Evaluation of the use of tranexamic acid in total knee arthroplasty

Detalhes bibliográficos
Autor(a) principal: Almeida,Mariana Diana Chaves de
Data de Publicação: 2018
Outros Autores: Albuquerque,Rodrigo Pires e, Palhares,Guilherme Mathias, Almeida,Juliana Patrícia Chaves de, Barretto,João Mauricio, Cavanellas,Naasson
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Revista Brasileira de Ortopedia (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-36162018000600761
Resumo: ABSTRACT Objective: Evaluate the efficacy of tranexamic acid in reducing bleeding in patients undergoing total knee arthroplasty. Methods: 101 patients were randomized into two groups: the tranexamic acid group (n = 51) and the placebo group (n = 50). Patients were compared regarding the following parameters: reduction of hemoglobin, total estimated blood loss, drain output, and postoperative blood transfusion rate. Results: Comparing the groups, there were statistically significant differences (p < 0.05) in the following parameters: reduction of hemoglobin, decreased hematocrit, estimated blood loss, and drain output. All values were lower in the tranexamic acid group. Only placebo group patients required blood transfusion. Conclusion: The use of intravenous tranexamic acid is effective to reduce bleeding in patients undergoing total knee arthroplasty.
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spelling Evaluation of the use of tranexamic acid in total knee arthroplastyTranexamic acidBleedingOrthopedicTotal knee arthroplastyBlood transfusionBlood volumeABSTRACT Objective: Evaluate the efficacy of tranexamic acid in reducing bleeding in patients undergoing total knee arthroplasty. Methods: 101 patients were randomized into two groups: the tranexamic acid group (n = 51) and the placebo group (n = 50). Patients were compared regarding the following parameters: reduction of hemoglobin, total estimated blood loss, drain output, and postoperative blood transfusion rate. Results: Comparing the groups, there were statistically significant differences (p < 0.05) in the following parameters: reduction of hemoglobin, decreased hematocrit, estimated blood loss, and drain output. All values were lower in the tranexamic acid group. Only placebo group patients required blood transfusion. Conclusion: The use of intravenous tranexamic acid is effective to reduce bleeding in patients undergoing total knee arthroplasty.Sociedade Brasileira de Ortopedia e Traumatologia2018-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-36162018000600761Revista Brasileira de Ortopedia v.53 n.6 2018reponame:Revista Brasileira de Ortopedia (Online)instname:Sociedade Brasileira de Ortopedia e Traumatologia (SBOT)instacron:SBOT10.1016/j.rboe.2018.09.008info:eu-repo/semantics/openAccessAlmeida,Mariana Diana Chaves deAlbuquerque,Rodrigo Pires ePalhares,Guilherme MathiasAlmeida,Juliana Patrícia Chaves deBarretto,João MauricioCavanellas,Naassoneng2018-11-29T00:00:00Zoai:scielo:S0102-36162018000600761Revistahttp://www.rbo.org.br/https://old.scielo.br/oai/scielo-oai.php||rbo@sbot.org.br1982-43780102-3616opendoar:2018-11-29T00:00Revista Brasileira de Ortopedia (Online) - Sociedade Brasileira de Ortopedia e Traumatologia (SBOT)false
dc.title.none.fl_str_mv Evaluation of the use of tranexamic acid in total knee arthroplasty
title Evaluation of the use of tranexamic acid in total knee arthroplasty
spellingShingle Evaluation of the use of tranexamic acid in total knee arthroplasty
Almeida,Mariana Diana Chaves de
Tranexamic acid
Bleeding
Orthopedic
Total knee arthroplasty
Blood transfusion
Blood volume
title_short Evaluation of the use of tranexamic acid in total knee arthroplasty
title_full Evaluation of the use of tranexamic acid in total knee arthroplasty
title_fullStr Evaluation of the use of tranexamic acid in total knee arthroplasty
title_full_unstemmed Evaluation of the use of tranexamic acid in total knee arthroplasty
title_sort Evaluation of the use of tranexamic acid in total knee arthroplasty
author Almeida,Mariana Diana Chaves de
author_facet Almeida,Mariana Diana Chaves de
Albuquerque,Rodrigo Pires e
Palhares,Guilherme Mathias
Almeida,Juliana Patrícia Chaves de
Barretto,João Mauricio
Cavanellas,Naasson
author_role author
author2 Albuquerque,Rodrigo Pires e
Palhares,Guilherme Mathias
Almeida,Juliana Patrícia Chaves de
Barretto,João Mauricio
Cavanellas,Naasson
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Almeida,Mariana Diana Chaves de
Albuquerque,Rodrigo Pires e
Palhares,Guilherme Mathias
Almeida,Juliana Patrícia Chaves de
Barretto,João Mauricio
Cavanellas,Naasson
dc.subject.por.fl_str_mv Tranexamic acid
Bleeding
Orthopedic
Total knee arthroplasty
Blood transfusion
Blood volume
topic Tranexamic acid
Bleeding
Orthopedic
Total knee arthroplasty
Blood transfusion
Blood volume
description ABSTRACT Objective: Evaluate the efficacy of tranexamic acid in reducing bleeding in patients undergoing total knee arthroplasty. Methods: 101 patients were randomized into two groups: the tranexamic acid group (n = 51) and the placebo group (n = 50). Patients were compared regarding the following parameters: reduction of hemoglobin, total estimated blood loss, drain output, and postoperative blood transfusion rate. Results: Comparing the groups, there were statistically significant differences (p < 0.05) in the following parameters: reduction of hemoglobin, decreased hematocrit, estimated blood loss, and drain output. All values were lower in the tranexamic acid group. Only placebo group patients required blood transfusion. Conclusion: The use of intravenous tranexamic acid is effective to reduce bleeding in patients undergoing total knee arthroplasty.
publishDate 2018
dc.date.none.fl_str_mv 2018-12-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-36162018000600761
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-36162018000600761
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1016/j.rboe.2018.09.008
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Ortopedia e Traumatologia
publisher.none.fl_str_mv Sociedade Brasileira de Ortopedia e Traumatologia
dc.source.none.fl_str_mv Revista Brasileira de Ortopedia v.53 n.6 2018
reponame:Revista Brasileira de Ortopedia (Online)
instname:Sociedade Brasileira de Ortopedia e Traumatologia (SBOT)
instacron:SBOT
instname_str Sociedade Brasileira de Ortopedia e Traumatologia (SBOT)
instacron_str SBOT
institution SBOT
reponame_str Revista Brasileira de Ortopedia (Online)
collection Revista Brasileira de Ortopedia (Online)
repository.name.fl_str_mv Revista Brasileira de Ortopedia (Online) - Sociedade Brasileira de Ortopedia e Traumatologia (SBOT)
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