Diabetes mellitus and hyperkalemic renal tubular acidosis: case reports and literature review

Detalhes bibliográficos
Autor(a) principal: Bello,Carlos Henrique Pires Ratto Tavares
Data de Publicação: 2017
Outros Autores: Duarte,João Sequeira, Vasconcelos,Carlos
Tipo de documento: Relatório
Idioma: eng
Título da fonte: Jornal Brasileiro de Nefrologia
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0101-28002017000400481
Resumo: ABSTRACT Hyporeninemic hypoaldosteronism, despite being common, remains an underdiagnosed entity that is more prevalent in patients with diabetes mellitus. It presents with asymptomatic hyperkalemia along with hyperchloraemic metabolic acidosis without significant renal function impairment. The underlying pathophysiological mechanism is not fully understood, but it is postulated that either aldosterone deficiency (hyporeninemic hypoaldosteronism) and/or target organ aldosterone resistance (pseudohypoaldosteronism) may be responsible. Diagnosis is based on laboratory parameters. Treatment strategy varies according to the underlying pathophysiological mechanism and etiology and aims to normalize serum potassium. Two clínical cases are reported and the relevant literature is revisited.
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spelling Diabetes mellitus and hyperkalemic renal tubular acidosis: case reports and literature reviewacidosisacidosis, renal tubulardiabetes mellitushyperkalemiahypoaldosteronismABSTRACT Hyporeninemic hypoaldosteronism, despite being common, remains an underdiagnosed entity that is more prevalent in patients with diabetes mellitus. It presents with asymptomatic hyperkalemia along with hyperchloraemic metabolic acidosis without significant renal function impairment. The underlying pathophysiological mechanism is not fully understood, but it is postulated that either aldosterone deficiency (hyporeninemic hypoaldosteronism) and/or target organ aldosterone resistance (pseudohypoaldosteronism) may be responsible. Diagnosis is based on laboratory parameters. Treatment strategy varies according to the underlying pathophysiological mechanism and etiology and aims to normalize serum potassium. Two clínical cases are reported and the relevant literature is revisited.Sociedade Brasileira de Nefrologia2017-12-01info:eu-repo/semantics/reportinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0101-28002017000400481Brazilian Journal of Nephrology v.39 n.4 2017reponame:Jornal Brasileiro de Nefrologiainstname:Sociedade Brasileira de Nefrologia (SBN)instacron:SBN10.5935/0101-2800.20170086info:eu-repo/semantics/openAccessBello,Carlos Henrique Pires Ratto TavaresDuarte,João SequeiraVasconcelos,Carloseng2018-01-04T00:00:00Zoai:scielo:S0101-28002017000400481Revistahttp://www.bjn.org.br/ONGhttps://old.scielo.br/oai/scielo-oai.php||jbn@sbn.org.br2175-82390101-2800opendoar:2018-01-04T00:00Jornal Brasileiro de Nefrologia - Sociedade Brasileira de Nefrologia (SBN)false
dc.title.none.fl_str_mv Diabetes mellitus and hyperkalemic renal tubular acidosis: case reports and literature review
title Diabetes mellitus and hyperkalemic renal tubular acidosis: case reports and literature review
spellingShingle Diabetes mellitus and hyperkalemic renal tubular acidosis: case reports and literature review
Bello,Carlos Henrique Pires Ratto Tavares
acidosis
acidosis, renal tubular
diabetes mellitus
hyperkalemia
hypoaldosteronism
title_short Diabetes mellitus and hyperkalemic renal tubular acidosis: case reports and literature review
title_full Diabetes mellitus and hyperkalemic renal tubular acidosis: case reports and literature review
title_fullStr Diabetes mellitus and hyperkalemic renal tubular acidosis: case reports and literature review
title_full_unstemmed Diabetes mellitus and hyperkalemic renal tubular acidosis: case reports and literature review
title_sort Diabetes mellitus and hyperkalemic renal tubular acidosis: case reports and literature review
author Bello,Carlos Henrique Pires Ratto Tavares
author_facet Bello,Carlos Henrique Pires Ratto Tavares
Duarte,João Sequeira
Vasconcelos,Carlos
author_role author
author2 Duarte,João Sequeira
Vasconcelos,Carlos
author2_role author
author
dc.contributor.author.fl_str_mv Bello,Carlos Henrique Pires Ratto Tavares
Duarte,João Sequeira
Vasconcelos,Carlos
dc.subject.por.fl_str_mv acidosis
acidosis, renal tubular
diabetes mellitus
hyperkalemia
hypoaldosteronism
topic acidosis
acidosis, renal tubular
diabetes mellitus
hyperkalemia
hypoaldosteronism
description ABSTRACT Hyporeninemic hypoaldosteronism, despite being common, remains an underdiagnosed entity that is more prevalent in patients with diabetes mellitus. It presents with asymptomatic hyperkalemia along with hyperchloraemic metabolic acidosis without significant renal function impairment. The underlying pathophysiological mechanism is not fully understood, but it is postulated that either aldosterone deficiency (hyporeninemic hypoaldosteronism) and/or target organ aldosterone resistance (pseudohypoaldosteronism) may be responsible. Diagnosis is based on laboratory parameters. Treatment strategy varies according to the underlying pathophysiological mechanism and etiology and aims to normalize serum potassium. Two clínical cases are reported and the relevant literature is revisited.
publishDate 2017
dc.date.none.fl_str_mv 2017-12-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/report
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format report
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0101-28002017000400481
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0101-28002017000400481
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.5935/0101-2800.20170086
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Nefrologia
publisher.none.fl_str_mv Sociedade Brasileira de Nefrologia
dc.source.none.fl_str_mv Brazilian Journal of Nephrology v.39 n.4 2017
reponame:Jornal Brasileiro de Nefrologia
instname:Sociedade Brasileira de Nefrologia (SBN)
instacron:SBN
instname_str Sociedade Brasileira de Nefrologia (SBN)
instacron_str SBN
institution SBN
reponame_str Jornal Brasileiro de Nefrologia
collection Jornal Brasileiro de Nefrologia
repository.name.fl_str_mv Jornal Brasileiro de Nefrologia - Sociedade Brasileira de Nefrologia (SBN)
repository.mail.fl_str_mv ||jbn@sbn.org.br
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