Evaluation of the use of tranexamic acid in total knee arthroplasty
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Revista Brasileira de Ortopedia (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-36162018000600761 |
Resumo: | ABSTRACT Objective: Evaluate the efficacy of tranexamic acid in reducing bleeding in patients undergoing total knee arthroplasty. Methods: 101 patients were randomized into two groups: the tranexamic acid group (n = 51) and the placebo group (n = 50). Patients were compared regarding the following parameters: reduction of hemoglobin, total estimated blood loss, drain output, and postoperative blood transfusion rate. Results: Comparing the groups, there were statistically significant differences (p < 0.05) in the following parameters: reduction of hemoglobin, decreased hematocrit, estimated blood loss, and drain output. All values were lower in the tranexamic acid group. Only placebo group patients required blood transfusion. Conclusion: The use of intravenous tranexamic acid is effective to reduce bleeding in patients undergoing total knee arthroplasty. |
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Revista Brasileira de Ortopedia (Online) |
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Evaluation of the use of tranexamic acid in total knee arthroplastyTranexamic acidBleedingOrthopedicTotal knee arthroplastyBlood transfusionBlood volumeABSTRACT Objective: Evaluate the efficacy of tranexamic acid in reducing bleeding in patients undergoing total knee arthroplasty. Methods: 101 patients were randomized into two groups: the tranexamic acid group (n = 51) and the placebo group (n = 50). Patients were compared regarding the following parameters: reduction of hemoglobin, total estimated blood loss, drain output, and postoperative blood transfusion rate. Results: Comparing the groups, there were statistically significant differences (p < 0.05) in the following parameters: reduction of hemoglobin, decreased hematocrit, estimated blood loss, and drain output. All values were lower in the tranexamic acid group. Only placebo group patients required blood transfusion. Conclusion: The use of intravenous tranexamic acid is effective to reduce bleeding in patients undergoing total knee arthroplasty.Sociedade Brasileira de Ortopedia e Traumatologia2018-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-36162018000600761Revista Brasileira de Ortopedia v.53 n.6 2018reponame:Revista Brasileira de Ortopedia (Online)instname:Sociedade Brasileira de Ortopedia e Traumatologia (SBOT)instacron:SBOT10.1016/j.rboe.2018.09.008info:eu-repo/semantics/openAccessAlmeida,Mariana Diana Chaves deAlbuquerque,Rodrigo Pires ePalhares,Guilherme MathiasAlmeida,Juliana Patrícia Chaves deBarretto,João MauricioCavanellas,Naassoneng2018-11-29T00:00:00Zoai:scielo:S0102-36162018000600761Revistahttp://www.rbo.org.br/https://old.scielo.br/oai/scielo-oai.php||rbo@sbot.org.br1982-43780102-3616opendoar:2018-11-29T00:00Revista Brasileira de Ortopedia (Online) - Sociedade Brasileira de Ortopedia e Traumatologia (SBOT)false |
dc.title.none.fl_str_mv |
Evaluation of the use of tranexamic acid in total knee arthroplasty |
title |
Evaluation of the use of tranexamic acid in total knee arthroplasty |
spellingShingle |
Evaluation of the use of tranexamic acid in total knee arthroplasty Almeida,Mariana Diana Chaves de Tranexamic acid Bleeding Orthopedic Total knee arthroplasty Blood transfusion Blood volume |
title_short |
Evaluation of the use of tranexamic acid in total knee arthroplasty |
title_full |
Evaluation of the use of tranexamic acid in total knee arthroplasty |
title_fullStr |
Evaluation of the use of tranexamic acid in total knee arthroplasty |
title_full_unstemmed |
Evaluation of the use of tranexamic acid in total knee arthroplasty |
title_sort |
Evaluation of the use of tranexamic acid in total knee arthroplasty |
author |
Almeida,Mariana Diana Chaves de |
author_facet |
Almeida,Mariana Diana Chaves de Albuquerque,Rodrigo Pires e Palhares,Guilherme Mathias Almeida,Juliana Patrícia Chaves de Barretto,João Mauricio Cavanellas,Naasson |
author_role |
author |
author2 |
Albuquerque,Rodrigo Pires e Palhares,Guilherme Mathias Almeida,Juliana Patrícia Chaves de Barretto,João Mauricio Cavanellas,Naasson |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Almeida,Mariana Diana Chaves de Albuquerque,Rodrigo Pires e Palhares,Guilherme Mathias Almeida,Juliana Patrícia Chaves de Barretto,João Mauricio Cavanellas,Naasson |
dc.subject.por.fl_str_mv |
Tranexamic acid Bleeding Orthopedic Total knee arthroplasty Blood transfusion Blood volume |
topic |
Tranexamic acid Bleeding Orthopedic Total knee arthroplasty Blood transfusion Blood volume |
description |
ABSTRACT Objective: Evaluate the efficacy of tranexamic acid in reducing bleeding in patients undergoing total knee arthroplasty. Methods: 101 patients were randomized into two groups: the tranexamic acid group (n = 51) and the placebo group (n = 50). Patients were compared regarding the following parameters: reduction of hemoglobin, total estimated blood loss, drain output, and postoperative blood transfusion rate. Results: Comparing the groups, there were statistically significant differences (p < 0.05) in the following parameters: reduction of hemoglobin, decreased hematocrit, estimated blood loss, and drain output. All values were lower in the tranexamic acid group. Only placebo group patients required blood transfusion. Conclusion: The use of intravenous tranexamic acid is effective to reduce bleeding in patients undergoing total knee arthroplasty. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-12-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-36162018000600761 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-36162018000600761 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1016/j.rboe.2018.09.008 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Ortopedia e Traumatologia |
publisher.none.fl_str_mv |
Sociedade Brasileira de Ortopedia e Traumatologia |
dc.source.none.fl_str_mv |
Revista Brasileira de Ortopedia v.53 n.6 2018 reponame:Revista Brasileira de Ortopedia (Online) instname:Sociedade Brasileira de Ortopedia e Traumatologia (SBOT) instacron:SBOT |
instname_str |
Sociedade Brasileira de Ortopedia e Traumatologia (SBOT) |
instacron_str |
SBOT |
institution |
SBOT |
reponame_str |
Revista Brasileira de Ortopedia (Online) |
collection |
Revista Brasileira de Ortopedia (Online) |
repository.name.fl_str_mv |
Revista Brasileira de Ortopedia (Online) - Sociedade Brasileira de Ortopedia e Traumatologia (SBOT) |
repository.mail.fl_str_mv |
||rbo@sbot.org.br |
_version_ |
1752122361860063232 |