The impact of transient and persistent acute kidney injury in hospital mortality in COVID-19 patients

Detalhes bibliográficos
Autor(a) principal: Bernardo,João
Data de Publicação: 2022
Outros Autores: Gonçalves,Joana, Gameiro,Joana, Oliveira,João, Marques,Filipe, Duarte,Inês, Branco,Carolina, Costa,Claudia, Carreiro,Carolina, Fonseca,José Nuno, Braz,Sandra, Lopes,José António
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Jornal Brasileiro de Nefrologia
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0101-28002022000300310
Resumo: Abstract Introduction: Acute kidney injury (AKI) has been described in Coronavirus Disease 2019 (COVID-19) patients and is considered a marker of disease severity and a negative prognostic factor for survival. In this study, the authors aimed to study the impact of transient and persistent acute kidney injury (pAKI) on in-hospital mortality in COVID-19 patients. Methods: This was a retrospective observational study of patients hospitalized with COVID-19 in the Department of Medicine of the Centro Hospitalar Universitario Lisboa Norte, Lisbon, Portugal, between March 2020 and August 2020. A multivariate analysis was performed to predict AKI development and in-hospital mortality. Results: Of 544 patients with COVID-19, 330 developed AKI: 166 persistent AKI (pAKI), 164 with transient AKI. AKI patients were older, had more previous comorbidities, had higher need to be medicated with RAAS inhibitors, had higher baseline serum creatine (SCr) (1.60 mg/dL vs 0.87 mg/dL), higher NL ratio, and more severe acidemia on hospital admission, and more frequently required admission in intensive care unit, mechanical ventilation, and vasopressor use. Patients with persistent AKI had higher SCr level (1.71 mg/dL vs 1.25 mg/dL) on hospital admission. In-hospital mortality was 14.0% and it was higher in AKI patients (18.5% vs 7.0%). CKD and serum ferritin were independent predictors of AKI. AKI did not predict mortality, but pAKI was an independent predictor of mortality, as was age and lactate level. Conclusion: pAKI was independently associated with in-hospital mortality in COVID-19 patients but its impact on long-term follow-up remains to be determined.
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spelling The impact of transient and persistent acute kidney injury in hospital mortality in COVID-19 patientsAcute Kidney InjuryCOVID-19, SARS-CoV-2Hospital MortalityAbstract Introduction: Acute kidney injury (AKI) has been described in Coronavirus Disease 2019 (COVID-19) patients and is considered a marker of disease severity and a negative prognostic factor for survival. In this study, the authors aimed to study the impact of transient and persistent acute kidney injury (pAKI) on in-hospital mortality in COVID-19 patients. Methods: This was a retrospective observational study of patients hospitalized with COVID-19 in the Department of Medicine of the Centro Hospitalar Universitario Lisboa Norte, Lisbon, Portugal, between March 2020 and August 2020. A multivariate analysis was performed to predict AKI development and in-hospital mortality. Results: Of 544 patients with COVID-19, 330 developed AKI: 166 persistent AKI (pAKI), 164 with transient AKI. AKI patients were older, had more previous comorbidities, had higher need to be medicated with RAAS inhibitors, had higher baseline serum creatine (SCr) (1.60 mg/dL vs 0.87 mg/dL), higher NL ratio, and more severe acidemia on hospital admission, and more frequently required admission in intensive care unit, mechanical ventilation, and vasopressor use. Patients with persistent AKI had higher SCr level (1.71 mg/dL vs 1.25 mg/dL) on hospital admission. In-hospital mortality was 14.0% and it was higher in AKI patients (18.5% vs 7.0%). CKD and serum ferritin were independent predictors of AKI. AKI did not predict mortality, but pAKI was an independent predictor of mortality, as was age and lactate level. Conclusion: pAKI was independently associated with in-hospital mortality in COVID-19 patients but its impact on long-term follow-up remains to be determined.Sociedade Brasileira de Nefrologia2022-09-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0101-28002022000300310Brazilian Journal of Nephrology v.44 n.3 2022reponame:Jornal Brasileiro de Nefrologiainstname:Sociedade Brasileira de Nefrologia (SBN)instacron:SBN10.1590/2175-8239-jbn-2021-0123info:eu-repo/semantics/openAccessBernardo,JoãoGonçalves,JoanaGameiro,JoanaOliveira,JoãoMarques,FilipeDuarte,InêsBranco,CarolinaCosta,ClaudiaCarreiro,CarolinaFonseca,José NunoBraz,SandraLopes,José Antónioeng2022-09-23T00:00:00Zoai:scielo:S0101-28002022000300310Revistahttp://www.bjn.org.br/ONGhttps://old.scielo.br/oai/scielo-oai.php||jbn@sbn.org.br2175-82390101-2800opendoar:2022-09-23T00:00Jornal Brasileiro de Nefrologia - Sociedade Brasileira de Nefrologia (SBN)false
