Serum levels of interleukin-6 in contacts of active pulmonary tuberculosis

Detalhes bibliográficos
Autor(a) principal: Lopes,Fernando Henrique Azevedo
Data de Publicação: 2013
Outros Autores: Assis,Lívia Coelho de, Pires Neto,Roberto da Justa, Botelho,Karine Paschoal, Sá,Kélvia Miranda, Frota,Cristiane Cunha, Correia,José Walter, Freitas,Max Victor Carioca
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Jornal Brasileiro de Patologia e Medicina Laboratorial (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1676-24442013000600005
Resumo: INTRODUCTION: It is estimated that over two billion individuals are infected by Mycobacterium tuberculosis worldwide. Interleukin-6 (IL-6) is an important cytokine whose serum levels are commonly high in active pulmonary tuberculosis (TB). IL-6 screening in contacts of patients with TB may be useful to monitor the progress of the infectious process and to infer the risk of progression to active disease. OBJECTIVE: To evaluate the serum levels of interleukin-6 in contacts of patients with active pulmonary tuberculosis and to compare them with two other groups: a) patients affected by active pulmonary tuberculosis; b) non-contacts of tuberculosis. METHODS: Cross-sectional study with 15 contacts of patients with active pulmonary tuberculosis, selected according to the protocol recommended by the Ministry of Health. The serum levels of interleukin-6 were measured by Enzyme-linked immunosorbent assay (ELISA). The same test was also applied in the two comparison groups: 38 patients with active pulmonary tuberculosis (confirmed by clinical examination, X-rays of the chest and baciloscopy) and 63 non-contacts (healthy blood donors). RESULTS: In the contact group, the median IL-6 concentration was 1.7 pg/ml (0.96-4.8 pg/ml). For those affected by active pulmonary tuberculosis and non-contact individuals, these values corresponded to 4.3 pg/ml (0.5-24 pg/ml) and 0.5 pg/ml (0-2.8 pg/ml), respectively (p < 0.0001). CONCLUSION: Contacts of patients with active pulmonary tuberculosis had significantly higher IL-6 serum levels (3.4 times higher) in relation to non-contact individuals, but on a lower level (2.5 times lower) when compared to those affected by active disease.
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spelling Serum levels of interleukin-6 in contacts of active pulmonary tuberculosisMycobacterium tuberculosislatent tuberculosistuberculosisinterleukin-6enzyme-linked immunosorbent assayINTRODUCTION: It is estimated that over two billion individuals are infected by Mycobacterium tuberculosis worldwide. Interleukin-6 (IL-6) is an important cytokine whose serum levels are commonly high in active pulmonary tuberculosis (TB). IL-6 screening in contacts of patients with TB may be useful to monitor the progress of the infectious process and to infer the risk of progression to active disease. OBJECTIVE: To evaluate the serum levels of interleukin-6 in contacts of patients with active pulmonary tuberculosis and to compare them with two other groups: a) patients affected by active pulmonary tuberculosis; b) non-contacts of tuberculosis. METHODS: Cross-sectional study with 15 contacts of patients with active pulmonary tuberculosis, selected according to the protocol recommended by the Ministry of Health. The serum levels of interleukin-6 were measured by Enzyme-linked immunosorbent assay (ELISA). The same test was also applied in the two comparison groups: 38 patients with active pulmonary tuberculosis (confirmed by clinical examination, X-rays of the chest and baciloscopy) and 63 non-contacts (healthy blood donors). RESULTS: In the contact group, the median IL-6 concentration was 1.7 pg/ml (0.96-4.8 pg/ml). For those affected by active pulmonary tuberculosis and non-contact individuals, these values corresponded to 4.3 pg/ml (0.5-24 pg/ml) and 0.5 pg/ml (0-2.8 pg/ml), respectively (p < 0.0001). CONCLUSION: Contacts of patients with active pulmonary tuberculosis had significantly higher IL-6 serum levels (3.4 times higher) in relation to non-contact individuals, but on a lower level (2.5 times lower) when compared to those affected by active disease.Sociedade Brasileira de Patologia Clínica2013-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1676-24442013000600005Jornal Brasileiro de Patologia e Medicina Laboratorial v.49 n.6 2013reponame:Jornal Brasileiro de Patologia e Medicina Laboratorial (Online)instname:Sociedade Brasileira de Patologia (SBP)instacron:SBP10.1590/S1676-24442013000600005info:eu-repo/semantics/openAccessLopes,Fernando Henrique AzevedoAssis,Lívia Coelho dePires Neto,Roberto da JustaBotelho,Karine PaschoalSá,Kélvia MirandaFrota,Cristiane CunhaCorreia,José WalterFreitas,Max Victor Cariocaeng2014-01-07T00:00:00Zoai:scielo:S1676-24442013000600005Revistahttp://www.scielo.br/jbpmlhttps://old.scielo.br/oai/scielo-oai.php||jbpml@sbpc.org.br1678-47741676-2444opendoar:2014-01-07T00:00Jornal Brasileiro de Patologia e Medicina Laboratorial (Online) - Sociedade Brasileira de Patologia (SBP)false
