Pp65 antigenemia and cytomegalovirus diagnosis in patients with lupus nephritis: report of a series.

Detalhes bibliográficos
Autor(a) principal: Lino,Katia
Data de Publicação: 2018
Outros Autores: Trizzotti,Natalia, Carvalho,Fabiana Rabe, Cosendey,Rachel Ingrid, Souza,Cintia Fernandes, Klumb,Evandro Mendes, Silva,Andrea Alice, Almeida,Jorge Reis
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Jornal Brasileiro de Nefrologia
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0101-28002018000100044
Resumo: ABSTRACT Introduction: In contrast to organ transplantation, few studies correlate the monitoring of pp65 antigenemia with a diagnosis of cytomegalovirus (CMV) in patients with systemic lupus erythematosus (SLE). Objective: To highlight the importance of CMV outside transplantation, we monitored pp65 antigenemia in a series of SLE patients. Methods: From March 2015 to March 2016, SLE patients presenting kidney involvement, fever, and an unclear infection at hospital admission were monitored through pp65 antigenemia. The pp65 antigenemia assay, revealed by immunofluorescence, was correlated with clinical and laboratory findings. Results: We included 19 patients with a suspected unclear infection. A positivity for pp65 antigenemia was found in seven patients (36.8%). The mean age was 33.5 ± 11.2 years, 16 (84%) were females, and 16 (84%) were black. Lymphopenia, anemia, and higher scores of SLEDAI were significantly more common in pp65-positive patients. Five patients received antiviral therapy with ganciclovir. Although receiving specific CMV treatment, one patient died because of suspected CMV disease. Conclusions: Pp65 antigenemia might be relevant in SLE patients, and studies with a greater number of patients are needed in order to establish sensitivity and specificity of pp65 antigenemia in different clinical contexts of SLE patients.
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spelling Pp65 antigenemia and cytomegalovirus diagnosis in patients with lupus nephritis: report of a series.Lupus Erythematosus, SystemicCytomegalovirusViremiaABSTRACT Introduction: In contrast to organ transplantation, few studies correlate the monitoring of pp65 antigenemia with a diagnosis of cytomegalovirus (CMV) in patients with systemic lupus erythematosus (SLE). Objective: To highlight the importance of CMV outside transplantation, we monitored pp65 antigenemia in a series of SLE patients. Methods: From March 2015 to March 2016, SLE patients presenting kidney involvement, fever, and an unclear infection at hospital admission were monitored through pp65 antigenemia. The pp65 antigenemia assay, revealed by immunofluorescence, was correlated with clinical and laboratory findings. Results: We included 19 patients with a suspected unclear infection. A positivity for pp65 antigenemia was found in seven patients (36.8%). The mean age was 33.5 ± 11.2 years, 16 (84%) were females, and 16 (84%) were black. Lymphopenia, anemia, and higher scores of SLEDAI were significantly more common in pp65-positive patients. Five patients received antiviral therapy with ganciclovir. Although receiving specific CMV treatment, one patient died because of suspected CMV disease. Conclusions: Pp65 antigenemia might be relevant in SLE patients, and studies with a greater number of patients are needed in order to establish sensitivity and specificity of pp65 antigenemia in different clinical contexts of SLE patients.Sociedade Brasileira de Nefrologia2018-03-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0101-28002018000100044Brazilian Journal of Nephrology v.40 n.1 2018reponame:Jornal Brasileiro de Nefrologiainstname:Sociedade Brasileira de Nefrologia (SBN)instacron:SBN10.1590/2175-8239-jbn-3838info:eu-repo/semantics/openAccessLino,KatiaTrizzotti,NataliaCarvalho,Fabiana RabeCosendey,Rachel IngridSouza,Cintia FernandesKlumb,Evandro MendesSilva,Andrea AliceAlmeida,Jorge Reiseng2018-05-11T00:00:00Zoai:scielo:S0101-28002018000100044Revistahttp://www.bjn.org.br/ONGhttps://old.scielo.br/oai/scielo-oai.php||jbn@sbn.org.br2175-82390101-2800opendoar:2018-05-11T00:00Jornal Brasileiro de Nefrologia - Sociedade Brasileira de Nefrologia (SBN)false
dc.title.none.fl_str_mv Pp65 antigenemia and cytomegalovirus diagnosis in patients with lupus nephritis: report of a series.
title Pp65 antigenemia and cytomegalovirus diagnosis in patients with lupus nephritis: report of a series.
spellingShingle Pp65 antigenemia and cytomegalovirus diagnosis in patients with lupus nephritis: report of a series.
