Early changes in serum albumin: impact on 2-year mortality in incident hemodialysis patients

Detalhes bibliográficos
Autor(a) principal: Pereira,Giselly Rosa Modesto
Data de Publicação: 2015
Outros Autores: Strogoff-de-Matos,Jorge Paulo, Ruzany,Frederico, Santos,Sergio Fernando Ferreira dos, D'Almeida Filho,Eufrônio, Vasconcelos,Marcos Sandro Fernandes de, Barra,Ana Beatriz, Lugon,Jocemir Ronaldo
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Jornal Brasileiro de Nefrologia
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0101-28002015000200198
Resumo: Abstract Introduction/objective: We evaluated the predictability of early changes in serum albumin (sAlb) on the two-year mortality of incident hemodialysis patients. Methods: Observational, longitudinal retrospective study using the database of Fresenius Medical Care of Latin America. Adult patients starting dialysis from January/2000 to June/2004, from 25 centers were included. Changes in sAlb during the first 3 months on hemodialysis were used as the main predictor. The outcome was death from any cause. Results: 1,679 incident patients were included. They were 52 ± 15 years old, 58.7% male and 21.5% diabetic, with a median sAlb of 38 g/L (bromocresol green). 923 patients had sAlb < 38 g/L (Low sAlb Group) and 756 ones had sAlb > 38.0 g/L (Adequate sAlb Group). The mortality was significantly higher in Low sAlb Group (17% vs. 11%, p < 0.001). Early changes in sAlb significantly affected two-year mortality. Factoring the Kaplan Meier curve of Low sAlb Group by the presence of an increase in sAlb uncovered of a statistically significant difference in mortality favoring the ones whose sAlb went up (19% vs. 15%, p = 0.043). Differently, patients from Adequate sAlb Group with a decrease in their sAlb had a statistically higher mortality rate (13% vs. 8%, p = 0.029). Conclusions: Early sAlb changes showed a significant predictive power on mortality at 2 years in incident hemodialysis patients. Those with low initial sAlb may have a better prognosis if their sAlb rises. In contrast, patients with satisfactory initial levels can have a worsening of their prognosis in the case of an early reduction in sAlb.
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spelling Early changes in serum albumin: impact on 2-year mortality in incident hemodialysis patientskidney failure, chronicmortalityrenal dialysisserum albuminAbstract Introduction/objective: We evaluated the predictability of early changes in serum albumin (sAlb) on the two-year mortality of incident hemodialysis patients. Methods: Observational, longitudinal retrospective study using the database of Fresenius Medical Care of Latin America. Adult patients starting dialysis from January/2000 to June/2004, from 25 centers were included. Changes in sAlb during the first 3 months on hemodialysis were used as the main predictor. The outcome was death from any cause. Results: 1,679 incident patients were included. They were 52 ± 15 years old, 58.7% male and 21.5% diabetic, with a median sAlb of 38 g/L (bromocresol green). 923 patients had sAlb < 38 g/L (Low sAlb Group) and 756 ones had sAlb > 38.0 g/L (Adequate sAlb Group). The mortality was significantly higher in Low sAlb Group (17% vs. 11%, p < 0.001). Early changes in sAlb significantly affected two-year mortality. Factoring the Kaplan Meier curve of Low sAlb Group by the presence of an increase in sAlb uncovered of a statistically significant difference in mortality favoring the ones whose sAlb went up (19% vs. 15%, p = 0.043). Differently, patients from Adequate sAlb Group with a decrease in their sAlb had a statistically higher mortality rate (13% vs. 8%, p = 0.029). Conclusions: Early sAlb changes showed a significant predictive power on mortality at 2 years in incident hemodialysis patients. Those with low initial sAlb may have a better prognosis if their sAlb rises. In contrast, patients with satisfactory initial levels can have a worsening of their prognosis in the case of an early reduction in sAlb.Sociedade Brasileira de Nefrologia2015-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0101-28002015000200198Brazilian Journal of Nephrology v.37 n.2 2015reponame:Jornal Brasileiro de Nefrologiainstname:Sociedade Brasileira de Nefrologia (SBN)instacron:SBN10.5935/0101-2800.20150032info:eu-repo/semantics/openAccessPereira,Giselly Rosa ModestoStrogoff-de-Matos,Jorge PauloRuzany,FredericoSantos,Sergio Fernando Ferreira dosD'Almeida Filho,EufrônioVasconcelos,Marcos Sandro Fernandes deBarra,Ana BeatrizLugon,Jocemir Ronaldoeng2016-12-19T00:00:00Zoai:scielo:S0101-28002015000200198Revistahttp://www.bjn.org.br/ONGhttps://old.scielo.br/oai/scielo-oai.php||jbn@sbn.org.br2175-82390101-2800opendoar:2016-12-19T00:00Jornal Brasileiro de Nefrologia - Sociedade Brasileira de Nefrologia (SBN)false
