RANDOMIZED CONTROLLED TRIAL OF LIMITED FASCIECTOMY WITH INJECTION OF ADIPOSE GRAFT FOR DUPUYTREN’S DISEASE

Detalhes bibliográficos
Autor(a) principal: Sambuy,Marina Tommasini C.
Data de Publicação: 2020
Outros Autores: Nakamoto,Hugo A., Bolliger Neto,Raul, Mattar Jr.,Rames, Rezende,Marcelo R., Wei,Teng Hsiang
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Acta Ortopédica Brasileira (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-78522020000400159
Resumo: ABSTRACT Objective: Dupuytren’s disease is a genetic disorder related to the proliferation of myofibroblasts. The pluripotent property of stem cells present in adipose tissue inhibits myofibroblast proliferation. Our study sought to evaluate the effect of stem cell-rich fat grafts in patients that underwent limited fasciectomy. Methods: We studied 45 patients, in a single-blind, prospective, randomized clinical trial. All patients underwent limited fasciectomy. In one group, fat graft was injected. Results: The total passive extension deficit results did not exhibit a significant difference. Fat group exhibited worse functional score at 6 months and 1 year postoperatively, such as higher complication rates (43%), when compared with control group (8%), and more pain at 6 weeks follow-up. Conclusion: Fat grafting associated with limited fasciectomy promotes worse functional results compared to conventional limited fasciectomy in the short term. However, long-term results and recurrence rates should be further assessed. Level of Evidence II, Prospective comparative study.
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spelling RANDOMIZED CONTROLLED TRIAL OF LIMITED FASCIECTOMY WITH INJECTION OF ADIPOSE GRAFT FOR DUPUYTREN’S DISEASEDupuytren ContractureAdipose TissueFasciectomyStem CellsRandomized Controlled TrialClinical TrialABSTRACT Objective: Dupuytren’s disease is a genetic disorder related to the proliferation of myofibroblasts. The pluripotent property of stem cells present in adipose tissue inhibits myofibroblast proliferation. Our study sought to evaluate the effect of stem cell-rich fat grafts in patients that underwent limited fasciectomy. Methods: We studied 45 patients, in a single-blind, prospective, randomized clinical trial. All patients underwent limited fasciectomy. In one group, fat graft was injected. Results: The total passive extension deficit results did not exhibit a significant difference. Fat group exhibited worse functional score at 6 months and 1 year postoperatively, such as higher complication rates (43%), when compared with control group (8%), and more pain at 6 weeks follow-up. Conclusion: Fat grafting associated with limited fasciectomy promotes worse functional results compared to conventional limited fasciectomy in the short term. However, long-term results and recurrence rates should be further assessed. Level of Evidence II, Prospective comparative study.ATHA EDITORA2020-08-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-78522020000400159Acta Ortopédica Brasileira v.28 n.4 2020reponame:Acta Ortopédica Brasileira (Online)instname:Sociedade Brasileira de Ortopedia e Traumatologia (SBOT)instacron:SBOT10.1590/1413-785220202804233522info:eu-repo/semantics/openAccessSambuy,Marina Tommasini C.Nakamoto,Hugo A.Bolliger Neto,RaulMattar Jr.,RamesRezende,Marcelo R.Wei,Teng Hsiangeng2020-10-14T00:00:00Zoai:scielo:S1413-78522020000400159Revistahttp://www.actaortopedica.com.br/https://old.scielo.br/oai/scielo-oai.php1atha@uol.com.br||actaortopedicabrasileira@uol.com.br1809-44061413-7852opendoar:2020-10-14T00:00Acta Ortopédica Brasileira (Online) - Sociedade Brasileira de Ortopedia e Traumatologia (SBOT)false
dc.title.none.fl_str_mv RANDOMIZED CONTROLLED TRIAL OF LIMITED FASCIECTOMY WITH INJECTION OF ADIPOSE GRAFT FOR DUPUYTREN’S DISEASE
title RANDOMIZED CONTROLLED TRIAL OF LIMITED FASCIECTOMY WITH INJECTION OF ADIPOSE GRAFT FOR DUPUYTREN’S DISEASE
spellingShingle RANDOMIZED CONTROLLED TRIAL OF LIMITED FASCIECTOMY WITH INJECTION OF ADIPOSE GRAFT FOR DUPUYTREN’S DISEASE
Sambuy,Marina Tommasini C.