Lino,Katia
Lupus Erythematosus, Systemic
Cytomegalovirus
Viremia
title_short Pp65 antigenemia and cytomegalovirus diagnosis in patients with lupus nephritis: report of a series.
title_full Pp65 antigenemia and cytomegalovirus diagnosis in patients with lupus nephritis: report of a series.
title_fullStr Pp65 antigenemia and cytomegalovirus diagnosis in patients with lupus nephritis: report of a series.
title_full_unstemmed Pp65 antigenemia and cytomegalovirus diagnosis in patients with lupus nephritis: report of a series.
title_sort Pp65 antigenemia and cytomegalovirus diagnosis in patients with lupus nephritis: report of a series.
author Lino,Katia
author_facet Lino,Katia
Trizzotti,Natalia
Carvalho,Fabiana Rabe
Cosendey,Rachel Ingrid
Souza,Cintia Fernandes
Klumb,Evandro Mendes
Silva,Andrea Alice
Almeida,Jorge Reis
author_role author
author2 Trizzotti,Natalia
Carvalho,Fabiana Rabe
Cosendey,Rachel Ingrid
Souza,Cintia Fernandes
Klumb,Evandro Mendes
Silva,Andrea Alice
Almeida,Jorge Reis
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Lino,Katia
Trizzotti,Natalia
Carvalho,Fabiana Rabe
Cosendey,Rachel Ingrid
Souza,Cintia Fernandes
Klumb,Evandro Mendes
Silva,Andrea Alice
Almeida,Jorge Reis
dc.subject.por.fl_str_mv Lupus Erythematosus, Systemic
Cytomegalovirus
Viremia
topic Lupus Erythematosus, Systemic
Cytomegalovirus
Viremia
description ABSTRACT Introduction: In contrast to organ transplantation, few studies correlate the monitoring of pp65 antigenemia with a diagnosis of cytomegalovirus (CMV) in patients with systemic lupus erythematosus (SLE). Objective: To highlight the importance of CMV outside transplantation, we monitored pp65 antigenemia in a series of SLE patients. Methods: From March 2015 to March 2016, SLE patients presenting kidney involvement, fever, and an unclear infection at hospital admission were monitored through pp65 antigenemia. The pp65 antigenemia assay, revealed by immunofluorescence, was correlated with clinical and laboratory findings. Results: We included 19 patients with a suspected unclear infection. A positivity for pp65 antigenemia was found in seven patients (36.8%). The mean age was 33.5 ± 11.2 years, 16 (84%) were females, and 16 (84%) were black. Lymphopenia, anemia, and higher scores of SLEDAI were significantly more common in pp65-positive patients. Five patients received antiviral therapy with ganciclovir. Although receiving specific CMV treatment, one patient died because of suspected CMV disease. Conclusions: Pp65 antigenemia might be relevant in SLE patients, and studies with a greater number of patients are needed in order to establish sensitivity and specificity of pp65 antigenemia in different clinical contexts of SLE patients.
publishDate 2018
dc.date.none.fl_str_mv 2018-03-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
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dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/2175-8239-jbn-3838
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dc.publisher.none.fl_str_mv Sociedade Brasileira de Nefrologia
publisher.none.fl_str_mv Sociedade Brasileira de Nefrologia
dc.source.none.fl_str_mv Brazilian Journal of Nephrology v.40 n.1 2018
reponame:Jornal Brasileiro de Nefrologia
instname:Sociedade Brasileira de Nefrologia (SBN)
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instname_str Sociedade Brasileira de Nefrologia (SBN)
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reponame_str Jornal Brasileiro de Nefrologia
collection Jornal Brasileiro de Nefrologia
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repository.mail.fl_str_mv ||jbn@sbn.org.br
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