Glucantime resistant Leishmania promastigotes are sensitive to pentostam
Autor(a) principal: | |
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Data de Publicação: | 1992 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Revista da Sociedade Brasileira de Medicina Tropical |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86821992000400006 |
Resumo: | Growth inhibition in vitro tests were used to study the susceptibility to pentostam of different Leishmania strains involved in cutaneous and mucocutaneos leishmaniasis - one glucantime sensitive strain, three naturally glucantime resistant strains and one glucantime resistant line developed by in vitro drug exposure. Contrasting with the high degree , of glucantime resistance, all strains were sensitive to pentostam. These differences suggest that there is some relationship between chemical structure and in vitro activity for these antimonial compounds. These data justify a clinical re-evaluation to compare therapeutic efficacy of glucantime and pentostam in the treatment of leishmaniasis. |
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Glucantime resistant Leishmania promastigotes are sensitive to pentostamLeishmania Pentavalent antimonial compoundsGrowth inhibitionExperimental chemotherapyGrowth inhibition in vitro tests were used to study the susceptibility to pentostam of different Leishmania strains involved in cutaneous and mucocutaneos leishmaniasis - one glucantime sensitive strain, three naturally glucantime resistant strains and one glucantime resistant line developed by in vitro drug exposure. Contrasting with the high degree , of glucantime resistance, all strains were sensitive to pentostam. These differences suggest that there is some relationship between chemical structure and in vitro activity for these antimonial compounds. These data justify a clinical re-evaluation to compare therapeutic efficacy of glucantime and pentostam in the treatment of leishmaniasis.Sociedade Brasileira de Medicina Tropical - SBMT1992-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86821992000400006Revista da Sociedade Brasileira de Medicina Tropical v.25 n.4 1992reponame:Revista da Sociedade Brasileira de Medicina Tropicalinstname:Sociedade Brasileira de Medicina Tropical (SBMT)instacron:SBMT10.1590/S0037-86821992000400006info:eu-repo/semantics/openAccessMoreira,Elizabeth Spangler AndradeGuerra,Juliana BecattiniPetrillo-Peixoto,Maria de Lourdeseng2013-04-19T00:00:00Zoai:scielo:S0037-86821992000400006Revistahttps://www.sbmt.org.br/portal/revista/ONGhttps://old.scielo.br/oai/scielo-oai.php||dalmo@rsbmt.uftm.edu.br|| rsbmt@rsbmt.uftm.edu.br1678-98490037-8682opendoar:2013-04-19T00:00Revista da Sociedade Brasileira de Medicina Tropical - Sociedade Brasileira de Medicina Tropical (SBMT)false |
dc.title.none.fl_str_mv |
Glucantime resistant Leishmania promastigotes are sensitive to pentostam |
title |
Glucantime resistant Leishmania promastigotes are sensitive to pentostam |
spellingShingle |
Glucantime resistant Leishmania promastigotes are sensitive to pentostam Moreira,Elizabeth Spangler Andrade Leishmania Pentavalent antimonial compounds Growth inhibition Experimental chemotherapy |
title_short |
Glucantime resistant Leishmania promastigotes are sensitive to pentostam |
title_full |
Glucantime resistant Leishmania promastigotes are sensitive to pentostam |
title_fullStr |
Glucantime resistant Leishmania promastigotes are sensitive to pentostam |
title_full_unstemmed |
Glucantime resistant Leishmania promastigotes are sensitive to pentostam |
title_sort |
Glucantime resistant Leishmania promastigotes are sensitive to pentostam |
author |
Moreira,Elizabeth Spangler Andrade |
author_facet |
Moreira,Elizabeth Spangler Andrade Guerra,Juliana Becattini Petrillo-Peixoto,Maria de Lourdes |
author_role |
author |
author2 |
Guerra,Juliana Becattini Petrillo-Peixoto,Maria de Lourdes |
author2_role |
author author |
dc.contributor.author.fl_str_mv |
Moreira,Elizabeth Spangler Andrade Guerra,Juliana Becattini Petrillo-Peixoto,Maria de Lourdes |
dc.subject.por.fl_str_mv |
Leishmania Pentavalent antimonial compounds Growth inhibition Experimental chemotherapy |
topic |
Leishmania Pentavalent antimonial compounds Growth inhibition Experimental chemotherapy |
description |
Growth inhibition in vitro tests were used to study the susceptibility to pentostam of different Leishmania strains involved in cutaneous and mucocutaneos leishmaniasis - one glucantime sensitive strain, three naturally glucantime resistant strains and one glucantime resistant line developed by in vitro drug exposure. Contrasting with the high degree , of glucantime resistance, all strains were sensitive to pentostam. These differences suggest that there is some relationship between chemical structure and in vitro activity for these antimonial compounds. These data justify a clinical re-evaluation to compare therapeutic efficacy of glucantime and pentostam in the treatment of leishmaniasis. |
publishDate |
1992 |
dc.date.none.fl_str_mv |
1992-12-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86821992000400006 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86821992000400006 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0037-86821992000400006 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Medicina Tropical - SBMT |
publisher.none.fl_str_mv |
Sociedade Brasileira de Medicina Tropical - SBMT |
dc.source.none.fl_str_mv |
Revista da Sociedade Brasileira de Medicina Tropical v.25 n.4 1992 reponame:Revista da Sociedade Brasileira de Medicina Tropical instname:Sociedade Brasileira de Medicina Tropical (SBMT) instacron:SBMT |
instname_str |
Sociedade Brasileira de Medicina Tropical (SBMT) |
instacron_str |
SBMT |
institution |
SBMT |
reponame_str |
Revista da Sociedade Brasileira de Medicina Tropical |
collection |
Revista da Sociedade Brasileira de Medicina Tropical |
repository.name.fl_str_mv |
Revista da Sociedade Brasileira de Medicina Tropical - Sociedade Brasileira de Medicina Tropical (SBMT) |
repository.mail.fl_str_mv |
||dalmo@rsbmt.uftm.edu.br|| rsbmt@rsbmt.uftm.edu.br |
_version_ |
1752122149412274176 |