Effect of methylprednisolone in medullar injury in rats: a functional and histological analysis

Detalhes bibliográficos
Autor(a) principal: Tebet,Marcos Antônio
Data de Publicação: 2003
Outros Autores: Barros Filho,Tarcísio Eloy Pessoa, Machado,Itibagi Rocha, Carvalho,Márcio Oliveira Penna de, Hanania,Fábio Richieri, Dací,Kuang
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Acta Ortopédica Brasileira (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-78522003000200003
Resumo: The pharmacological effects of the methylprednisolone in the treatment of the spinal cord lesion, have been researched. An experimental study was performed with twelve wistar rats subjected to a contusion lesion of the spinal cord, by the NYU system. The rats were divided in two groups; the MP group which received the methylprednisolone after the contusion lesion and the control group, which received a 0,9% physiological serum. An analysis of the recuperation of the functional movement of the rats was accomplished on the 2nd, 7th and 14th day after the contusion, utilizing the BBB test. On the fourteenth day the rats were sacrificed and the histological findings of the spinal cord lesion were analyzed. It was noted that the rats from the MP group exhibited an improvement in the recuperation of their functional movement compared to that of the control group, and the histological findings of the spinal cord lesion couldn't be correlated with the recuperation of their functional movement.
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spelling Effect of methylprednisolone in medullar injury in rats: a functional and histological analysisMethylprednisoloneSpinal cordRatsTraumatism of spinal cordMotor activityThe pharmacological effects of the methylprednisolone in the treatment of the spinal cord lesion, have been researched. An experimental study was performed with twelve wistar rats subjected to a contusion lesion of the spinal cord, by the NYU system. The rats were divided in two groups; the MP group which received the methylprednisolone after the contusion lesion and the control group, which received a 0,9% physiological serum. An analysis of the recuperation of the functional movement of the rats was accomplished on the 2nd, 7th and 14th day after the contusion, utilizing the BBB test. On the fourteenth day the rats were sacrificed and the histological findings of the spinal cord lesion were analyzed. It was noted that the rats from the MP group exhibited an improvement in the recuperation of their functional movement compared to that of the control group, and the histological findings of the spinal cord lesion couldn't be correlated with the recuperation of their functional movement.ATHA EDITORA2003-04-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-78522003000200003Acta Ortopédica Brasileira v.11 n.2 2003reponame:Acta Ortopédica Brasileira (Online)instname:Sociedade Brasileira de Ortopedia e Traumatologia (SBOT)instacron:SBOT10.1590/S1413-78522003000200003info:eu-repo/semantics/openAccessTebet,Marcos AntônioBarros Filho,Tarcísio Eloy PessoaMachado,Itibagi RochaCarvalho,Márcio Oliveira Penna deHanania,Fábio RichieriDací,Kuangeng2003-06-06T00:00:00Zoai:scielo:S1413-78522003000200003Revistahttp://www.actaortopedica.com.br/https://old.scielo.br/oai/scielo-oai.php1atha@uol.com.br||actaortopedicabrasileira@uol.com.br1809-44061413-7852opendoar:2003-06-06T00:00Acta Ortopédica Brasileira (Online) - Sociedade Brasileira de Ortopedia e Traumatologia (SBOT)false
dc.title.none.fl_str_mv Effect of methylprednisolone in medullar injury in rats: a functional and histological analysis
title Effect of methylprednisolone in medullar injury in rats: a functional and histological analysis
spellingShingle Effect of methylprednisolone in medullar injury in rats: a functional and histological analysis
Tebet,Marcos Antônio
Methylprednisolone
Spinal cord
Rats
Traumatism of spinal cord
Motor activity
title_short Effect of methylprednisolone in medullar injury in rats: a functional and histological analysis
title_full Effect of methylprednisolone in medullar injury in rats: a functional and histological analysis
title_fullStr Effect of methylprednisolone in medullar injury in rats: a functional and histological analysis
title_full_unstemmed Effect of methylprednisolone in medullar injury in rats: a functional and histological analysis
title_sort Effect of methylprednisolone in medullar injury in rats: a functional and histological analysis
author Tebet,Marcos Antônio
author_facet Tebet,Marcos Antônio
Barros Filho,Tarcísio Eloy Pessoa
Machado,Itibagi Rocha
Carvalho,Márcio Oliveira Penna de
Hanania,Fábio Richieri
Dací,Kuang
author_role author
author2 Barros Filho,Tarcísio Eloy Pessoa
Machado,Itibagi Rocha
Carvalho,Márcio Oliveira Penna de
Hanania,Fábio Richieri
Dací,Kuang
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Tebet,Marcos Antônio
Barros Filho,Tarcísio Eloy Pessoa
Machado,Itibagi Rocha
Carvalho,Márcio Oliveira Penna de
Hanania,Fábio Richieri
Dací,Kuang
dc.subject.por.fl_str_mv Methylprednisolone
Spinal cord
Rats
Traumatism of spinal cord
Motor activity
topic Methylprednisolone
Spinal cord
Rats
Traumatism of spinal cord
Motor activity
description The pharmacological effects of the methylprednisolone in the treatment of the spinal cord lesion, have been researched. An experimental study was performed with twelve wistar rats subjected to a contusion lesion of the spinal cord, by the NYU system. The rats were divided in two groups; the MP group which received the methylprednisolone after the contusion lesion and the control group, which received a 0,9% physiological serum. An analysis of the recuperation of the functional movement of the rats was accomplished on the 2nd, 7th and 14th day after the contusion, utilizing the BBB test. On the fourteenth day the rats were sacrificed and the histological findings of the spinal cord lesion were analyzed. It was noted that the rats from the MP group exhibited an improvement in the recuperation of their functional movement compared to that of the control group, and the histological findings of the spinal cord lesion couldn't be correlated with the recuperation of their functional movement.
publishDate 2003
dc.date.none.fl_str_mv 2003-04-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
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dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-78522003000200003
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-78522003000200003
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S1413-78522003000200003
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv ATHA EDITORA
publisher.none.fl_str_mv ATHA EDITORA
dc.source.none.fl_str_mv Acta Ortopédica Brasileira v.11 n.2 2003
reponame:Acta Ortopédica Brasileira (Online)
instname:Sociedade Brasileira de Ortopedia e Traumatologia (SBOT)
instacron:SBOT
instname_str Sociedade Brasileira de Ortopedia e Traumatologia (SBOT)
instacron_str SBOT
institution SBOT
reponame_str Acta Ortopédica Brasileira (Online)
collection Acta Ortopédica Brasileira (Online)
repository.name.fl_str_mv Acta Ortopédica Brasileira (Online) - Sociedade Brasileira de Ortopedia e Traumatologia (SBOT)
repository.mail.fl_str_mv 1atha@uol.com.br||actaortopedicabrasileira@uol.com.br
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