Clinical and laboratory characteristics associated with dyslipidemia and liver steatosis in chronic HBV carriers
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Publication Date: | 2014 |
Other Authors: | , , , , |
Format: | Article |
Language: | eng |
Source: | Revista da Sociedade Brasileira de Medicina Tropical |
Download full: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822014000200158 |
Summary: | Introduction Chronic hepatitis B virus (HBV) infection and liver steatosis (LS) are the most common causes of chronic liver disease, and their coexistence is frequently observed in clinical practice. Although metabolic syndrome is the main cause of LS, it has not been associated with HBV infection. The aims of this study were to describe the lipid profile and prevalence of LS among HBV carriers and to identify the characteristics associated with LS in this group. Methods This retrospective cross-sectional study included hepatitis B surface antigen (HBsAg)-positive patients evaluated during 2011 and 2012. Results Of the 83 patients included, the mean age was 46.4±12.5 years, 53% were men, and 9.1% were hepatitis B e antigen (HBeAg) -positive. These patients exhibited the following lipid profile: total cholesterol = 175.4±38.8mg/dL, low-density lipoprotein (LDL) = 113.0±32.7mg/dL, and triglycerides = 91.1±45.2mg/dL. Their fasting glucose was 95.3±14.5g/dL, and fasting insulin was 6.1±5.9µIU/mL. Liver steatosis was observed on abdominal ultrasound in 11.3% of individuals. Factors associated with the presence of LS included higher levels of total cholesterol, prothrombin activity, fasting insulin, and body mass index (BMI) as well as lower levels of aspartate aminotransferase (AST). Conclusions These findings suggest that LS in patients with chronic HBV appears to be a consequence of metabolic alterations and insulin action rather than of viral factors. |
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Clinical and laboratory characteristics associated with dyslipidemia and liver steatosis in chronic HBV carriersHBVHepatitis BFatty liverLipidsCholesterolTriglycerides Introduction Chronic hepatitis B virus (HBV) infection and liver steatosis (LS) are the most common causes of chronic liver disease, and their coexistence is frequently observed in clinical practice. Although metabolic syndrome is the main cause of LS, it has not been associated with HBV infection. The aims of this study were to describe the lipid profile and prevalence of LS among HBV carriers and to identify the characteristics associated with LS in this group. Methods This retrospective cross-sectional study included hepatitis B surface antigen (HBsAg)-positive patients evaluated during 2011 and 2012. Results Of the 83 patients included, the mean age was 46.4±12.5 years, 53% were men, and 9.1% were hepatitis B e antigen (HBeAg) -positive. These patients exhibited the following lipid profile: total cholesterol = 175.4±38.8mg/dL, low-density lipoprotein (LDL) = 113.0±32.7mg/dL, and triglycerides = 91.1±45.2mg/dL. Their fasting glucose was 95.3±14.5g/dL, and fasting insulin was 6.1±5.9µIU/mL. Liver steatosis was observed on abdominal ultrasound in 11.3% of individuals. Factors associated with the presence of LS included higher levels of total cholesterol, prothrombin activity, fasting insulin, and body mass index (BMI) as well as lower levels of aspartate aminotransferase (AST). Conclusions These findings suggest that LS in patients with chronic HBV appears to be a consequence of metabolic alterations and insulin action rather than of viral factors. Sociedade Brasileira de Medicina Tropical - SBMT2014-04-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822014000200158Revista da Sociedade Brasileira de Medicina Tropical v.47 n.2 2014reponame:Revista da Sociedade Brasileira de Medicina Tropicalinstname:Sociedade Brasileira de Medicina Tropical (SBMT)instacron:SBMT10.1590/0037-8682-0009-2014info:eu-repo/semantics/openAccessNau,Angélica LucianaSoares,Júlia CristinaShiozawa,Maria Beatriz CaceseDantas-Corrêa,Esther BuzagloSchiavon,Leonardo de LuccaNarciso-Schiavon,Janaína Luzeng2014-05-15T00:00:00Zoai:scielo:S0037-86822014000200158Revistahttps://www.sbmt.org.br/portal/revista/ONGhttps://old.scielo.br/oai/scielo-oai.php||dalmo@rsbmt.uftm.edu.br|| rsbmt@rsbmt.uftm.edu.br1678-98490037-8682opendoar:2014-05-15T00:00Revista da Sociedade Brasileira de Medicina Tropical - Sociedade Brasileira de Medicina Tropical (SBMT)false |
dc.title.none.fl_str_mv |