dc.title.none.fl_str_mv The impact of transient and persistent acute kidney injury in hospital mortality in COVID-19 patients
title The impact of transient and persistent acute kidney injury in hospital mortality in COVID-19 patients
spellingShingle The impact of transient and persistent acute kidney injury in hospital mortality in COVID-19 patients
Bernardo,João
Acute Kidney Injury
COVID-19, SARS-CoV-2
Hospital Mortality
title_short The impact of transient and persistent acute kidney injury in hospital mortality in COVID-19 patients
title_full The impact of transient and persistent acute kidney injury in hospital mortality in COVID-19 patients
title_fullStr The impact of transient and persistent acute kidney injury in hospital mortality in COVID-19 patients
title_full_unstemmed The impact of transient and persistent acute kidney injury in hospital mortality in COVID-19 patients
title_sort The impact of transient and persistent acute kidney injury in hospital mortality in COVID-19 patients
author Bernardo,João
author_facet Bernardo,João
Gonçalves,Joana
Gameiro,Joana
Oliveira,João
Marques,Filipe
Duarte,Inês
Branco,Carolina
Costa,Claudia
Carreiro,Carolina
Fonseca,José Nuno
Braz,Sandra
Lopes,José António
author_role author
author2 Gonçalves,Joana
Gameiro,Joana
Oliveira,João
Marques,Filipe
Duarte,Inês
Branco,Carolina
Costa,Claudia
Carreiro,Carolina
Fonseca,José Nuno
Braz,Sandra
Lopes,José António
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Bernardo,João
Gonçalves,Joana
Gameiro,Joana
Oliveira,João
Marques,Filipe
Duarte,Inês
Branco,Carolina
Costa,Claudia
Carreiro,Carolina
Fonseca,José Nuno
Braz,Sandra
Lopes,José António
dc.subject.por.fl_str_mv Acute Kidney Injury
COVID-19, SARS-CoV-2
Hospital Mortality
topic Acute Kidney Injury
COVID-19, SARS-CoV-2
Hospital Mortality
description Abstract Introduction: Acute kidney injury (AKI) has been described in Coronavirus Disease 2019 (COVID-19) patients and is considered a marker of disease severity and a negative prognostic factor for survival. In this study, the authors aimed to study the impact of transient and persistent acute kidney injury (pAKI) on in-hospital mortality in COVID-19 patients. Methods: This was a retrospective observational study of patients hospitalized with COVID-19 in the Department of Medicine of the Centro Hospitalar Universitario Lisboa Norte, Lisbon, Portugal, between March 2020 and August 2020. A multivariate analysis was performed to predict AKI development and in-hospital mortality. Results: Of 544 patients with COVID-19, 330 developed AKI: 166 persistent AKI (pAKI), 164 with transient AKI. AKI patients were older, had more previous comorbidities, had higher need to be medicated with RAAS inhibitors, had higher baseline serum creatine (SCr) (1.60 mg/dL vs 0.87 mg/dL), higher NL ratio, and more severe acidemia on hospital admission, and more frequently required admission in intensive care unit, mechanical ventilation, and vasopressor use. Patients with persistent AKI had higher SCr level (1.71 mg/dL vs 1.25 mg/dL) on hospital admission. In-hospital mortality was 14.0% and it was higher in AKI patients (18.5% vs 7.0%). CKD and serum ferritin were independent predictors of AKI. AKI did not predict mortality, but pAKI was an independent predictor of mortality, as was age and lactate level. Conclusion: pAKI was independently associated with in-hospital mortality in COVID-19 patients but its impact on long-term follow-up remains to be determined.
publishDate 2022
dc.date.none.fl_str_mv 2022-09-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
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dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/2175-8239-jbn-2021-0123
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
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dc.publisher.none.fl_str_mv Sociedade Brasileira de Nefrologia
publisher.none.fl_str_mv Sociedade Brasileira de Nefrologia
dc.source.none.fl_str_mv Brazilian Journal of Nephrology v.44 n.3 2022
reponame:Jornal Brasileiro de Nefrologia
instname:Sociedade Brasileira de Nefrologia (SBN)
instacron:SBN
instname_str Sociedade Brasileira de Nefrologia (SBN)
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reponame_str Jornal Brasileiro de Nefrologia
collection Jornal Brasileiro de Nefrologia
repository.name.fl_str_mv Jornal Brasileiro de Nefrologia - Sociedade Brasileira de Nefrologia (SBN)
repository.mail.fl_str_mv ||jbn@sbn.org.br
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