Dupuytren Contracture
Adipose Tissue
Fasciectomy
Stem Cells
Randomized Controlled Trial
Clinical Trial
title_short RANDOMIZED CONTROLLED TRIAL OF LIMITED FASCIECTOMY WITH INJECTION OF ADIPOSE GRAFT FOR DUPUYTREN’S DISEASE
title_full RANDOMIZED CONTROLLED TRIAL OF LIMITED FASCIECTOMY WITH INJECTION OF ADIPOSE GRAFT FOR DUPUYTREN’S DISEASE
title_fullStr RANDOMIZED CONTROLLED TRIAL OF LIMITED FASCIECTOMY WITH INJECTION OF ADIPOSE GRAFT FOR DUPUYTREN’S DISEASE
title_full_unstemmed RANDOMIZED CONTROLLED TRIAL OF LIMITED FASCIECTOMY WITH INJECTION OF ADIPOSE GRAFT FOR DUPUYTREN’S DISEASE
title_sort RANDOMIZED CONTROLLED TRIAL OF LIMITED FASCIECTOMY WITH INJECTION OF ADIPOSE GRAFT FOR DUPUYTREN’S DISEASE
author Sambuy,Marina Tommasini C.
author_facet Sambuy,Marina Tommasini C.
Nakamoto,Hugo A.
Bolliger Neto,Raul
Mattar Jr.,Rames
Rezende,Marcelo R.
Wei,Teng Hsiang
author_role author
author2 Nakamoto,Hugo A.
Bolliger Neto,Raul
Mattar Jr.,Rames
Rezende,Marcelo R.
Wei,Teng Hsiang
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Sambuy,Marina Tommasini C.
Nakamoto,Hugo A.
Bolliger Neto,Raul
Mattar Jr.,Rames
Rezende,Marcelo R.
Wei,Teng Hsiang
dc.subject.por.fl_str_mv Dupuytren Contracture
Adipose Tissue
Fasciectomy
Stem Cells
Randomized Controlled Trial
Clinical Trial
topic Dupuytren Contracture
Adipose Tissue
Fasciectomy
Stem Cells
Randomized Controlled Trial
Clinical Trial
description ABSTRACT Objective: Dupuytren’s disease is a genetic disorder related to the proliferation of myofibroblasts. The pluripotent property of stem cells present in adipose tissue inhibits myofibroblast proliferation. Our study sought to evaluate the effect of stem cell-rich fat grafts in patients that underwent limited fasciectomy. Methods: We studied 45 patients, in a single-blind, prospective, randomized clinical trial. All patients underwent limited fasciectomy. In one group, fat graft was injected. Results: The total passive extension deficit results did not exhibit a significant difference. Fat group exhibited worse functional score at 6 months and 1 year postoperatively, such as higher complication rates (43%), when compared with control group (8%), and more pain at 6 weeks follow-up. Conclusion: Fat grafting associated with limited fasciectomy promotes worse functional results compared to conventional limited fasciectomy in the short term. However, long-term results and recurrence rates should be further assessed. Level of Evidence II, Prospective comparative study.
publishDate 2020
dc.date.none.fl_str_mv 2020-08-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
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dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-78522020000400159
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-78522020000400159
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/1413-785220202804233522
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv ATHA EDITORA
publisher.none.fl_str_mv ATHA EDITORA
dc.source.none.fl_str_mv Acta Ortopédica Brasileira v.28 n.4 2020
reponame:Acta Ortopédica Brasileira (Online)
instname:Sociedade Brasileira de Ortopedia e Traumatologia (SBOT)
instacron:SBOT
instname_str Sociedade Brasileira de Ortopedia e Traumatologia (SBOT)
instacron_str SBOT
institution SBOT
reponame_str Acta Ortopédica Brasileira (Online)
collection Acta Ortopédica Brasileira (Online)
repository.name.fl_str_mv Acta Ortopédica Brasileira (Online) - Sociedade Brasileira de Ortopedia e Traumatologia (SBOT)
repository.mail.fl_str_mv 1atha@uol.com.br||actaortopedicabrasileira@uol.com.br
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