Pp65 antigenemia and cytomegalovirus diagnosis in patients with lupus nephritis: report of a series.
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Jornal Brasileiro de Nefrologia |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0101-28002018000100044 |
Resumo: | ABSTRACT Introduction: In contrast to organ transplantation, few studies correlate the monitoring of pp65 antigenemia with a diagnosis of cytomegalovirus (CMV) in patients with systemic lupus erythematosus (SLE). Objective: To highlight the importance of CMV outside transplantation, we monitored pp65 antigenemia in a series of SLE patients. Methods: From March 2015 to March 2016, SLE patients presenting kidney involvement, fever, and an unclear infection at hospital admission were monitored through pp65 antigenemia. The pp65 antigenemia assay, revealed by immunofluorescence, was correlated with clinical and laboratory findings. Results: We included 19 patients with a suspected unclear infection. A positivity for pp65 antigenemia was found in seven patients (36.8%). The mean age was 33.5 ± 11.2 years, 16 (84%) were females, and 16 (84%) were black. Lymphopenia, anemia, and higher scores of SLEDAI were significantly more common in pp65-positive patients. Five patients received antiviral therapy with ganciclovir. Although receiving specific CMV treatment, one patient died because of suspected CMV disease. Conclusions: Pp65 antigenemia might be relevant in SLE patients, and studies with a greater number of patients are needed in order to establish sensitivity and specificity of pp65 antigenemia in different clinical contexts of SLE patients. |
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Pp65 antigenemia and cytomegalovirus diagnosis in patients with lupus nephritis: report of a series.Lupus Erythematosus, SystemicCytomegalovirusViremiaABSTRACT Introduction: In contrast to organ transplantation, few studies correlate the monitoring of pp65 antigenemia with a diagnosis of cytomegalovirus (CMV) in patients with systemic lupus erythematosus (SLE). Objective: To highlight the importance of CMV outside transplantation, we monitored pp65 antigenemia in a series of SLE patients. Methods: From March 2015 to March 2016, SLE patients presenting kidney involvement, fever, and an unclear infection at hospital admission were monitored through pp65 antigenemia. The pp65 antigenemia assay, revealed by immunofluorescence, was correlated with clinical and laboratory findings. Results: We included 19 patients with a suspected unclear infection. A positivity for pp65 antigenemia was found in seven patients (36.8%). The mean age was 33.5 ± 11.2 years, 16 (84%) were females, and 16 (84%) were black. Lymphopenia, anemia, and higher scores of SLEDAI were significantly more common in pp65-positive patients. Five patients received antiviral therapy with ganciclovir. Although receiving specific CMV treatment, one patient died because of suspected CMV disease. Conclusions: Pp65 antigenemia might be relevant in SLE patients, and studies with a greater number of patients are needed in order to establish sensitivity and specificity of pp65 antigenemia in different clinical contexts of SLE patients.Sociedade Brasileira de Nefrologia2018-03-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0101-28002018000100044Brazilian Journal of Nephrology v.40 n.1 2018reponame:Jornal Brasileiro de Nefrologiainstname:Sociedade Brasileira de Nefrologia (SBN)instacron:SBN10.1590/2175-8239-jbn-3838info:eu-repo/semantics/openAccessLino,KatiaTrizzotti,NataliaCarvalho,Fabiana RabeCosendey,Rachel IngridSouza,Cintia FernandesKlumb,Evandro MendesSilva,Andrea AliceAlmeida,Jorge Reiseng2018-05-11T00:00:00Zoai:scielo:S0101-28002018000100044Revistahttp://www.bjn.org.br/ONGhttps://old.scielo.br/oai/scielo-oai.php||jbn@sbn.org.br2175-82390101-2800opendoar:2018-05-11T00:00Jornal Brasileiro de Nefrologia - Sociedade Brasileira de Nefrologia (SBN)false |
dc.title.none.fl_str_mv |
Pp65 antigenemia and cytomegalovirus diagnosis in patients with lupus nephritis: report of a series. |
