |
dc.date.none.fl_str_mv |
2002-06-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822002000300008 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822002000300008 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0037-86822002000300008 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Medicina Tropical - SBMT |
publisher.none.fl_str_mv |
Sociedade Brasileira de Medicina Tropical - SBMT |
dc.source.none.fl_str_mv |
Revista da Sociedade Brasileira de Medicina Tropical v.35 n.3 2002 reponame:Revista da Sociedade Brasileira de Medicina Tropical instname:Sociedade Brasileira de Medicina Tropical (SBMT) instacron:SBMT |
instname_str |
Sociedade Brasileira de Medicina Tropical (SBMT) |
instacron_str |
SBMT |
institution |
SBMT |
reponame_str |
Revista da Sociedade Brasileira de Medicina Tropical |
collection |
Revista da Sociedade Brasileira de Medicina Tropical |
repository.name.fl_str_mv |
Revista da Sociedade Brasileira de Medicina Tropical - Sociedade Brasileira de Medicina Tropical (SBMT) |
repository.mail.fl_str_mv |
||dalmo@rsbmt.uftm.edu.br|| rsbmt@rsbmt.uftm.edu.br |
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1752122151606943744 |