Effects of methylprednisolone and ganglioside GM-1 on a spinal lesion: a functional analysis
Autor(a) principal: | |
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Data de Publicação: | 2008 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Clinics |
Texto Completo: | https://www.revistas.usp.br/clinics/article/view/17809 |
Resumo: | OBJECTIVES: The pharmacological effects of methylprednisolone (MP) and ganglioside GM-1 on spinal injuries have been thoroughly investigated, but only a few studies have evaluated the interaction between these two drugs. METHODS: Twenty-four Wistar rats were subjected to contusive injury of the spinal cord produced by the NYU system. These animals were divided into four groups: group I was injected with MP; group II was injected with GM-1; group III was injected with MP together with GM-1; and group control received physiological serum. The animals were evaluated with regard to their recovery of locomotive function by means of the BBB test on the second, seventh and fourteenth days after receiving the contusive injury to the spinal cord. They were sacrificed on the fourteenth day. RESULTS: This study demonstrated that the MP and GM-1 groups presented functional results that were better than those of the control group, although the enhanced recovery of group II (GM-1) relative to the control group was not statistically significant (p>;0.05). The most notable recovery of locomotive function was observed in the group that received MP alone (p |
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Clinics |
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Effects of methylprednisolone and ganglioside GM-1 on a spinal lesion: a functional analysis MethylprednisoloneGanglioside GM-1Spinal cordWistar ratsMotor activity OBJECTIVES: The pharmacological effects of methylprednisolone (MP) and ganglioside GM-1 on spinal injuries have been thoroughly investigated, but only a few studies have evaluated the interaction between these two drugs. METHODS: Twenty-four Wistar rats were subjected to contusive injury of the spinal cord produced by the NYU system. These animals were divided into four groups: group I was injected with MP; group II was injected with GM-1; group III was injected with MP together with GM-1; and group control received physiological serum. The animals were evaluated with regard to their recovery of locomotive function by means of the BBB test on the second, seventh and fourteenth days after receiving the contusive injury to the spinal cord. They were sacrificed on the fourteenth day. RESULTS: This study demonstrated that the MP and GM-1 groups presented functional results that were better than those of the control group, although the enhanced recovery of group II (GM-1) relative to the control group was not statistically significant (p>;0.05). The most notable recovery of locomotive function was observed in the group that received MP alone (pHospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo2008-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/clinics/article/view/1780910.1590/S1807-59322008000300015Clinics; Vol. 63 No. 3 (2008); 375-380 Clinics; v. 63 n. 3 (2008); 375-380 Clinics; Vol. 63 Núm. 3 (2008); 375-380 1980-53221807-5932reponame:Clinicsinstname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/clinics/article/view/17809/19874Carvalho, Márcio Oliveira PennaBarros Filho, Tarcisio Eloy Pessoa deTebet, Marcos Antonioinfo:eu-repo/semantics/openAccess2012-05-22T18:35:16Zoai:revistas.usp.br:article/17809Revistahttps://www.revistas.usp.br/clinicsPUBhttps://www.revistas.usp.br/clinics/oai||clinics@hc.fm.usp.br1980-53221807-5932opendoar:2012-05-22T18:35:16Clinics - Universidade de São Paulo (USP)false |
dc.title.none.fl_str_mv |
Effects of methylprednisolone and ganglioside GM-1 on a spinal lesion: a functional analysis |
title |
Effects of methylprednisolone and ganglioside GM-1 on a spinal lesion: a functional analysis |
spellingShingle |
Effects of methylprednisolone and ganglioside GM-1 on a spinal lesion: a functional analysis Carvalho, Márcio Oliveira Penna Methylprednisolone Ganglioside GM-1 Spinal cord Wistar rats Motor activity |
title_short |
Effects of methylprednisolone and ganglioside GM-1 on a spinal lesion: a functional analysis |
title_full |
Effects of methylprednisolone and ganglioside GM-1 on a spinal lesion: a functional analysis |
title_fullStr |
Effects of methylprednisolone and ganglioside GM-1 on a spinal lesion: a functional analysis |
title_full_unstemmed |
Effects of methylprednisolone and ganglioside GM-1 on a spinal lesion: a functional analysis |
title_sort |
Effects of methylprednisolone and ganglioside GM-1 on a spinal lesion: a functional analysis |
author |
Carvalho, Márcio Oliveira Penna |
author_facet |
Carvalho, Márcio Oliveira Penna Barros Filho, Tarcisio Eloy Pessoa de Tebet, Marcos Antonio |
author_role |
author |
author2 |
Barros Filho, Tarcisio Eloy Pessoa de Tebet, Marcos Antonio |
author2_role |
author author |
dc.contributor.author.fl_str_mv |
Carvalho, Márcio Oliveira Penna Barros Filho, Tarcisio Eloy Pessoa de Tebet, Marcos Antonio |
dc.subject.por.fl_str_mv |
Methylprednisolone Ganglioside GM-1 Spinal cord Wistar rats Motor activity |
topic |
Methylprednisolone Ganglioside GM-1 Spinal cord Wistar rats Motor activity |
description |
OBJECTIVES: The pharmacological effects of methylprednisolone (MP) and ganglioside GM-1 on spinal injuries have been thoroughly investigated, but only a few studies have evaluated the interaction between these two drugs. METHODS: Twenty-four Wistar rats were subjected to contusive injury of the spinal cord produced by the NYU system. These animals were divided into four groups: group I was injected with MP; group II was injected with GM-1; group III was injected with MP together with GM-1; and group control received physiological serum. The animals were evaluated with regard to their recovery of locomotive function by means of the BBB test on the second, seventh and fourteenth days after receiving the contusive injury to the spinal cord. They were sacrificed on the fourteenth day. RESULTS: This study demonstrated that the MP and GM-1 groups presented functional results that were better than those of the control group, although the enhanced recovery of group II (GM-1) relative to the control group was not statistically significant (p>;0.05). The most notable recovery of locomotive function was observed in the group that received MP alone (p |
publishDate |
2008 |
dc.date.none.fl_str_mv |
2008-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.revistas.usp.br/clinics/article/view/17809 10.1590/S1807-59322008000300015 |
url |
https://www.revistas.usp.br/clinics/article/view/17809 |
identifier_str_mv |
10.1590/S1807-59322008000300015 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://www.revistas.usp.br/clinics/article/view/17809/19874 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo |
publisher.none.fl_str_mv |
Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo |
dc.source.none.fl_str_mv |
Clinics; Vol. 63 No. 3 (2008); 375-380 Clinics; v. 63 n. 3 (2008); 375-380 Clinics; Vol. 63 Núm. 3 (2008); 375-380 1980-5322 1807-5932 reponame:Clinics instname:Universidade de São Paulo (USP) instacron:USP |
instname_str |
Universidade de São Paulo (USP) |
instacron_str |
USP |
institution |
USP |
reponame_str |
Clinics |
collection |
Clinics |
repository.name.fl_str_mv |
Clinics - Universidade de São Paulo (USP) |
repository.mail.fl_str_mv |
||clinics@hc.fm.usp.br |
_version_ |
1800222753907802112 |