Rate of action of schistosomicides in mice infected with Schistosoma mansoni

Detalhes bibliográficos
Autor(a) principal: Katz,Naftale
Data de Publicação: 1989
Outros Autores: Dias,Emmanuel Pinto, Souza,Cecilia Pereira de, Bruce,John I., Coles,Gerald C.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Revista da Sociedade Brasileira de Medicina Tropical
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86821989000400004
Resumo: Mice infected with adult Schistosoma mansoni were dosed with a single oral dose of 125 or 250 mg/kg oltipraz, 50 or 100 mg/kg oxamniquine, or 200 or 400 mg/kg praziquantel. The mortality rate of worms and oogram changes were determined between 1 and 16 weeks after dosing. The time required between dosing and postmortem to obtain maximum effectiveness was 1 week for praziquantel, 2 weeks for oxamniquine and 8 weeks for oltipraz. Changes in oograms persisted throughout most of the experiment, although relapse has been observed at the 4th week on.
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spelling Rate of action of schistosomicides in mice infected with Schistosoma mansoniSchistosoma mansoniSchistosomicidesWorm mortalityMice infected with adult Schistosoma mansoni were dosed with a single oral dose of 125 or 250 mg/kg oltipraz, 50 or 100 mg/kg oxamniquine, or 200 or 400 mg/kg praziquantel. The mortality rate of worms and oogram changes were determined between 1 and 16 weeks after dosing. The time required between dosing and postmortem to obtain maximum effectiveness was 1 week for praziquantel, 2 weeks for oxamniquine and 8 weeks for oltipraz. Changes in oograms persisted throughout most of the experiment, although relapse has been observed at the 4th week on.Sociedade Brasileira de Medicina Tropical - SBMT1989-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86821989000400004Revista da Sociedade Brasileira de Medicina Tropical v.22 n.4 1989reponame:Revista da Sociedade Brasileira de Medicina Tropicalinstname:Sociedade Brasileira de Medicina Tropical (SBMT)instacron:SBMT10.1590/S0037-86821989000400004info:eu-repo/semantics/openAccessKatz,NaftaleDias,Emmanuel PintoSouza,Cecilia Pereira deBruce,John I.Coles,Gerald C.eng2013-05-28T00:00:00Zoai:scielo:S0037-86821989000400004Revistahttps://www.sbmt.org.br/portal/revista/ONGhttps://old.scielo.br/oai/scielo-oai.php||dalmo@rsbmt.uftm.edu.br|| rsbmt@rsbmt.uftm.edu.br1678-98490037-8682opendoar:2013-05-28T00:00Revista da Sociedade Brasileira de Medicina Tropical - Sociedade Brasileira de Medicina Tropical (SBMT)false
dc.title.none.fl_str_mv Rate of action of schistosomicides in mice infected with Schistosoma mansoni
title Rate of action of schistosomicides in mice infected with Schistosoma mansoni
spellingShingle Rate of action of schistosomicides in mice infected with Schistosoma mansoni
Katz,Naftale
Schistosoma mansoni
Schistosomicides
Worm mortality
title_short Rate of action of schistosomicides in mice infected with Schistosoma mansoni
title_full Rate of action of schistosomicides in mice infected with Schistosoma mansoni
title_fullStr Rate of action of schistosomicides in mice infected with Schistosoma mansoni
title_full_unstemmed Rate of action of schistosomicides in mice infected with Schistosoma mansoni
title_sort Rate of action of schistosomicides in mice infected with Schistosoma mansoni
author Katz,Naftale
author_facet Katz,Naftale
Dias,Emmanuel Pinto
Souza,Cecilia Pereira de
Bruce,John I.
Coles,Gerald C.
author_role author
author2 Dias,Emmanuel Pinto
Souza,Cecilia Pereira de
Bruce,John I.
Coles,Gerald C.
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Katz,Naftale
Dias,Emmanuel Pinto
Souza,Cecilia Pereira de
Bruce,John I.
Coles,Gerald C.
dc.subject.por.fl_str_mv Schistosoma mansoni
Schistosomicides
Worm mortality
topic Schistosoma mansoni
Schistosomicides
Worm mortality
description Mice infected with adult Schistosoma mansoni were dosed with a single oral dose of 125 or 250 mg/kg oltipraz, 50 or 100 mg/kg oxamniquine, or 200 or 400 mg/kg praziquantel. The mortality rate of worms and oogram changes were determined between 1 and 16 weeks after dosing. The time required between dosing and postmortem to obtain maximum effectiveness was 1 week for praziquantel, 2 weeks for oxamniquine and 8 weeks for oltipraz. Changes in oograms persisted throughout most of the experiment, although relapse has been observed at the 4th week on.
publishDate 1989
dc.date.none.fl_str_mv 1989-12-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86821989000400004
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86821989000400004
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0037-86821989000400004
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Medicina Tropical - SBMT
publisher.none.fl_str_mv Sociedade Brasileira de Medicina Tropical - SBMT
dc.source.none.fl_str_mv Revista da Sociedade Brasileira de Medicina Tropical v.22 n.4 1989
reponame:Revista da Sociedade Brasileira de Medicina Tropical
instname:Sociedade Brasileira de Medicina Tropical (SBMT)
instacron:SBMT
instname_str Sociedade Brasileira de Medicina Tropical (SBMT)
instacron_str SBMT
institution SBMT
reponame_str Revista da Sociedade Brasileira de Medicina Tropical
collection Revista da Sociedade Brasileira de Medicina Tropical
repository.name.fl_str_mv Revista da Sociedade Brasileira de Medicina Tropical - Sociedade Brasileira de Medicina Tropical (SBMT)
repository.mail.fl_str_mv ||dalmo@rsbmt.uftm.edu.br|| rsbmt@rsbmt.uftm.edu.br
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