HOXB5 expression in oral squamous cell carcinoma

Detalhes bibliográficos
Autor(a) principal: Tucci,Renata
Data de Publicação: 2011
Outros Autores: Campos,Marcia Sampaio, Matizonkas-Antonio,Luciana Fasanella, Durazzo,Marcelo, Pinto Junior,Décio dos Santos, Nunes,Fabio Daumas
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Journal of applied oral science (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1678-77572011000200008
Resumo: Human HOX genes encode transcription factors that act as master regulators of embryonic development. They are important in several processes such as cellular morphogenesis and differentiation. The HOXB5 gene in particular has been reported in some types of neoplasm, but not in oral cancer. OBJECTIVE: The present study investigated the expression of HOXB5 in oral squamous cell carcinoma (SCC) and in non-tumoral adjacent tissues, focusing on verifying its possible role as a broad tumor-associated gene and its association with histopathological and clinical (TNM) characteristics. MATERIAL AND METHODS: RT-PCR was performed to amplify HOXB5 mRNA in 15 OSCCs and adjacent non-tumoral epithelium. A possible association with TNM and histopathologic data was verifed by the chi-square and post-hoc t-test. RESULTS: HOXB5 was amplifed in 60% non-tumoral epithelium and in 93.3% carcinomas. No statistically signifcant differences were found regarding the HOXB5 mRNA expression and TNM or histological grade. CONCLUSION: HOXB5 is expressed in OSCCs and its role in cancer progression should be further investigated.
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spelling HOXB5 expression in oral squamous cell carcinomaGenes, homeoboxCarcinoma, squamous cellGene expressionRT-PCR, neoplasm stagingHuman HOX genes encode transcription factors that act as master regulators of embryonic development. They are important in several processes such as cellular morphogenesis and differentiation. The HOXB5 gene in particular has been reported in some types of neoplasm, but not in oral cancer. OBJECTIVE: The present study investigated the expression of HOXB5 in oral squamous cell carcinoma (SCC) and in non-tumoral adjacent tissues, focusing on verifying its possible role as a broad tumor-associated gene and its association with histopathological and clinical (TNM) characteristics. MATERIAL AND METHODS: RT-PCR was performed to amplify HOXB5 mRNA in 15 OSCCs and adjacent non-tumoral epithelium. A possible association with TNM and histopathologic data was verifed by the chi-square and post-hoc t-test. RESULTS: HOXB5 was amplifed in 60% non-tumoral epithelium and in 93.3% carcinomas. No statistically signifcant differences were found regarding the HOXB5 mRNA expression and TNM or histological grade. CONCLUSION: HOXB5 is expressed in OSCCs and its role in cancer progression should be further investigated.Faculdade De Odontologia De Bauru - USP2011-04-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1678-77572011000200008Journal of Applied Oral Science v.19 n.2 2011reponame:Journal of applied oral science (Online)instname:Universidade de São Paulo (USP)instacron:USP10.1590/S1678-77572011000200008info:eu-repo/semantics/openAccessTucci,RenataCampos,Marcia SampaioMatizonkas-Antonio,Luciana FasanellaDurazzo,MarceloPinto Junior,Décio dos SantosNunes,Fabio Daumaseng2011-05-02T00:00:00Zoai:scielo:S1678-77572011000200008Revistahttp://www.scielo.br/jaosPUBhttps://old.scielo.br/oai/scielo-oai.php||jaos@usp.br1678-77651678-7757opendoar:2011-05-02T00:00Journal of applied oral science (Online) - Universidade de São Paulo (USP)false
dc.title.none.fl_str_mv HOXB5 expression in oral squamous cell carcinoma
title HOXB5 expression in oral squamous cell carcinoma
spellingShingle HOXB5 expression in oral squamous cell carcinoma
Tucci,Renata
Genes, homeobox
Carcinoma, squamous cell
Gene expression
RT-PCR, neoplasm staging
title_short HOXB5 expression in oral squamous cell carcinoma
title_full HOXB5 expression in oral squamous cell carcinoma
title_fullStr HOXB5 expression in oral squamous cell carcinoma
title_full_unstemmed HOXB5 expression in oral squamous cell carcinoma
title_sort HOXB5 expression in oral squamous cell carcinoma
author Tucci,Renata
author_facet Tucci,Renata
Campos,Marcia Sampaio
Matizonkas-Antonio,Luciana Fasanella
Durazzo,Marcelo
Pinto Junior,Décio dos Santos
Nunes,Fabio Daumas
author_role author
author2 Campos,Marcia Sampaio
Matizonkas-Antonio,Luciana Fasanella
Durazzo,Marcelo
Pinto Junior,Décio dos Santos
Nunes,Fabio Daumas
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Tucci,Renata
Campos,Marcia Sampaio
Matizonkas-Antonio,Luciana Fasanella
Durazzo,Marcelo
Pinto Junior,Décio dos Santos
Nunes,Fabio Daumas
dc.subject.por.fl_str_mv Genes, homeobox
Carcinoma, squamous cell
Gene expression
RT-PCR, neoplasm staging
topic Genes, homeobox
Carcinoma, squamous cell
Gene expression
RT-PCR, neoplasm staging
description Human HOX genes encode transcription factors that act as master regulators of embryonic development. They are important in several processes such as cellular morphogenesis and differentiation. The HOXB5 gene in particular has been reported in some types of neoplasm, but not in oral cancer. OBJECTIVE: The present study investigated the expression of HOXB5 in oral squamous cell carcinoma (SCC) and in non-tumoral adjacent tissues, focusing on verifying its possible role as a broad tumor-associated gene and its association with histopathological and clinical (TNM) characteristics. MATERIAL AND METHODS: RT-PCR was performed to amplify HOXB5 mRNA in 15 OSCCs and adjacent non-tumoral epithelium. A possible association with TNM and histopathologic data was verifed by the chi-square and post-hoc t-test. RESULTS: HOXB5 was amplifed in 60% non-tumoral epithelium and in 93.3% carcinomas. No statistically signifcant differences were found regarding the HOXB5 mRNA expression and TNM or histological grade. CONCLUSION: HOXB5 is expressed in OSCCs and its role in cancer progression should be further investigated.
publishDate 2011
dc.date.none.fl_str_mv 2011-04-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1678-77572011000200008
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1678-77572011000200008
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S1678-77572011000200008
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Faculdade De Odontologia De Bauru - USP
publisher.none.fl_str_mv Faculdade De Odontologia De Bauru - USP
dc.source.none.fl_str_mv Journal of Applied Oral Science v.19 n.2 2011
reponame:Journal of applied oral science (Online)
instname:Universidade de São Paulo (USP)
instacron:USP
instname_str Universidade de São Paulo (USP)
instacron_str USP
institution USP
reponame_str Journal of applied oral science (Online)
collection Journal of applied oral science (Online)
repository.name.fl_str_mv Journal of applied oral science (Online) - Universidade de São Paulo (USP)
repository.mail.fl_str_mv ||jaos@usp.br
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