Glucantime resistant Leishmania promastigotes are sensitive to pentostam

Detalhes bibliográficos
Autor(a) principal: Moreira,Elizabeth Spangler Andrade
Data de Publicação: 1992
Outros Autores: Guerra,Juliana Becattini, Petrillo-Peixoto,Maria de Lourdes
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Revista da Sociedade Brasileira de Medicina Tropical
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86821992000400006
Resumo: Growth inhibition in vitro tests were used to study the susceptibility to pentostam of different Leishmania strains involved in cutaneous and mucocutaneos leishmaniasis - one glucantime sensitive strain, three naturally glucantime resistant strains and one glucantime resistant line developed by in vitro drug exposure. Contrasting with the high degree , of glucantime resistance, all strains were sensitive to pentostam. These differences suggest that there is some relationship between chemical structure and in vitro activity for these antimonial compounds. These data justify a clinical re-evaluation to compare therapeutic efficacy of glucantime and pentostam in the treatment of leishmaniasis.
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spelling Glucantime resistant Leishmania promastigotes are sensitive to pentostamLeishmania Pentavalent antimonial compoundsGrowth inhibitionExperimental chemotherapyGrowth inhibition in vitro tests were used to study the susceptibility to pentostam of different Leishmania strains involved in cutaneous and mucocutaneos leishmaniasis - one glucantime sensitive strain, three naturally glucantime resistant strains and one glucantime resistant line developed by in vitro drug exposure. Contrasting with the high degree , of glucantime resistance, all strains were sensitive to pentostam. These differences suggest that there is some relationship between chemical structure and in vitro activity for these antimonial compounds. These data justify a clinical re-evaluation to compare therapeutic efficacy of glucantime and pentostam in the treatment of leishmaniasis.Sociedade Brasileira de Medicina Tropical - SBMT1992-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86821992000400006Revista da Sociedade Brasileira de Medicina Tropical v.25 n.4 1992reponame:Revista da Sociedade Brasileira de Medicina Tropicalinstname:Sociedade Brasileira de Medicina Tropical (SBMT)instacron:SBMT10.1590/S0037-86821992000400006info:eu-repo/semantics/openAccessMoreira,Elizabeth Spangler AndradeGuerra,Juliana BecattiniPetrillo-Peixoto,Maria de Lourdeseng2013-04-19T00:00:00Zoai:scielo:S0037-86821992000400006Revistahttps://www.sbmt.org.br/portal/revista/ONGhttps://old.scielo.br/oai/scielo-oai.php||dalmo@rsbmt.uftm.edu.br|| rsbmt@rsbmt.uftm.edu.br1678-98490037-8682opendoar:2013-04-19T00:00Revista da Sociedade Brasileira de Medicina Tropical - Sociedade Brasileira de Medicina Tropical (SBMT)false
dc.title.none.fl_str_mv Glucantime resistant Leishmania promastigotes are sensitive to pentostam
title Glucantime resistant Leishmania promastigotes are sensitive to pentostam
spellingShingle Glucantime resistant Leishmania promastigotes are sensitive to pentostam
Moreira,Elizabeth Spangler Andrade
Leishmania Pentavalent antimonial compounds
Growth inhibition
Experimental chemotherapy
title_short Glucantime resistant Leishmania promastigotes are sensitive to pentostam
title_full Glucantime resistant Leishmania promastigotes are sensitive to pentostam
title_fullStr Glucantime resistant Leishmania promastigotes are sensitive to pentostam
title_full_unstemmed Glucantime resistant Leishmania promastigotes are sensitive to pentostam
title_sort Glucantime resistant Leishmania promastigotes are sensitive to pentostam
author Moreira,Elizabeth Spangler Andrade
author_facet Moreira,Elizabeth Spangler Andrade
Guerra,Juliana Becattini
Petrillo-Peixoto,Maria de Lourdes
author_role author
author2 Guerra,Juliana Becattini
Petrillo-Peixoto,Maria de Lourdes
author2_role author
author
dc.contributor.author.fl_str_mv Moreira,Elizabeth Spangler Andrade
Guerra,Juliana Becattini
Petrillo-Peixoto,Maria de Lourdes
dc.subject.por.fl_str_mv Leishmania Pentavalent antimonial compounds
Growth inhibition
Experimental chemotherapy
topic Leishmania Pentavalent antimonial compounds
Growth inhibition
Experimental chemotherapy
description Growth inhibition in vitro tests were used to study the susceptibility to pentostam of different Leishmania strains involved in cutaneous and mucocutaneos leishmaniasis - one glucantime sensitive strain, three naturally glucantime resistant strains and one glucantime resistant line developed by in vitro drug exposure. Contrasting with the high degree , of glucantime resistance, all strains were sensitive to pentostam. These differences suggest that there is some relationship between chemical structure and in vitro activity for these antimonial compounds. These data justify a clinical re-evaluation to compare therapeutic efficacy of glucantime and pentostam in the treatment of leishmaniasis.
publishDate 1992
dc.date.none.fl_str_mv 1992-12-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
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status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86821992000400006
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86821992000400006
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0037-86821992000400006
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Medicina Tropical - SBMT
publisher.none.fl_str_mv Sociedade Brasileira de Medicina Tropical - SBMT
dc.source.none.fl_str_mv Revista da Sociedade Brasileira de Medicina Tropical v.25 n.4 1992
reponame:Revista da Sociedade Brasileira de Medicina Tropical
instname:Sociedade Brasileira de Medicina Tropical (SBMT)
instacron:SBMT
instname_str Sociedade Brasileira de Medicina Tropical (SBMT)
instacron_str SBMT
institution SBMT
reponame_str Revista da Sociedade Brasileira de Medicina Tropical
collection Revista da Sociedade Brasileira de Medicina Tropical
repository.name.fl_str_mv Revista da Sociedade Brasileira de Medicina Tropical - Sociedade Brasileira de Medicina Tropical (SBMT)
repository.mail.fl_str_mv ||dalmo@rsbmt.uftm.edu.br|| rsbmt@rsbmt.uftm.edu.br
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