title |
Pp65 antigenemia and cytomegalovirus diagnosis in patients with lupus nephritis: report of a series. |
spellingShingle |
Pp65 antigenemia and cytomegalovirus diagnosis in patients with lupus nephritis: report of a series. Lino,Katia Lupus Erythematosus, Systemic Cytomegalovirus Viremia |
title_short |
Pp65 antigenemia and cytomegalovirus diagnosis in patients with lupus nephritis: report of a series. |
title_full |
Pp65 antigenemia and cytomegalovirus diagnosis in patients with lupus nephritis: report of a series. |
title_fullStr |
Pp65 antigenemia and cytomegalovirus diagnosis in patients with lupus nephritis: report of a series. |
title_full_unstemmed |
Pp65 antigenemia and cytomegalovirus diagnosis in patients with lupus nephritis: report of a series. |
title_sort |
Pp65 antigenemia and cytomegalovirus diagnosis in patients with lupus nephritis: report of a series. |
author |
Lino,Katia |
author_facet |
Lino,Katia Trizzotti,Natalia Carvalho,Fabiana Rabe Cosendey,Rachel Ingrid Souza,Cintia Fernandes Klumb,Evandro Mendes Silva,Andrea Alice Almeida,Jorge Reis |
author_role |
author |
author2 |
Trizzotti,Natalia Carvalho,Fabiana Rabe Cosendey,Rachel Ingrid Souza,Cintia Fernandes Klumb,Evandro Mendes Silva,Andrea Alice Almeida,Jorge Reis |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Lino,Katia Trizzotti,Natalia Carvalho,Fabiana Rabe Cosendey,Rachel Ingrid Souza,Cintia Fernandes Klumb,Evandro Mendes Silva,Andrea Alice Almeida,Jorge Reis |
dc.subject.por.fl_str_mv |
Lupus Erythematosus, Systemic Cytomegalovirus Viremia |
topic |
Lupus Erythematosus, Systemic Cytomegalovirus Viremia |
description |
ABSTRACT Introduction: In contrast to organ transplantation, few studies correlate the monitoring of pp65 antigenemia with a diagnosis of cytomegalovirus (CMV) in patients with systemic lupus erythematosus (SLE). Objective: To highlight the importance of CMV outside transplantation, we monitored pp65 antigenemia in a series of SLE patients. Methods: From March 2015 to March 2016, SLE patients presenting kidney involvement, fever, and an unclear infection at hospital admission were monitored through pp65 antigenemia. The pp65 antigenemia assay, revealed by immunofluorescence, was correlated with clinical and laboratory findings. Results: We included 19 patients with a suspected unclear infection. A positivity for pp65 antigenemia was found in seven patients (36.8%). The mean age was 33.5 ± 11.2 years, 16 (84%) were females, and 16 (84%) were black. Lymphopenia, anemia, and higher scores of SLEDAI were significantly more common in pp65-positive patients. Five patients received antiviral therapy with ganciclovir. Although receiving specific CMV treatment, one patient died because of suspected CMV disease. Conclusions: Pp65 antigenemia might be relevant in SLE patients, and studies with a greater number of patients are needed in order to establish sensitivity and specificity of pp65 antigenemia in different clinical contexts of SLE patients. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-03-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0101-28002018000100044 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0101-28002018000100044 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/2175-8239-jbn-3838 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Nefrologia |
publisher.none.fl_str_mv |
Sociedade Brasileira de Nefrologia |
dc.source.none.fl_str_mv |
Brazilian Journal of Nephrology v.40 n.1 2018 reponame:Jornal Brasileiro de Nefrologia instname:Sociedade Brasileira de Nefrologia (SBN) instacron:SBN |
instname_str |
Sociedade Brasileira de Nefrologia (SBN) |
instacron_str |
SBN |
institution |
SBN |
reponame_str |
Jornal Brasileiro de Nefrologia |
collection |
Jornal Brasileiro de Nefrologia |
repository.name.fl_str_mv |
Jornal Brasileiro de Nefrologia - Sociedade Brasileira de Nefrologia (SBN) |
repository.mail.fl_str_mv |
||jbn@sbn.org.br |
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1752122064633856000 |