dc.title.none.fl_str_mv Early changes in serum albumin: impact on 2-year mortality in incident hemodialysis patients
title Early changes in serum albumin: impact on 2-year mortality in incident hemodialysis patients
spellingShingle Early changes in serum albumin: impact on 2-year mortality in incident hemodialysis patients
Pereira,Giselly Rosa Modesto
kidney failure, chronic
mortality
renal dialysis
serum albumin
title_short Early changes in serum albumin: impact on 2-year mortality in incident hemodialysis patients
title_full Early changes in serum albumin: impact on 2-year mortality in incident hemodialysis patients
title_fullStr Early changes in serum albumin: impact on 2-year mortality in incident hemodialysis patients
title_full_unstemmed Early changes in serum albumin: impact on 2-year mortality in incident hemodialysis patients
title_sort Early changes in serum albumin: impact on 2-year mortality in incident hemodialysis patients
author Pereira,Giselly Rosa Modesto
author_facet Pereira,Giselly Rosa Modesto
Strogoff-de-Matos,Jorge Paulo
Ruzany,Frederico
Santos,Sergio Fernando Ferreira dos
D'Almeida Filho,Eufrônio
Vasconcelos,Marcos Sandro Fernandes de
Barra,Ana Beatriz
Lugon,Jocemir Ronaldo
author_role author
author2 Strogoff-de-Matos,Jorge Paulo
Ruzany,Frederico
Santos,Sergio Fernando Ferreira dos
D'Almeida Filho,Eufrônio
Vasconcelos,Marcos Sandro Fernandes de
Barra,Ana Beatriz
Lugon,Jocemir Ronaldo
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Pereira,Giselly Rosa Modesto
Strogoff-de-Matos,Jorge Paulo
Ruzany,Frederico
Santos,Sergio Fernando Ferreira dos
D'Almeida Filho,Eufrônio
Vasconcelos,Marcos Sandro Fernandes de
Barra,Ana Beatriz
Lugon,Jocemir Ronaldo
dc.subject.por.fl_str_mv kidney failure, chronic
mortality
renal dialysis
serum albumin
topic kidney failure, chronic
mortality
renal dialysis
serum albumin
description Abstract Introduction/objective: We evaluated the predictability of early changes in serum albumin (sAlb) on the two-year mortality of incident hemodialysis patients. Methods: Observational, longitudinal retrospective study using the database of Fresenius Medical Care of Latin America. Adult patients starting dialysis from January/2000 to June/2004, from 25 centers were included. Changes in sAlb during the first 3 months on hemodialysis were used as the main predictor. The outcome was death from any cause. Results: 1,679 incident patients were included. They were 52 ± 15 years old, 58.7% male and 21.5% diabetic, with a median sAlb of 38 g/L (bromocresol green). 923 patients had sAlb < 38 g/L (Low sAlb Group) and 756 ones had sAlb > 38.0 g/L (Adequate sAlb Group). The mortality was significantly higher in Low sAlb Group (17% vs. 11%, p < 0.001). Early changes in sAlb significantly affected two-year mortality. Factoring the Kaplan Meier curve of Low sAlb Group by the presence of an increase in sAlb uncovered of a statistically significant difference in mortality favoring the ones whose sAlb went up (19% vs. 15%, p = 0.043). Differently, patients from Adequate sAlb Group with a decrease in their sAlb had a statistically higher mortality rate (13% vs. 8%, p = 0.029). Conclusions: Early sAlb changes showed a significant predictive power on mortality at 2 years in incident hemodialysis patients. Those with low initial sAlb may have a better prognosis if their sAlb rises. In contrast, patients with satisfactory initial levels can have a worsening of their prognosis in the case of an early reduction in sAlb.
publishDate 2015
dc.date.none.fl_str_mv 2015-06-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
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dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0101-28002015000200198
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0101-28002015000200198
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.5935/0101-2800.20150032
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
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dc.publisher.none.fl_str_mv Sociedade Brasileira de Nefrologia
publisher.none.fl_str_mv Sociedade Brasileira de Nefrologia
dc.source.none.fl_str_mv Brazilian Journal of Nephrology v.37 n.2 2015
reponame:Jornal Brasileiro de Nefrologia
instname:Sociedade Brasileira de Nefrologia (SBN)
instacron:SBN
instname_str Sociedade Brasileira de Nefrologia (SBN)
instacron_str SBN
institution SBN
reponame_str Jornal Brasileiro de Nefrologia
collection Jornal Brasileiro de Nefrologia
repository.name.fl_str_mv Jornal Brasileiro de Nefrologia - Sociedade Brasileira de Nefrologia (SBN)
repository.mail.fl_str_mv ||jbn@sbn.org.br
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