How pathological criteria can impact prognosis of tongue and floor of the mouth squamous cell carcinoma
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Journal of applied oral science (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1678-77572020000100406 |
Resumo: | Abstract Pathological parameters have been indicated as tumor prognostic factors in oral carcinoma. Objective: The objective of this study was to investigate the impact of pathological parameters on prognosis of patients affected only by tongue and/or floor of the mouth squamous cell carcinoma (SCC). Methodology: In total, 380 patients treated in the Brazilian National Cancer Institute (INCA) from 1999 to 2006 were included. These patients underwent radical resection followed by neck dissection. The clinical and pathological characteristics were recorded. The Kaplan-Meier method and Cox proportional hazards model were used in survival analysis. Overall survival (OS), cancer-specific survival (CSS) and disease-free interval (DFI) were estimated. Cox residuals were evaluated using the R software version 3.5.2. Worst OS, CSS and DFI were observed in patients with tumors in advanced pathological stages (p<0.001), with the presence of perineural invasion (p<0.001) and vascular invasion (p=0.005). Results: Advanced pathological stage and the presence of a poorly differentiated tumor were independent prognostic factors for OS and CSS. However, advanced pathological stage and perineural invasion were independent predictors of a shorter OS, DFI and CSS. Conclusion: Pathological stage and perineural invasion were the most significant pathological variables in survival analysis in tongue and/or floor of the mouth SCC. |
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Journal of applied oral science (Online) |
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How pathological criteria can impact prognosis of tongue and floor of the mouth squamous cell carcinomaOral cancerSquamous cell carcinomaPrognosisSurvivalOral pathologyAbstract Pathological parameters have been indicated as tumor prognostic factors in oral carcinoma. Objective: The objective of this study was to investigate the impact of pathological parameters on prognosis of patients affected only by tongue and/or floor of the mouth squamous cell carcinoma (SCC). Methodology: In total, 380 patients treated in the Brazilian National Cancer Institute (INCA) from 1999 to 2006 were included. These patients underwent radical resection followed by neck dissection. The clinical and pathological characteristics were recorded. The Kaplan-Meier method and Cox proportional hazards model were used in survival analysis. Overall survival (OS), cancer-specific survival (CSS) and disease-free interval (DFI) were estimated. Cox residuals were evaluated using the R software version 3.5.2. Worst OS, CSS and DFI were observed in patients with tumors in advanced pathological stages (p<0.001), with the presence of perineural invasion (p<0.001) and vascular invasion (p=0.005). Results: Advanced pathological stage and the presence of a poorly differentiated tumor were independent prognostic factors for OS and CSS. However, advanced pathological stage and perineural invasion were independent predictors of a shorter OS, DFI and CSS. Conclusion: Pathological stage and perineural invasion were the most significant pathological variables in survival analysis in tongue and/or floor of the mouth SCC.Faculdade De Odontologia De Bauru - USP2020-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1678-77572020000100406Journal of Applied Oral Science v.28 2020reponame:Journal of applied oral science (Online)instname:Universidade de São Paulo (USP)instacron:USP10.1590/1678-7757-2019-0198info:eu-repo/semantics/openAccessRodrigues,Renata MirandaBernardo,Vagner GonçalvesDa Silva,Sabrina DanielaCamisasca,Danielle ResendeFaria,Paulo Antônio de SilvestreDias,Fernando LuizPinto,Luís Felipe RibeiroAlbano,Rodolpho MattosBergmann,AnkeLourenço,Simone de Queiroz Chaveseng2019-11-26T00:00:00Zoai:scielo:S1678-77572020000100406Revistahttp://www.scielo.br/jaosPUBhttps://old.scielo.br/oai/scielo-oai.php||jaos@usp.br1678-77651678-7757opendoar:2019-11-26T00:00Journal of applied oral science (Online) - Universidade de São Paulo (USP)false |
