BK polyomavirus in Kidney transplant recipients: screening, monitoring and clinical management

Detalhes bibliográficos
Autor(a) principal: Varella,Rafael Brandão
Data de Publicação: 2014
Outros Autores: Almeida,Jorge Reis, Lopes,Patrícia de Fátima, Matos,Jorge Paulo Strogoff de, Menezes,Paulo, Lugon,Jocemir Ronaldo
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Jornal Brasileiro de Nefrologia
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0101-28002014000400529
Resumo: BK polyomavirus (BKPyV) is a causal agent of nephropathy, ureteral stenosis and hemorrhagic cystitis in kidney transplant recipients, and is considered an important emerging disease in transplantation. Regular screening for BKPyV reactivation mainly during the first 2 years posttransplant, with subsequent pre-emptive reduction of immunosuppression is considered the best option to avoid disease progression, since successful clearance or reduction of viremia is achieved in the vast majority of patients within 6 months. The use of drugs with antiviral properties for patients with persistent viremia has been attempted despite unclear benefits. Clinical manifestations of BKPyV nephropathy, current strategies for diagnosis and monitoring of BKPyV infection, management of immunosuppressive regimen after detection of BKPyV reactivation and the use of antiviral drugs are discussed in this review.
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spelling BK polyomavirus in Kidney transplant recipients: screening, monitoring and clinical managementinfection controlkidney transplantationmonitoringreviewBK polyomavirus (BKPyV) is a causal agent of nephropathy, ureteral stenosis and hemorrhagic cystitis in kidney transplant recipients, and is considered an important emerging disease in transplantation. Regular screening for BKPyV reactivation mainly during the first 2 years posttransplant, with subsequent pre-emptive reduction of immunosuppression is considered the best option to avoid disease progression, since successful clearance or reduction of viremia is achieved in the vast majority of patients within 6 months. The use of drugs with antiviral properties for patients with persistent viremia has been attempted despite unclear benefits. Clinical manifestations of BKPyV nephropathy, current strategies for diagnosis and monitoring of BKPyV infection, management of immunosuppressive regimen after detection of BKPyV reactivation and the use of antiviral drugs are discussed in this review.Sociedade Brasileira de Nefrologia2014-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0101-28002014000400529Brazilian Journal of Nephrology v.36 n.4 2014reponame:Jornal Brasileiro de Nefrologiainstname:Sociedade Brasileira de Nefrologia (SBN)instacron:SBN10.5935/0101-2800.20140075info:eu-repo/semantics/openAccessVarella,Rafael BrandãoAlmeida,Jorge ReisLopes,Patrícia de FátimaMatos,Jorge Paulo Strogoff deMenezes,PauloLugon,Jocemir Ronaldoeng2015-06-17T00:00:00Zoai:scielo:S0101-28002014000400529Revistahttp://www.bjn.org.br/ONGhttps://old.scielo.br/oai/scielo-oai.php||jbn@sbn.org.br2175-82390101-2800opendoar:2015-06-17T00:00Jornal Brasileiro de Nefrologia - Sociedade Brasileira de Nefrologia (SBN)false
dc.title.none.fl_str_mv BK polyomavirus in Kidney transplant recipients: screening, monitoring and clinical management
title BK polyomavirus in Kidney transplant recipients: screening, monitoring and clinical management
spellingShingle BK polyomavirus in Kidney transplant recipients: screening, monitoring and clinical management
Varella,Rafael Brandão
infection control
kidney transplantation
monitoring
review
title_short BK polyomavirus in Kidney transplant recipients: screening, monitoring and clinical management
title_full BK polyomavirus in Kidney transplant recipients: screening, monitoring and clinical management
title_fullStr BK polyomavirus in Kidney transplant recipients: screening, monitoring and clinical management
title_full_unstemmed BK polyomavirus in Kidney transplant recipients: screening, monitoring and clinical management
title_sort BK polyomavirus in Kidney transplant recipients: screening, monitoring and clinical management
author Varella,Rafael Brandão
author_facet Varella,Rafael Brandão
Almeida,Jorge Reis
Lopes,Patrícia de Fátima
Matos,Jorge Paulo Strogoff de
Menezes,Paulo
Lugon,Jocemir Ronaldo
author_role author
author2 Almeida,Jorge Reis
Lopes,Patrícia de Fátima
Matos,Jorge Paulo Strogoff de
Menezes,Paulo
Lugon,Jocemir Ronaldo
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Varella,Rafael Brandão
Almeida,Jorge Reis
Lopes,Patrícia de Fátima
Matos,Jorge Paulo Strogoff de
Menezes,Paulo
Lugon,Jocemir Ronaldo
dc.subject.por.fl_str_mv infection control
kidney transplantation
monitoring
review
topic infection control
kidney transplantation
monitoring
review
description BK polyomavirus (BKPyV) is a causal agent of nephropathy, ureteral stenosis and hemorrhagic cystitis in kidney transplant recipients, and is considered an important emerging disease in transplantation. Regular screening for BKPyV reactivation mainly during the first 2 years posttransplant, with subsequent pre-emptive reduction of immunosuppression is considered the best option to avoid disease progression, since successful clearance or reduction of viremia is achieved in the vast majority of patients within 6 months. The use of drugs with antiviral properties for patients with persistent viremia has been attempted despite unclear benefits. Clinical manifestations of BKPyV nephropathy, current strategies for diagnosis and monitoring of BKPyV infection, management of immunosuppressive regimen after detection of BKPyV reactivation and the use of antiviral drugs are discussed in this review.
publishDate 2014
dc.date.none.fl_str_mv 2014-12-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0101-28002014000400529
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0101-28002014000400529
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.5935/0101-2800.20140075
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Nefrologia
publisher.none.fl_str_mv Sociedade Brasileira de Nefrologia
dc.source.none.fl_str_mv Brazilian Journal of Nephrology v.36 n.4 2014
reponame:Jornal Brasileiro de Nefrologia
instname:Sociedade Brasileira de Nefrologia (SBN)
instacron:SBN
instname_str Sociedade Brasileira de Nefrologia (SBN)
instacron_str SBN
institution SBN
reponame_str Jornal Brasileiro de Nefrologia
collection Jornal Brasileiro de Nefrologia
repository.name.fl_str_mv Jornal Brasileiro de Nefrologia - Sociedade Brasileira de Nefrologia (SBN)
repository.mail.fl_str_mv ||jbn@sbn.org.br
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