dc.title.none.fl_str_mv Serum levels of interleukin-6 in contacts of active pulmonary tuberculosis
title Serum levels of interleukin-6 in contacts of active pulmonary tuberculosis
spellingShingle Serum levels of interleukin-6 in contacts of active pulmonary tuberculosis
Lopes,Fernando Henrique Azevedo
Mycobacterium tuberculosis
latent tuberculosis
tuberculosis
interleukin-6
enzyme-linked immunosorbent assay
title_short Serum levels of interleukin-6 in contacts of active pulmonary tuberculosis
title_full Serum levels of interleukin-6 in contacts of active pulmonary tuberculosis
title_fullStr Serum levels of interleukin-6 in contacts of active pulmonary tuberculosis
title_full_unstemmed Serum levels of interleukin-6 in contacts of active pulmonary tuberculosis
title_sort Serum levels of interleukin-6 in contacts of active pulmonary tuberculosis
author Lopes,Fernando Henrique Azevedo
author_facet Lopes,Fernando Henrique Azevedo
Assis,Lívia Coelho de
Pires Neto,Roberto da Justa
Botelho,Karine Paschoal
Sá,Kélvia Miranda
Frota,Cristiane Cunha
Correia,José Walter
Freitas,Max Victor Carioca
author_role author
author2 Assis,Lívia Coelho de
Pires Neto,Roberto da Justa
Botelho,Karine Paschoal
Sá,Kélvia Miranda
Frota,Cristiane Cunha
Correia,José Walter
Freitas,Max Victor Carioca
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Lopes,Fernando Henrique Azevedo
Assis,Lívia Coelho de
Pires Neto,Roberto da Justa
Botelho,Karine Paschoal
Sá,Kélvia Miranda
Frota,Cristiane Cunha
Correia,José Walter
Freitas,Max Victor Carioca
dc.subject.por.fl_str_mv Mycobacterium tuberculosis
latent tuberculosis
tuberculosis
interleukin-6
enzyme-linked immunosorbent assay
topic Mycobacterium tuberculosis
latent tuberculosis
tuberculosis
interleukin-6
enzyme-linked immunosorbent assay
description INTRODUCTION: It is estimated that over two billion individuals are infected by Mycobacterium tuberculosis worldwide. Interleukin-6 (IL-6) is an important cytokine whose serum levels are commonly high in active pulmonary tuberculosis (TB). IL-6 screening in contacts of patients with TB may be useful to monitor the progress of the infectious process and to infer the risk of progression to active disease. OBJECTIVE: To evaluate the serum levels of interleukin-6 in contacts of patients with active pulmonary tuberculosis and to compare them with two other groups: a) patients affected by active pulmonary tuberculosis; b) non-contacts of tuberculosis. METHODS: Cross-sectional study with 15 contacts of patients with active pulmonary tuberculosis, selected according to the protocol recommended by the Ministry of Health. The serum levels of interleukin-6 were measured by Enzyme-linked immunosorbent assay (ELISA). The same test was also applied in the two comparison groups: 38 patients with active pulmonary tuberculosis (confirmed by clinical examination, X-rays of the chest and baciloscopy) and 63 non-contacts (healthy blood donors). RESULTS: In the contact group, the median IL-6 concentration was 1.7 pg/ml (0.96-4.8 pg/ml). For those affected by active pulmonary tuberculosis and non-contact individuals, these values corresponded to 4.3 pg/ml (0.5-24 pg/ml) and 0.5 pg/ml (0-2.8 pg/ml), respectively (p < 0.0001). CONCLUSION: Contacts of patients with active pulmonary tuberculosis had significantly higher IL-6 serum levels (3.4 times higher) in relation to non-contact individuals, but on a lower level (2.5 times lower) when compared to those affected by active disease.
publishDate 2013
dc.date.none.fl_str_mv 2013-12-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1676-24442013000600005
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dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S1676-24442013000600005
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dc.publisher.none.fl_str_mv
Sociedade Brasileira de Patologia Clínica
publisher.none.fl_str_mv
Sociedade Brasileira de Patologia Clínica
dc.source.none.fl_str_mv Jornal Brasileiro de Patologia e Medicina Laboratorial v.49 n.6 2013
reponame:Jornal Brasileiro de Patologia e Medicina Laboratorial (Online)
instname:Sociedade Brasileira de Patologia (SBP)
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institution SBP
reponame_str Jornal Brasileiro de Patologia e Medicina Laboratorial (Online)
collection Jornal Brasileiro de Patologia e Medicina Laboratorial (Online)
repository.name.fl_str_mv Jornal Brasileiro de Patologia e Medicina Laboratorial (Online) - Sociedade Brasileira de Patologia (SBP)
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