Comparative study of two histopathological classifications for oral squamous cell carcinoma

Detalhes bibliográficos
Autor(a) principal: Longo,Bruna Cristina
Data de Publicação: 2021
Outros Autores: Pereira,Emylle Caroline B. F., Rossi,Débora Cecília N., Pereira,Leonardo S., Coletta,Ricardo D., Morais,Carlos F., Calone,Iris S.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Jornal Brasileiro de Patologia e Medicina Laboratorial (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1676-24442021000100416
Resumo: ABSTRACT Introduction: Squamous cell carcinoma (SCC) is the most common tumor among all cancers in the oral cavity. Despite advances, the prognosis of this neoplasm remains a challenge for professionals. Faced with this situation, several studies try to associate the histopathological analysis with prognosis, so that therapeutic planning becomes more accurate. Objectives: This research aimed to conduct an epidemiological study of oral SCC and classify them histopathological assessment according to the World Health Organization (WHO) and the Budding and Depth of Invasion (BD) model. A retrospective research was conducted. Methodology: Data from medical records filed at UOPECCAN Hospital between 2009 and 2015 were analyzed. The sample consisted of 57 patients. Epidemiological data were collected and the blocks were rescued and cut for histopathological analysis. Associations were performed using the chi-square test with a significance level of 5% (p = 0.05) by the GraphPad Prism program. The two histopathological analyzes were correlated using Spearman’s statistical test. Results: After analyzing the samples, we found a higher prevalence of oral SCC in male smokers aged above 40 years. There was no correlation between the BD and WHO methods. The WHO classification was significantly associated with age (p = 0.03), and follow-up care (p = 0.05). However, the BD model associated lymph node involvement (p = 0.005) and clinical staging (p = 0.005). Conclusion: The BD classification was more objective for histopathological analysis and may be an important tool for analyzing patient prognosis, assisting in the treatment decision.
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spelling Comparative study of two histopathological classifications for oral squamous cell carcinomasquamous cell carcinomaprognosisneoplasm stagingABSTRACT Introduction: Squamous cell carcinoma (SCC) is the most common tumor among all cancers in the oral cavity. Despite advances, the prognosis of this neoplasm remains a challenge for professionals. Faced with this situation, several studies try to associate the histopathological analysis with prognosis, so that therapeutic planning becomes more accurate. Objectives: This research aimed to conduct an epidemiological study of oral SCC and classify them histopathological assessment according to the World Health Organization (WHO) and the Budding and Depth of Invasion (BD) model. A retrospective research was conducted. Methodology: Data from medical records filed at UOPECCAN Hospital between 2009 and 2015 were analyzed. The sample consisted of 57 patients. Epidemiological data were collected and the blocks were rescued and cut for histopathological analysis. Associations were performed using the chi-square test with a significance level of 5% (p = 0.05) by the GraphPad Prism program. The two histopathological analyzes were correlated using Spearman’s statistical test. Results: After analyzing the samples, we found a higher prevalence of oral SCC in male smokers aged above 40 years. There was no correlation between the BD and WHO methods. The WHO classification was significantly associated with age (p = 0.03), and follow-up care (p = 0.05). However, the BD model associated lymph node involvement (p = 0.005) and clinical staging (p = 0.005). Conclusion: The BD classification was more objective for histopathological analysis and may be an important tool for analyzing patient prognosis, assisting in the treatment decision.Sociedade Brasileira de Patologia Clínica2021-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1676-24442021000100416Jornal Brasileiro de Patologia e Medicina Laboratorial v.57 2021reponame:Jornal Brasileiro de Patologia e Medicina Laboratorial (Online)instname:Sociedade Brasileira de Patologia (SBP)instacron:SBP10.5935/1676-2444.20210039info:eu-repo/semantics/openAccessLongo,Bruna CristinaPereira,Emylle Caroline B. F.Rossi,Débora Cecília N.Pereira,Leonardo S.Coletta,Ricardo D.Morais,Carlos F.Calone,Iris S.eng2021-11-25T00:00:00Zoai:scielo:S1676-24442021000100416Revistahttp://www.scielo.br/jbpmlhttps://old.scielo.br/oai/scielo-oai.php||jbpml@sbpc.org.br1678-47741676-2444opendoar:2021-11-25T00:00Jornal Brasileiro de Patologia e Medicina Laboratorial (Online) - Sociedade Brasileira de Patologia (SBP)false