Clinical and laboratory characteristics associated with dyslipidemia and liver steatosis in chronic HBV carriers |
title |
Clinical and laboratory characteristics associated with dyslipidemia and liver steatosis in chronic HBV carriers |
spellingShingle |
Clinical and laboratory characteristics associated with dyslipidemia and liver steatosis in chronic HBV carriers Nau,Angélica Luciana HBV Hepatitis B Fatty liver Lipids Cholesterol Triglycerides |
title_short |
Clinical and laboratory characteristics associated with dyslipidemia and liver steatosis in chronic HBV carriers |
title_full |
Clinical and laboratory characteristics associated with dyslipidemia and liver steatosis in chronic HBV carriers |
title_fullStr |
Clinical and laboratory characteristics associated with dyslipidemia and liver steatosis in chronic HBV carriers |
title_full_unstemmed |
Clinical and laboratory characteristics associated with dyslipidemia and liver steatosis in chronic HBV carriers |
title_sort |
Clinical and laboratory characteristics associated with dyslipidemia and liver steatosis in chronic HBV carriers |
author |
Nau,Angélica Luciana |
author_facet |
Nau,Angélica Luciana Soares,Júlia Cristina Shiozawa,Maria Beatriz Cacese Dantas-Corrêa,Esther Buzaglo Schiavon,Leonardo de Lucca Narciso-Schiavon,Janaína Luz |
author_role |
author |
author2 |
Soares,Júlia Cristina Shiozawa,Maria Beatriz Cacese Dantas-Corrêa,Esther Buzaglo Schiavon,Leonardo de Lucca Narciso-Schiavon,Janaína Luz |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Nau,Angélica Luciana Soares,Júlia Cristina Shiozawa,Maria Beatriz Cacese Dantas-Corrêa,Esther Buzaglo Schiavon,Leonardo de Lucca Narciso-Schiavon,Janaína Luz |
dc.subject.por.fl_str_mv |
HBV Hepatitis B Fatty liver Lipids Cholesterol Triglycerides |
topic |
HBV Hepatitis B Fatty liver Lipids Cholesterol Triglycerides |
description |
Introduction Chronic hepatitis B virus (HBV) infection and liver steatosis (LS) are the most common causes of chronic liver disease, and their coexistence is frequently observed in clinical practice. Although metabolic syndrome is the main cause of LS, it has not been associated with HBV infection. The aims of this study were to describe the lipid profile and prevalence of LS among HBV carriers and to identify the characteristics associated with LS in this group. Methods This retrospective cross-sectional study included hepatitis B surface antigen (HBsAg)-positive patients evaluated during 2011 and 2012. Results Of the 83 patients included, the mean age was 46.4±12.5 years, 53% were men, and 9.1% were hepatitis B e antigen (HBeAg) -positive. These patients exhibited the following lipid profile: total cholesterol = 175.4±38.8mg/dL, low-density lipoprotein (LDL) = 113.0±32.7mg/dL, and triglycerides = 91.1±45.2mg/dL. Their fasting glucose was 95.3±14.5g/dL, and fasting insulin was 6.1±5.9µIU/mL. Liver steatosis was observed on abdominal ultrasound in 11.3% of individuals. Factors associated with the presence of LS included higher levels of total cholesterol, prothrombin activity, fasting insulin, and body mass index (BMI) as well as lower levels of aspartate aminotransferase (AST). Conclusions These findings suggest that LS in patients with chronic HBV appears to be a consequence of metabolic alterations and insulin action rather than of viral factors. |
publishDate |
2014 |
dc.date.none.fl_str_mv |
2014-04-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822014000200158 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822014000200158 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/0037-8682-0009-2014 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Medicina Tropical - SBMT |
publisher.none.fl_str_mv |
Sociedade Brasileira de Medicina Tropical - SBMT |
dc.source.none.fl_str_mv |
Revista da Sociedade Brasileira de Medicina Tropical v.47 n.2 2014 reponame:Revista da Sociedade Brasileira de Medicina Tropical instname:Sociedade Brasileira de Medicina Tropical (SBMT) instacron:SBMT |
instname_str |
Sociedade Brasileira de Medicina Tropical (SBMT) |
instacron_str |
SBMT |
institution |
SBMT |
reponame_str |
Revista da Sociedade Brasileira de Medicina Tropical |
collection |
Revista da Sociedade Brasileira de Medicina Tropical |
repository.name.fl_str_mv |
Revista da Sociedade Brasileira de Medicina Tropical - Sociedade Brasileira de Medicina Tropical (SBMT) |
repository.mail.fl_str_mv |
||dalmo@rsbmt.uftm.edu.br|| rsbmt@rsbmt.uftm.edu.br |
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1752122159190245376 |