Inappropriate activity of local renin-angiotensin-aldosterone system during high salt intake: impact on the cardio-renal axis

Detalhes bibliográficos
Autor(a) principal: Gonsalez,Sabrina Ribeiro
Data de Publicação: 2018
Outros Autores: Ferrão,Fernanda Magalhães, Souza,Alessandro Miranda de, Lowe,Jennifer, Morcillo,Lucienne da Silva Lara
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Jornal Brasileiro de Nefrologia
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0101-28002018000200170
Resumo: ABSTRACT Although there is a general agreement on the recommendation for reduced salt intake as a public health issue, the mechanism by which high salt intake triggers pathological effects on the cardio-renal axis is not completely understood. Emerging evidence indicates that the renin-angiotensin-aldosterone system (RAAS) is the main target of high Na+ intake. An inappropriate activation of tissue RAAS may lead to hypertension and organ damage. We reviewed the impact of high salt intake on the RAAS on the cardio-renal axis highlighting the molecular pathways that leads to injury effects. We also provide an assessment of recent observational studies related to the consequences of non-osmotically active Na+ accumulation, breaking the paradigm that high salt intake necessarily increases plasma Na+ concentration promoting water retention
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spelling Inappropriate activity of local renin-angiotensin-aldosterone system during high salt intake: impact on the cardio-renal axisReninAngiotensin IISodium, DietaryKidneyHeartABSTRACT Although there is a general agreement on the recommendation for reduced salt intake as a public health issue, the mechanism by which high salt intake triggers pathological effects on the cardio-renal axis is not completely understood. Emerging evidence indicates that the renin-angiotensin-aldosterone system (RAAS) is the main target of high Na+ intake. An inappropriate activation of tissue RAAS may lead to hypertension and organ damage. We reviewed the impact of high salt intake on the RAAS on the cardio-renal axis highlighting the molecular pathways that leads to injury effects. We also provide an assessment of recent observational studies related to the consequences of non-osmotically active Na+ accumulation, breaking the paradigm that high salt intake necessarily increases plasma Na+ concentration promoting water retentionSociedade Brasileira de Nefrologia2018-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0101-28002018000200170Brazilian Journal of Nephrology v.40 n.2 2018reponame:Jornal Brasileiro de Nefrologiainstname:Sociedade Brasileira de Nefrologia (SBN)instacron:SBN10.1590/2175-8239-jbn-3661info:eu-repo/semantics/openAccessGonsalez,Sabrina RibeiroFerrão,Fernanda MagalhãesSouza,Alessandro Miranda deLowe,JenniferMorcillo,Lucienne da Silva Laraeng2018-07-24T00:00:00Zoai:scielo:S0101-28002018000200170Revistahttp://www.bjn.org.br/ONGhttps://old.scielo.br/oai/scielo-oai.php||jbn@sbn.org.br2175-82390101-2800opendoar:2018-07-24T00:00Jornal Brasileiro de Nefrologia - Sociedade Brasileira de Nefrologia (SBN)false
dc.title.none.fl_str_mv Inappropriate activity of local renin-angiotensin-aldosterone system during high salt intake: impact on the cardio-renal axis
title Inappropriate activity of local renin-angiotensin-aldosterone system during high salt intake: impact on the cardio-renal axis
spellingShingle Inappropriate activity of local renin-angiotensin-aldosterone system during high salt intake: impact on the cardio-renal axis
Gonsalez,Sabrina Ribeiro
Renin
Angiotensin II
Sodium, Dietary
Kidney
Heart
title_short Inappropriate activity of local renin-angiotensin-aldosterone system during high salt intake: impact on the cardio-renal axis
title_full Inappropriate activity of local renin-angiotensin-aldosterone system during high salt intake: impact on the cardio-renal axis
title_fullStr Inappropriate activity of local renin-angiotensin-aldosterone system during high salt intake: impact on the cardio-renal axis
title_full_unstemmed Inappropriate activity of local renin-angiotensin-aldosterone system during high salt intake: impact on the cardio-renal axis
title_sort Inappropriate activity of local renin-angiotensin-aldosterone system during high salt intake: impact on the cardio-renal axis
author Gonsalez,Sabrina Ribeiro
author_facet Gonsalez,Sabrina Ribeiro
Ferrão,Fernanda Magalhães
Souza,Alessandro Miranda de
Lowe,Jennifer
Morcillo,Lucienne da Silva Lara
author_role author
author2 Ferrão,Fernanda Magalhães
Souza,Alessandro Miranda de
Lowe,Jennifer
Morcillo,Lucienne da Silva Lara
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Gonsalez,Sabrina Ribeiro
Ferrão,Fernanda Magalhães
Souza,Alessandro Miranda de
Lowe,Jennifer
Morcillo,Lucienne da Silva Lara
dc.subject.por.fl_str_mv Renin
Angiotensin II
Sodium, Dietary
Kidney
Heart
topic Renin
Angiotensin II
Sodium, Dietary
Kidney
Heart
description ABSTRACT Although there is a general agreement on the recommendation for reduced salt intake as a public health issue, the mechanism by which high salt intake triggers pathological effects on the cardio-renal axis is not completely understood. Emerging evidence indicates that the renin-angiotensin-aldosterone system (RAAS) is the main target of high Na+ intake. An inappropriate activation of tissue RAAS may lead to hypertension and organ damage. We reviewed the impact of high salt intake on the RAAS on the cardio-renal axis highlighting the molecular pathways that leads to injury effects. We also provide an assessment of recent observational studies related to the consequences of non-osmotically active Na+ accumulation, breaking the paradigm that high salt intake necessarily increases plasma Na+ concentration promoting water retention
publishDate 2018
dc.date.none.fl_str_mv 2018-06-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0101-28002018000200170
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0101-28002018000200170
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/2175-8239-jbn-3661
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Nefrologia
publisher.none.fl_str_mv Sociedade Brasileira de Nefrologia
dc.source.none.fl_str_mv Brazilian Journal of Nephrology v.40 n.2 2018
reponame:Jornal Brasileiro de Nefrologia
instname:Sociedade Brasileira de Nefrologia (SBN)
instacron:SBN
instname_str Sociedade Brasileira de Nefrologia (SBN)
instacron_str SBN
institution SBN
reponame_str Jornal Brasileiro de Nefrologia
collection Jornal Brasileiro de Nefrologia
repository.name.fl_str_mv Jornal Brasileiro de Nefrologia - Sociedade Brasileira de Nefrologia (SBN)
repository.mail.fl_str_mv ||jbn@sbn.org.br
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