dc.title.none.fl_str_mv Comparative study of two histopathological classifications for oral squamous cell carcinoma
title Comparative study of two histopathological classifications for oral squamous cell carcinoma
spellingShingle Comparative study of two histopathological classifications for oral squamous cell carcinoma
Longo,Bruna Cristina
squamous cell carcinoma
prognosis
neoplasm staging
title_short Comparative study of two histopathological classifications for oral squamous cell carcinoma
title_full Comparative study of two histopathological classifications for oral squamous cell carcinoma
title_fullStr Comparative study of two histopathological classifications for oral squamous cell carcinoma
title_full_unstemmed Comparative study of two histopathological classifications for oral squamous cell carcinoma
title_sort Comparative study of two histopathological classifications for oral squamous cell carcinoma
author Longo,Bruna Cristina
author_facet Longo,Bruna Cristina
Pereira,Emylle Caroline B. F.
Rossi,Débora Cecília N.
Pereira,Leonardo S.
Coletta,Ricardo D.
Morais,Carlos F.
Calone,Iris S.
author_role author
author2 Pereira,Emylle Caroline B. F.
Rossi,Débora Cecília N.
Pereira,Leonardo S.
Coletta,Ricardo D.
Morais,Carlos F.
Calone,Iris S.
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Longo,Bruna Cristina
Pereira,Emylle Caroline B. F.
Rossi,Débora Cecília N.
Pereira,Leonardo S.
Coletta,Ricardo D.
Morais,Carlos F.
Calone,Iris S.
dc.subject.por.fl_str_mv squamous cell carcinoma
prognosis
neoplasm staging
topic squamous cell carcinoma
prognosis
neoplasm staging
description ABSTRACT Introduction: Squamous cell carcinoma (SCC) is the most common tumor among all cancers in the oral cavity. Despite advances, the prognosis of this neoplasm remains a challenge for professionals. Faced with this situation, several studies try to associate the histopathological analysis with prognosis, so that therapeutic planning becomes more accurate. Objectives: This research aimed to conduct an epidemiological study of oral SCC and classify them histopathological assessment according to the World Health Organization (WHO) and the Budding and Depth of Invasion (BD) model. A retrospective research was conducted. Methodology: Data from medical records filed at UOPECCAN Hospital between 2009 and 2015 were analyzed. The sample consisted of 57 patients. Epidemiological data were collected and the blocks were rescued and cut for histopathological analysis. Associations were performed using the chi-square test with a significance level of 5% (p = 0.05) by the GraphPad Prism program. The two histopathological analyzes were correlated using Spearman’s statistical test. Results: After analyzing the samples, we found a higher prevalence of oral SCC in male smokers aged above 40 years. There was no correlation between the BD and WHO methods. The WHO classification was significantly associated with age (p = 0.03), and follow-up care (p = 0.05). However, the BD model associated lymph node involvement (p = 0.005) and clinical staging (p = 0.005). Conclusion: The BD classification was more objective for histopathological analysis and may be an important tool for analyzing patient prognosis, assisting in the treatment decision.
publishDate 2021
dc.date.none.fl_str_mv 2021-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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dc.publisher.none.fl_str_mv
Sociedade Brasileira de Patologia Clínica
publisher.none.fl_str_mv
Sociedade Brasileira de Patologia Clínica
dc.source.none.fl_str_mv Jornal Brasileiro de Patologia e Medicina Laboratorial v.57 2021
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