Comparison of Floseals and Tranexamic Acid for Bleeding Control after Total Knee Arthroplasty: a Prospective Randomized Study
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Clinics |
Texto Completo: | https://www.revistas.usp.br/clinics/article/view/164446 |
Resumo: | OBJECTIVE: Tranexamic acid (TXA) and the hemostatic agent Floseals have already been used to minimize bleeding during total knee arthroplasty (TKA). METHODS: We conducted a prospective, randomized study of 90 patients with indications for TKA. Following inclusion, the participants were randomly allocated in blocks to the following 3 groups: control, Floseals and TXA. Bleeding parameters, including decreases in hemoglobin (Hb), drain output, number of blood transfusions and complications, were assessed. ClinicalTrials.gov: NCT02152917. RESULTS: The mean decrease in Hb was highest in the control group (4.81±1.09 g/dL), followed by the Floseals (3.5±1.03 g/dL) and TXA (3.03±1.2 g/dL) groups. The Floseals and TXA groups did not differ, and both performed better than the control group. The mean total drain output was 901.3±695.7 mL in the control group, 546.5±543.5 mL in the TXA group and 331.2±278.7 mL in the Floseals group. Both TXA and Floseals had significantly less output than the control group, and Floseals had significantly less output than TXA. The number of blood transfusions was very small in all 3 groups. CONCLUSION: The use of TXA or Floseals was associated with less blood loss than that of the control group among patients undergoing primary TKA, as measured both directly (intraoperative bleeding + drainage) and on the basis of a decrease in Hb, without differences in the rate of complications. TXA and Floseals showed similar decreases in Hb and total measured blood loss, but the drain output was smaller in the Floseals group. |
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Clinics |
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Comparison of Floseals and Tranexamic Acid for Bleeding Control after Total Knee Arthroplasty: a Prospective Randomized StudyTotal Knee ArthroplastyBleeding ControlTranexamic AcidHemostaticTransfusion RateOBJECTIVE: Tranexamic acid (TXA) and the hemostatic agent Floseals have already been used to minimize bleeding during total knee arthroplasty (TKA). METHODS: We conducted a prospective, randomized study of 90 patients with indications for TKA. Following inclusion, the participants were randomly allocated in blocks to the following 3 groups: control, Floseals and TXA. Bleeding parameters, including decreases in hemoglobin (Hb), drain output, number of blood transfusions and complications, were assessed. ClinicalTrials.gov: NCT02152917. RESULTS: The mean decrease in Hb was highest in the control group (4.81±1.09 g/dL), followed by the Floseals (3.5±1.03 g/dL) and TXA (3.03±1.2 g/dL) groups. The Floseals and TXA groups did not differ, and both performed better than the control group. The mean total drain output was 901.3±695.7 mL in the control group, 546.5±543.5 mL in the TXA group and 331.2±278.7 mL in the Floseals group. Both TXA and Floseals had significantly less output than the control group, and Floseals had significantly less output than TXA. The number of blood transfusions was very small in all 3 groups. CONCLUSION: The use of TXA or Floseals was associated with less blood loss than that of the control group among patients undergoing primary TKA, as measured both directly (intraoperative bleeding + drainage) and on the basis of a decrease in Hb, without differences in the rate of complications. TXA and Floseals showed similar decreases in Hb and total measured blood loss, but the drain output was smaller in the Floseals group.Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo2019-11-27info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/xmlhttps://www.revistas.usp.br/clinics/article/view/16444610.6061/clinics/2019/e1186Clinics; Vol. 74 (2019); e1186Clinics; v. 74 (2019); e1186Clinics; Vol. 74 (2019); e11861980-53221807-5932reponame:Clinicsinstname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/clinics/article/view/164446/157710https://www.revistas.usp.br/clinics/article/view/164446/157711Copyright (c) 2019 Clinicsinfo:eu-repo/semantics/openAccessHelito, Camilo PartezaniBonadio, Marcelo BatistaSobrado, Marcel FaracoGiglio, Pedro NogueiraPécora, José RicardoCamanho, Gilberto LuisDemange, Marco Kawamura2019-11-27T15:52:05Zoai:revistas.usp.br:article/164446Revistahttps://www.revistas.usp.br/clinicsPUBhttps://www.revistas.usp.br/clinics/oai||clinics@hc.fm.usp.br1980-53221807-5932opendoar:2019-11-27T15:52:05Clinics - Universidade de São Paulo (USP)false |
dc.title.none.fl_str_mv |
Comparison of Floseals and Tranexamic Acid for Bleeding Control after Total Knee Arthroplasty: a Prospective Randomized Study |
title |
