Squamous cell carcinoma of the tongue: clinical and morphological analysis of 57 cases and correlation with prognosis

Detalhes bibliográficos
Autor(a) principal: Vasconcelos,Marcelo Gadelha
Data de Publicação: 2014
Outros Autores: Mafra,Rodrigo Porpino, Vasconcelos,Rodrigo Gadelha, Medeiros,Ana Miryam Costa de, Queiroz,Lélia Maria Guedes
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Jornal Brasileiro de Patologia e Medicina Laboratorial (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1676-24442014000500359
Resumo: Introduction: Oral squamous cell carcinoma (OSCC), which represents more than 90% of head and neck malignant neoplasms, has a poor prognosis due to its high frequency of lymph node metastasis and local invasion. Previous studies have investigated parameters related to the biological behavior of OSCC and its correlation with disease outcome (DO). Objective: To evaluate clinical and morphological data in cases of tongue squamous cell carcinoma (TSCC), correlating these findings with prognosis. Material and methods: Fifty-seven specimens of TSCC were obtained from patients undergoing surgical excision at a referral hospital in Natal, Brazil. Clinical data, such as tumor-node-metastasis (TNM) stage and DO, were collected from medical records. Hematoxylin and eosin-stained sections were analyzed regarding histological grade of malignancy (HGM), based on the system proposed by Bryne (1998) Results: The majority of patients (38.6%) were diagnosed as TNM stage III, and 57.9% developed metastases. Remission of the tumor occurred in 77.2% of the cases. The parameter “metastasis” exhibited a significant association with DO (p = 0) and TNM stage (p = 0.001), thus constituting a good indicator of tumor progression. Correlation of HGM and TNM stage with DO was not evidenced. Nevertheless, statistical analysis showed a significant association between HGM and TNM stage (p = 0.006). Conclusion: TNM clinical staging and HGM, evaluated in association, may be useful to estimate the prognosis of TSCC.
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spelling Squamous cell carcinoma of the tongue: clinical and morphological analysis of 57 cases and correlation with prognosissquamous cell carcinomaoral pathologyprognosis Introduction: Oral squamous cell carcinoma (OSCC), which represents more than 90% of head and neck malignant neoplasms, has a poor prognosis due to its high frequency of lymph node metastasis and local invasion. Previous studies have investigated parameters related to the biological behavior of OSCC and its correlation with disease outcome (DO). Objective: To evaluate clinical and morphological data in cases of tongue squamous cell carcinoma (TSCC), correlating these findings with prognosis. Material and methods: Fifty-seven specimens of TSCC were obtained from patients undergoing surgical excision at a referral hospital in Natal, Brazil. Clinical data, such as tumor-node-metastasis (TNM) stage and DO, were collected from medical records. Hematoxylin and eosin-stained sections were analyzed regarding histological grade of malignancy (HGM), based on the system proposed by Bryne (1998) Results: The majority of patients (38.6%) were diagnosed as TNM stage III, and 57.9% developed metastases. Remission of the tumor occurred in 77.2% of the cases. The parameter “metastasis” exhibited a significant association with DO (p = 0) and TNM stage (p = 0.001), thus constituting a good indicator of tumor progression. Correlation of HGM and TNM stage with DO was not evidenced. Nevertheless, statistical analysis showed a significant association between HGM and TNM stage (p = 0.006). Conclusion: TNM clinical staging and HGM, evaluated in association, may be useful to estimate the prognosis of TSCC. Sociedade Brasileira de Patologia Clínica2014-10-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1676-24442014000500359Jornal Brasileiro de Patologia e Medicina Laboratorial v.50 n.5 2014reponame:Jornal Brasileiro de Patologia e Medicina Laboratorial (Online)instname:Sociedade Brasileira de Patologia (SBP)instacron:SBP10.5935/1676-2444.20140040info:eu-repo/semantics/openAccessVasconcelos,Marcelo GadelhaMafra,Rodrigo PorpinoVasconcelos,Rodrigo GadelhaMedeiros,Ana Miryam Costa deQueiroz,Lélia Maria Guedeseng2014-12-09T00:00:00Zoai:scielo:S1676-24442014000500359Revistahttp://www.scielo.br/jbpmlhttps://old.scielo.br/oai/scielo-oai.php||jbpml@sbpc.org.br1678-47741676-2444opendoar:2014-12-09T00:00Jornal Brasileiro de Patologia e Medicina Laboratorial (Online) - Sociedade Brasileira de Patologia (SBP)false
