Effects of methylprednisolone and ganglioside GM-1 on a spinal lesion: a functional analysis

Detalhes bibliográficos
Autor(a) principal: Carvalho, Márcio Oliveira Penna
Data de Publicação: 2008
Outros Autores: Barros Filho, Tarcisio Eloy Pessoa de, Tebet, Marcos Antonio
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Clinics
Texto Completo: https://www.revistas.usp.br/clinics/article/view/17809
Resumo: OBJECTIVES: The pharmacological effects of methylprednisolone (MP) and ganglioside GM-1 on spinal injuries have been thoroughly investigated, but only a few studies have evaluated the interaction between these two drugs. METHODS: Twenty-four Wistar rats were subjected to contusive injury of the spinal cord produced by the NYU system. These animals were divided into four groups: group I was injected with MP; group II was injected with GM-1; group III was injected with MP together with GM-1; and group control received physiological serum. The animals were evaluated with regard to their recovery of locomotive function by means of the BBB test on the second, seventh and fourteenth days after receiving the contusive injury to the spinal cord. They were sacrificed on the fourteenth day. RESULTS: This study demonstrated that the MP and GM-1 groups presented functional results that were better than those of the control group, although the enhanced recovery of group II (GM-1) relative to the control group was not statistically significant (p>;0.05). The most notable recovery of locomotive function was observed in the group that received MP alone (p
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spelling Effects of methylprednisolone and ganglioside GM-1 on a spinal lesion: a functional analysis MethylprednisoloneGanglioside GM-1Spinal cordWistar ratsMotor activity OBJECTIVES: The pharmacological effects of methylprednisolone (MP) and ganglioside GM-1 on spinal injuries have been thoroughly investigated, but only a few studies have evaluated the interaction between these two drugs. METHODS: Twenty-four Wistar rats were subjected to contusive injury of the spinal cord produced by the NYU system. These animals were divided into four groups: group I was injected with MP; group II was injected with GM-1; group III was injected with MP together with GM-1; and group control received physiological serum. The animals were evaluated with regard to their recovery of locomotive function by means of the BBB test on the second, seventh and fourteenth days after receiving the contusive injury to the spinal cord. They were sacrificed on the fourteenth day. RESULTS: This study demonstrated that the MP and GM-1 groups presented functional results that were better than those of the control group, although the enhanced recovery of group II (GM-1) relative to the control group was not statistically significant (p>;0.05). The most notable recovery of locomotive function was observed in the group that received MP alone (pHospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo2008-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/clinics/article/view/1780910.1590/S1807-59322008000300015Clinics; Vol. 63 No. 3 (2008); 375-380 Clinics; v. 63 n. 3 (2008); 375-380 Clinics; Vol. 63 Núm. 3 (2008); 375-380 1980-53221807-5932reponame:Clinicsinstname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/clinics/article/view/17809/19874Carvalho, Márcio Oliveira PennaBarros Filho, Tarcisio Eloy Pessoa deTebet, Marcos Antonioinfo:eu-repo/semantics/openAccess2012-05-22T18:35:16Zoai:revistas.usp.br:article/17809Revistahttps://www.revistas.usp.br/clinicsPUBhttps://www.revistas.usp.br/clinics/oai||clinics@hc.fm.usp.br1980-53221807-5932opendoar:2012-05-22T18:35:16Clinics - Universidade de São Paulo (USP)false
dc.title.none.fl_str_mv Effects of methylprednisolone and ganglioside GM-1 on a spinal lesion: a functional analysis
title Effects of methylprednisolone and ganglioside GM-1 on a spinal lesion: a functional analysis
spellingShingle Effects of methylprednisolone and ganglioside GM-1 on a spinal lesion: a functional analysis
Carvalho, Márcio Oliveira Penna
Methylprednisolone
Ganglioside GM-1
Spinal cord
Wistar rats
Motor activity
title_short Effects of methylprednisolone and ganglioside GM-1 on a spinal lesion: a functional analysis
title_full Effects of methylprednisolone and ganglioside GM-1 on a spinal lesion: a functional analysis
title_fullStr Effects of methylprednisolone and ganglioside GM-1 on a spinal lesion: a functional analysis
title_full_unstemmed Effects of methylprednisolone and ganglioside GM-1 on a spinal lesion: a functional analysis
title_sort Effects of methylprednisolone and ganglioside GM-1 on a spinal lesion: a functional analysis
author Carvalho, Márcio Oliveira Penna
author_facet Carvalho, Márcio Oliveira Penna
Barros Filho, Tarcisio Eloy Pessoa de
Tebet, Marcos Antonio
author_role author
author2 Barros Filho, Tarcisio Eloy Pessoa de
Tebet, Marcos Antonio
author2_role author
author
dc.contributor.author.fl_str_mv Carvalho, Márcio Oliveira Penna
Barros Filho, Tarcisio Eloy Pessoa de
Tebet, Marcos Antonio
dc.subject.por.fl_str_mv Methylprednisolone
Ganglioside GM-1
Spinal cord
Wistar rats
Motor activity
topic Methylprednisolone
Ganglioside GM-1
Spinal cord
Wistar rats
Motor activity
description OBJECTIVES: The pharmacological effects of methylprednisolone (MP) and ganglioside GM-1 on spinal injuries have been thoroughly investigated, but only a few studies have evaluated the interaction between these two drugs. METHODS: Twenty-four Wistar rats were subjected to contusive injury of the spinal cord produced by the NYU system. These animals were divided into four groups: group I was injected with MP; group II was injected with GM-1; group III was injected with MP together with GM-1; and group control received physiological serum. The animals were evaluated with regard to their recovery of locomotive function by means of the BBB test on the second, seventh and fourteenth days after receiving the contusive injury to the spinal cord. They were sacrificed on the fourteenth day. RESULTS: This study demonstrated that the MP and GM-1 groups presented functional results that were better than those of the control group, although the enhanced recovery of group II (GM-1) relative to the control group was not statistically significant (p>;0.05). The most notable recovery of locomotive function was observed in the group that received MP alone (p
publishDate 2008
dc.date.none.fl_str_mv 2008-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://www.revistas.usp.br/clinics/article/view/17809
10.1590/S1807-59322008000300015
url https://www.revistas.usp.br/clinics/article/view/17809
identifier_str_mv 10.1590/S1807-59322008000300015
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://www.revistas.usp.br/clinics/article/view/17809/19874
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo
publisher.none.fl_str_mv Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo
dc.source.none.fl_str_mv Clinics; Vol. 63 No. 3 (2008); 375-380
Clinics; v. 63 n. 3 (2008); 375-380
Clinics; Vol. 63 Núm. 3 (2008); 375-380
1980-5322
1807-5932
reponame:Clinics
instname:Universidade de São Paulo (USP)
instacron:USP
instname_str Universidade de São Paulo (USP)
instacron_str USP
institution USP
reponame_str Clinics
collection Clinics
repository.name.fl_str_mv Clinics - Universidade de São Paulo (USP)
repository.mail.fl_str_mv ||clinics@hc.fm.usp.br
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