Comparison of Floseals and Tranexamic Acid for Bleeding Control after Total Knee Arthroplasty: a Prospective Randomized Study |
spellingShingle |
Comparison of Floseals and Tranexamic Acid for Bleeding Control after Total Knee Arthroplasty: a Prospective Randomized Study Helito, Camilo Partezani Total Knee Arthroplasty Bleeding Control Tranexamic Acid Hemostatic Transfusion Rate |
title_short |
Comparison of Floseals and Tranexamic Acid for Bleeding Control after Total Knee Arthroplasty: a Prospective Randomized Study |
title_full |
Comparison of Floseals and Tranexamic Acid for Bleeding Control after Total Knee Arthroplasty: a Prospective Randomized Study |
title_fullStr |
Comparison of Floseals and Tranexamic Acid for Bleeding Control after Total Knee Arthroplasty: a Prospective Randomized Study |
title_full_unstemmed |
Comparison of Floseals and Tranexamic Acid for Bleeding Control after Total Knee Arthroplasty: a Prospective Randomized Study |
title_sort |
Comparison of Floseals and Tranexamic Acid for Bleeding Control after Total Knee Arthroplasty: a Prospective Randomized Study |
author |
Helito, Camilo Partezani |
author_facet |
Helito, Camilo Partezani Bonadio, Marcelo Batista Sobrado, Marcel Faraco Giglio, Pedro Nogueira Pécora, José Ricardo Camanho, Gilberto Luis Demange, Marco Kawamura |
author_role |
author |
author2 |
Bonadio, Marcelo Batista Sobrado, Marcel Faraco Giglio, Pedro Nogueira Pécora, José Ricardo Camanho, Gilberto Luis Demange, Marco Kawamura |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Helito, Camilo Partezani Bonadio, Marcelo Batista Sobrado, Marcel Faraco Giglio, Pedro Nogueira Pécora, José Ricardo Camanho, Gilberto Luis Demange, Marco Kawamura |
dc.subject.por.fl_str_mv |
Total Knee Arthroplasty Bleeding Control Tranexamic Acid Hemostatic Transfusion Rate |
topic |
Total Knee Arthroplasty Bleeding Control Tranexamic Acid Hemostatic Transfusion Rate |
description |
OBJECTIVE: Tranexamic acid (TXA) and the hemostatic agent Floseals have already been used to minimize bleeding during total knee arthroplasty (TKA). METHODS: We conducted a prospective, randomized study of 90 patients with indications for TKA. Following inclusion, the participants were randomly allocated in blocks to the following 3 groups: control, Floseals and TXA. Bleeding parameters, including decreases in hemoglobin (Hb), drain output, number of blood transfusions and complications, were assessed. ClinicalTrials.gov: NCT02152917. RESULTS: The mean decrease in Hb was highest in the control group (4.81±1.09 g/dL), followed by the Floseals (3.5±1.03 g/dL) and TXA (3.03±1.2 g/dL) groups. The Floseals and TXA groups did not differ, and both performed better than the control group. The mean total drain output was 901.3±695.7 mL in the control group, 546.5±543.5 mL in the TXA group and 331.2±278.7 mL in the Floseals group. Both TXA and Floseals had significantly less output than the control group, and Floseals had significantly less output than TXA. The number of blood transfusions was very small in all 3 groups. CONCLUSION: The use of TXA or Floseals was associated with less blood loss than that of the control group among patients undergoing primary TKA, as measured both directly (intraoperative bleeding + drainage) and on the basis of a decrease in Hb, without differences in the rate of complications. TXA and Floseals showed similar decreases in Hb and total measured blood loss, but the drain output was smaller in the Floseals group. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-11-27 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.revistas.usp.br/clinics/article/view/164446 10.6061/clinics/2019/e1186 |
url |
https://www.revistas.usp.br/clinics/article/view/164446 |
identifier_str_mv |
10.6061/clinics/2019/e1186 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://www.revistas.usp.br/clinics/article/view/164446/157710 https://www.revistas.usp.br/clinics/article/view/164446/157711 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2019 Clinics info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2019 Clinics |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf application/xml |
dc.publisher.none.fl_str_mv |
Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo |
publisher.none.fl_str_mv |
Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo |
dc.source.none.fl_str_mv |
Clinics; Vol. 74 (2019); e1186 Clinics; v. 74 (2019); e1186 Clinics; Vol. 74 (2019); e1186 1980-5322 1807-5932 reponame:Clinics instname:Universidade de São Paulo (USP) instacron:USP |
instname_str |
Universidade de São Paulo (USP) |
instacron_str |
USP |
institution |
USP |
reponame_str |
Clinics |
collection |
Clinics |
repository.name.fl_str_mv |
Clinics - Universidade de São Paulo (USP) |
repository.mail.fl_str_mv |
||clinics@hc.fm.usp.br |
_version_ |
1800222764665143296 |