Mesenchymal Stromal/Stem cells: Historical perspective and ongoing challenges

Detalhes bibliográficos
Autor(a) principal: Rossi, Maria Isabel Doria
Data de Publicação: 2021
Outros Autores: Bonfim, Danielle Cabral
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Brazilian Journal of Veterinary Medicine
Texto Completo: https://rbmv.org/BJVM/article/view/1120
Resumo: The potential of stem cell-based therapy was accompanied by high expectations and led, consequently, to an increase in clinical translational investments. Mesenchymal stem/stromal cells (MSCs) became the cell-based product most experimentally studied worldwide. However, uncertainties about the mechanisms and the in vivo identity of MSCs impose concerns about their large-scale use in regenerative medicine. This review comprises a historical summary on MSC, a critical discussion about their identity and function, and the ongoing challenges for their use in therapy and tissue bioengineering.
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spelling Mesenchymal Stromal/Stem cells: Historical perspective and ongoing challenges Células-tronco estromais mesenquimais: Perspectiva histórica e desafios contínuosCélulas-tronco, Células tronco mesenquimais, Células mesenquimais estromais, Terapia celularStem cells, Mesenchymal stem/stromal cells, Cell therapyThe potential of stem cell-based therapy was accompanied by high expectations and led, consequently, to an increase in clinical translational investments. Mesenchymal stem/stromal cells (MSCs) became the cell-based product most experimentally studied worldwide. However, uncertainties about the mechanisms and the in vivo identity of MSCs impose concerns about their large-scale use in regenerative medicine. This review comprises a historical summary on MSC, a critical discussion about their identity and function, and the ongoing challenges for their use in therapy and tissue bioengineering.O potencial das células-tronco adultas para terapias celulares é cercado de grande expectativa e, consequentemente, levou a um aumento nos investimentos na clínica translacional. As células-tronco mesenquimais, também denominadas células mesenquimais do estroma (MSCs, Mesenchymal Stem/Stromal Cells) se tornaram o produto celular mais estudado experimentalmente em todo o mundo. Entretanto, incertezas a respeito das propriedades e da identidade in vivo das MSCs levantam questões sobre seu uso extenso em medicina regenerativa. Esta revisão compreende um breve histórico sobre as MSCs, uma análise crítica a respeito de sua identidade e função e os permanentes desafios para seu uso terapêutico em bioengenheria.Sociedade de Medicina Veterinária do Estado do Rio de Janeiro.2021-05-13info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionRelated ArticlesArtigo de Connvidadoapplication/pdfhttps://rbmv.org/BJVM/article/view/112010.29374/2527-2179.bjvm112020Brazilian Journal of Veterinary Medicine; Vol. 42 No. 1 (2020); e112020Revista Brasileira de Medicina Veterinária; v. 42 n. 1 (2020); e1120202527-21790100-2430reponame:Brazilian Journal of Veterinary Medicineinstname:Sociedade de Medicina Veterinária do Estado do Rio de Janeiro (SOMVERJ)instacron:SBMVenghttps://rbmv.org/BJVM/article/view/1120/986Copyright (c) 2020 Maria Isabel Doria Rossi, Danielle Cabral Bonfimhttp://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessRossi, Maria Isabel Doria Bonfim, Danielle Cabral 2021-05-13T13:46:40Zoai:ojs.rbmv.org:article/1120Revistahttps://rbmv.org/BJVMONGhttps://rbmv.org/BJVM/oaicontato.rbmv@gmail.com2527-21790100-2430opendoar:2021-05-13T13:46:40Brazilian Journal of Veterinary Medicine - Sociedade de Medicina Veterinária do Estado do Rio de Janeiro (SOMVERJ)false
dc.title.none.fl_str_mv Mesenchymal Stromal/Stem cells: Historical perspective and ongoing challenges
