Cathepsin S as an early biomarker for cardiovascular disease in chronic kidney disease patients
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Jornal Brasileiro de Nefrologia |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0101-28002022000300329 |
Resumo: | Abstract Introduction: A high incidence of cardiovascular disease (CVD) events and premature mortality is observed in patients with chronic kidney disease (CKD). Thus, new biomarkers that may help predict the development of CVD in early stages of CKD are being investigated along with other traditional risk factors. Objective: To investigate cathepsin S as an early biomarker for CVD in patients with CKD. Methods: A total of 64 patients with CKD were included and classified into 2 groups: CKD patients with established CVD and CKD patients with non-established CVD. All patients were submitted to routine investigations including complete blood count, random blood sugar, glycated hemoglobin (HbA1c), serum electrolytes, urea, creatinine, total protein, total albumin, calcium total, phosphorous, uric acid, vitamin D, parathormone, lipid profile, liver function test, measurement of serum cathepsin S (Cat S), and 2D Echo of the heart. Results: The level of serum Cat S was increased in CKD patients with CVD (p <0.05) as well as in later stages of CKD (p <0.05). CVD was also more common in patients in early stage CKD. In early stages CKD, Cat S and CVD were positively correlated. Conclusion: These findings suggest that serum Cat S might be useful as an early biomarker for CVD in CKD patients. |
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Cathepsin S as an early biomarker for cardiovascular disease in chronic kidney disease patientsDiabetes MellitusHypertensionEchocardiographyAtherosclerosisArteriosclerosisAbstract Introduction: A high incidence of cardiovascular disease (CVD) events and premature mortality is observed in patients with chronic kidney disease (CKD). Thus, new biomarkers that may help predict the development of CVD in early stages of CKD are being investigated along with other traditional risk factors. Objective: To investigate cathepsin S as an early biomarker for CVD in patients with CKD. Methods: A total of 64 patients with CKD were included and classified into 2 groups: CKD patients with established CVD and CKD patients with non-established CVD. All patients were submitted to routine investigations including complete blood count, random blood sugar, glycated hemoglobin (HbA1c), serum electrolytes, urea, creatinine, total protein, total albumin, calcium total, phosphorous, uric acid, vitamin D, parathormone, lipid profile, liver function test, measurement of serum cathepsin S (Cat S), and 2D Echo of the heart. Results: The level of serum Cat S was increased in CKD patients with CVD (p <0.05) as well as in later stages of CKD (p <0.05). CVD was also more common in patients in early stage CKD. In early stages CKD, Cat S and CVD were positively correlated. Conclusion: These findings suggest that serum Cat S might be useful as an early biomarker for CVD in CKD patients.Sociedade Brasileira de Nefrologia2022-09-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0101-28002022000300329Brazilian Journal of Nephrology v.44 n.3 2022reponame:Jornal Brasileiro de Nefrologiainstname:Sociedade Brasileira de Nefrologia (SBN)instacron:SBN10.1590/2175-8239-jbn-2021-0135info:eu-repo/semantics/openAccessSonkar,Satyendra KumarSingh,Prashant KumarChandra,SharadSonkar,Gyanendra KumarBhosale,VivekSharma,Sharadeng2022-09-23T00:00:00Zoai:scielo:S0101-28002022000300329Revistahttp://www.bjn.org.br/ONGhttps://old.scielo.br/oai/scielo-oai.php||jbn@sbn.org.br2175-82390101-2800opendoar:2022-09-23T00:00Jornal Brasileiro de Nefrologia - Sociedade Brasileira de Nefrologia (SBN)false |
dc.title.none.fl_str_mv |
Cathepsin S as an early biomarker for cardiovascular disease in chronic kidney disease patients |
title |
Cathepsin S as an early biomarker for cardiovascular disease in chronic kidney disease patients |
spellingShingle |
Cathepsin S as an early biomarker for cardiovascular disease in chronic kidney disease patients Sonkar,Satyendra Kumar Diabetes Mellitus Hypertension Echocardiography Atherosclerosis Arteriosclerosis |
title_short |
Cathepsin S as an early biomarker for cardiovascular disease in chronic kidney disease patients |
title_full |
Cathepsin S as an early biomarker for cardiovascular disease in chronic kidney disease patients |
title_fullStr |
Cathepsin S as an early biomarker for cardiovascular disease in chronic kidney disease patients |
title_full_unstemmed |
Cathepsin S as an early biomarker for cardiovascular disease in chronic kidney disease patients |
title_sort |
Cathepsin S as an early biomarker for cardiovascular disease in chronic kidney disease patients |
author |
Sonkar,Satyendra Kumar |
author_facet |
Sonkar,Satyendra Kumar Singh,Prashant Kumar Chandra,Sharad Sonkar,Gyanendra Kumar Bhosale,Vivek Sharma,Sharad |
author_role |
author |
author2 |
Singh,Prashant Kumar Chandra,Sharad Sonkar,Gyanendra Kumar Bhosale,Vivek Sharma,Sharad |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Sonkar,Satyendra Kumar Singh,Prashant Kumar Chandra,Sharad Sonkar,Gyanendra Kumar Bhosale,Vivek Sharma,Sharad |
dc.subject.por.fl_str_mv |
Diabetes Mellitus Hypertension Echocardiography Atherosclerosis Arteriosclerosis |
topic |
Diabetes Mellitus Hypertension Echocardiography Atherosclerosis Arteriosclerosis |
description |
Abstract Introduction: A high incidence of cardiovascular disease (CVD) events and premature mortality is observed in patients with chronic kidney disease (CKD). Thus, new biomarkers that may help predict the development of CVD in early stages of CKD are being investigated along with other traditional risk factors. Objective: To investigate cathepsin S as an early biomarker for CVD in patients with CKD. Methods: A total of 64 patients with CKD were included and classified into 2 groups: CKD patients with established CVD and CKD patients with non-established CVD. All patients were submitted to routine investigations including complete blood count, random blood sugar, glycated hemoglobin (HbA1c), serum electrolytes, urea, creatinine, total protein, total albumin, calcium total, phosphorous, uric acid, vitamin D, parathormone, lipid profile, liver function test, measurement of serum cathepsin S (Cat S), and 2D Echo of the heart. Results: The level of serum Cat S was increased in CKD patients with CVD (p <0.05) as well as in later stages of CKD (p <0.05). CVD was also more common in patients in early stage CKD. In early stages CKD, Cat S and CVD were positively correlated. Conclusion: These findings suggest that serum Cat S might be useful as an early biomarker for CVD in CKD patients. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-09-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0101-28002022000300329 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0101-28002022000300329 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/2175-8239-jbn-2021-0135 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Nefrologia |
publisher.none.fl_str_mv |
Sociedade Brasileira de Nefrologia |
dc.source.none.fl_str_mv |
Brazilian Journal of Nephrology v.44 n.3 2022 reponame:Jornal Brasileiro de Nefrologia instname:Sociedade Brasileira de Nefrologia (SBN) instacron:SBN |
instname_str |
Sociedade Brasileira de Nefrologia (SBN) |
instacron_str |
SBN |
institution |
SBN |
reponame_str |
Jornal Brasileiro de Nefrologia |
collection |
Jornal Brasileiro de Nefrologia |
repository.name.fl_str_mv |
Jornal Brasileiro de Nefrologia - Sociedade Brasileira de Nefrologia (SBN) |
repository.mail.fl_str_mv |
||jbn@sbn.org.br |
_version_ |
1752122067595034624 |