dc.title.none.fl_str_mv Squamous cell carcinoma of the tongue: clinical and morphological analysis of 57 cases and correlation with prognosis
title Squamous cell carcinoma of the tongue: clinical and morphological analysis of 57 cases and correlation with prognosis
spellingShingle Squamous cell carcinoma of the tongue: clinical and morphological analysis of 57 cases and correlation with prognosis
Vasconcelos,Marcelo Gadelha
squamous cell carcinoma
oral pathology
prognosis
title_short Squamous cell carcinoma of the tongue: clinical and morphological analysis of 57 cases and correlation with prognosis
title_full Squamous cell carcinoma of the tongue: clinical and morphological analysis of 57 cases and correlation with prognosis
title_fullStr Squamous cell carcinoma of the tongue: clinical and morphological analysis of 57 cases and correlation with prognosis
title_full_unstemmed Squamous cell carcinoma of the tongue: clinical and morphological analysis of 57 cases and correlation with prognosis
title_sort Squamous cell carcinoma of the tongue: clinical and morphological analysis of 57 cases and correlation with prognosis
author Vasconcelos,Marcelo Gadelha
author_facet Vasconcelos,Marcelo Gadelha
Mafra,Rodrigo Porpino
Vasconcelos,Rodrigo Gadelha
Medeiros,Ana Miryam Costa de
Queiroz,Lélia Maria Guedes
author_role author
author2 Mafra,Rodrigo Porpino
Vasconcelos,Rodrigo Gadelha
Medeiros,Ana Miryam Costa de
Queiroz,Lélia Maria Guedes
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Vasconcelos,Marcelo Gadelha
Mafra,Rodrigo Porpino
Vasconcelos,Rodrigo Gadelha
Medeiros,Ana Miryam Costa de
Queiroz,Lélia Maria Guedes
dc.subject.por.fl_str_mv squamous cell carcinoma
oral pathology
prognosis
topic squamous cell carcinoma
oral pathology
prognosis
description Introduction: Oral squamous cell carcinoma (OSCC), which represents more than 90% of head and neck malignant neoplasms, has a poor prognosis due to its high frequency of lymph node metastasis and local invasion. Previous studies have investigated parameters related to the biological behavior of OSCC and its correlation with disease outcome (DO). Objective: To evaluate clinical and morphological data in cases of tongue squamous cell carcinoma (TSCC), correlating these findings with prognosis. Material and methods: Fifty-seven specimens of TSCC were obtained from patients undergoing surgical excision at a referral hospital in Natal, Brazil. Clinical data, such as tumor-node-metastasis (TNM) stage and DO, were collected from medical records. Hematoxylin and eosin-stained sections were analyzed regarding histological grade of malignancy (HGM), based on the system proposed by Bryne (1998) Results: The majority of patients (38.6%) were diagnosed as TNM stage III, and 57.9% developed metastases. Remission of the tumor occurred in 77.2% of the cases. The parameter “metastasis” exhibited a significant association with DO (p = 0) and TNM stage (p = 0.001), thus constituting a good indicator of tumor progression. Correlation of HGM and TNM stage with DO was not evidenced. Nevertheless, statistical analysis showed a significant association between HGM and TNM stage (p = 0.006). Conclusion: TNM clinical staging and HGM, evaluated in association, may be useful to estimate the prognosis of TSCC.
publishDate 2014
dc.date.none.fl_str_mv 2014-10-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
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dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1676-24442014000500359
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dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.5935/1676-2444.20140040
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dc.publisher.none.fl_str_mv
Sociedade Brasileira de Patologia Clínica
publisher.none.fl_str_mv
Sociedade Brasileira de Patologia Clínica
dc.source.none.fl_str_mv Jornal Brasileiro de Patologia e Medicina Laboratorial v.50 n.5 2014
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