Células-tronco estromais mesenquimais: Perspectiva histórica e desafios contínuos
title Mesenchymal Stromal/Stem cells: Historical perspective and ongoing challenges
spellingShingle Mesenchymal Stromal/Stem cells: Historical perspective and ongoing challenges
Rossi, Maria Isabel Doria
Células-tronco, Células tronco mesenquimais, Células mesenquimais estromais, Terapia celular
Stem cells, Mesenchymal stem/stromal cells, Cell therapy
title_short Mesenchymal Stromal/Stem cells: Historical perspective and ongoing challenges
title_full Mesenchymal Stromal/Stem cells: Historical perspective and ongoing challenges
title_fullStr Mesenchymal Stromal/Stem cells: Historical perspective and ongoing challenges
title_full_unstemmed Mesenchymal Stromal/Stem cells: Historical perspective and ongoing challenges
title_sort Mesenchymal Stromal/Stem cells: Historical perspective and ongoing challenges
author Rossi, Maria Isabel Doria
author_facet Rossi, Maria Isabel Doria
Bonfim, Danielle Cabral
author_role author
author2 Bonfim, Danielle Cabral
author2_role author
dc.contributor.author.fl_str_mv Rossi, Maria Isabel Doria
Bonfim, Danielle Cabral
dc.subject.por.fl_str_mv Células-tronco, Células tronco mesenquimais, Células mesenquimais estromais, Terapia celular
Stem cells, Mesenchymal stem/stromal cells, Cell therapy
topic Células-tronco, Células tronco mesenquimais, Células mesenquimais estromais, Terapia celular
Stem cells, Mesenchymal stem/stromal cells, Cell therapy
description The potential of stem cell-based therapy was accompanied by high expectations and led, consequently, to an increase in clinical translational investments. Mesenchymal stem/stromal cells (MSCs) became the cell-based product most experimentally studied worldwide. However, uncertainties about the mechanisms and the in vivo identity of MSCs impose concerns about their large-scale use in regenerative medicine. This review comprises a historical summary on MSC, a critical discussion about their identity and function, and the ongoing challenges for their use in therapy and tissue bioengineering.
publishDate 2021
dc.date.none.fl_str_mv 2021-05-13
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Related Articles
Artigo de Connvidado
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://rbmv.org/BJVM/article/view/1120
10.29374/2527-2179.bjvm112020
url https://rbmv.org/BJVM/article/view/1120
identifier_str_mv 10.29374/2527-2179.bjvm112020
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://rbmv.org/BJVM/article/view/1120/986
dc.rights.driver.fl_str_mv Copyright (c) 2020 Maria Isabel Doria Rossi, Danielle Cabral Bonfim
http://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2020 Maria Isabel Doria Rossi, Danielle Cabral Bonfim
http://creativecommons.org/licenses/by/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Sociedade de Medicina Veterinária do Estado do Rio de Janeiro.
publisher.none.fl_str_mv Sociedade de Medicina Veterinária do Estado do Rio de Janeiro.
dc.source.none.fl_str_mv Brazilian Journal of Veterinary Medicine; Vol. 42 No. 1 (2020); e112020
Revista Brasileira de Medicina Veterinária; v. 42 n. 1 (2020); e112020
2527-2179
0100-2430
reponame:Brazilian Journal of Veterinary Medicine
instname:Sociedade de Medicina Veterinária do Estado do Rio de Janeiro (SOMVERJ)
instacron:SBMV
instname_str Sociedade de Medicina Veterinária do Estado do Rio de Janeiro (SOMVERJ)
instacron_str SBMV
institution SBMV
reponame_str Brazilian Journal of Veterinary Medicine
collection Brazilian Journal of Veterinary Medicine
repository.name.fl_str_mv Brazilian Journal of Veterinary Medicine - Sociedade de Medicina Veterinária do Estado do Rio de Janeiro (SOMVERJ)
repository.mail.fl_str_mv contato.rbmv@gmail.com
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