dc.title.none.fl_str_mv |
How pathological criteria can impact prognosis of tongue and floor of the mouth squamous cell carcinoma |
title |
How pathological criteria can impact prognosis of tongue and floor of the mouth squamous cell carcinoma |
spellingShingle |
How pathological criteria can impact prognosis of tongue and floor of the mouth squamous cell carcinoma Rodrigues,Renata Miranda Oral cancer Squamous cell carcinoma Prognosis Survival Oral pathology |
title_short |
How pathological criteria can impact prognosis of tongue and floor of the mouth squamous cell carcinoma |
title_full |
How pathological criteria can impact prognosis of tongue and floor of the mouth squamous cell carcinoma |
title_fullStr |
How pathological criteria can impact prognosis of tongue and floor of the mouth squamous cell carcinoma |
title_full_unstemmed |
How pathological criteria can impact prognosis of tongue and floor of the mouth squamous cell carcinoma |
title_sort |
How pathological criteria can impact prognosis of tongue and floor of the mouth squamous cell carcinoma |
author |
Rodrigues,Renata Miranda |
author_facet |
Rodrigues,Renata Miranda Bernardo,Vagner Gonçalves Da Silva,Sabrina Daniela Camisasca,Danielle Resende Faria,Paulo Antônio de Silvestre Dias,Fernando Luiz Pinto,Luís Felipe Ribeiro Albano,Rodolpho Mattos Bergmann,Anke Lourenço,Simone de Queiroz Chaves |
author_role |
author |
author2 |
Bernardo,Vagner Gonçalves Da Silva,Sabrina Daniela Camisasca,Danielle Resende Faria,Paulo Antônio de Silvestre Dias,Fernando Luiz Pinto,Luís Felipe Ribeiro Albano,Rodolpho Mattos Bergmann,Anke Lourenço,Simone de Queiroz Chaves |
author2_role |
author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Rodrigues,Renata Miranda Bernardo,Vagner Gonçalves Da Silva,Sabrina Daniela Camisasca,Danielle Resende Faria,Paulo Antônio de Silvestre Dias,Fernando Luiz Pinto,Luís Felipe Ribeiro Albano,Rodolpho Mattos Bergmann,Anke Lourenço,Simone de Queiroz Chaves |
dc.subject.por.fl_str_mv |
Oral cancer Squamous cell carcinoma Prognosis Survival Oral pathology |
topic |
Oral cancer Squamous cell carcinoma Prognosis Survival Oral pathology |
description |
Abstract Pathological parameters have been indicated as tumor prognostic factors in oral carcinoma. Objective: The objective of this study was to investigate the impact of pathological parameters on prognosis of patients affected only by tongue and/or floor of the mouth squamous cell carcinoma (SCC). Methodology: In total, 380 patients treated in the Brazilian National Cancer Institute (INCA) from 1999 to 2006 were included. These patients underwent radical resection followed by neck dissection. The clinical and pathological characteristics were recorded. The Kaplan-Meier method and Cox proportional hazards model were used in survival analysis. Overall survival (OS), cancer-specific survival (CSS) and disease-free interval (DFI) were estimated. Cox residuals were evaluated using the R software version 3.5.2. Worst OS, CSS and DFI were observed in patients with tumors in advanced pathological stages (p<0.001), with the presence of perineural invasion (p<0.001) and vascular invasion (p=0.005). Results: Advanced pathological stage and the presence of a poorly differentiated tumor were independent prognostic factors for OS and CSS. However, advanced pathological stage and perineural invasion were independent predictors of a shorter OS, DFI and CSS. Conclusion: Pathological stage and perineural invasion were the most significant pathological variables in survival analysis in tongue and/or floor of the mouth SCC. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1678-77572020000100406 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1678-77572020000100406 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/1678-7757-2019-0198 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Faculdade De Odontologia De Bauru - USP |
publisher.none.fl_str_mv |
Faculdade De Odontologia De Bauru - USP |
dc.source.none.fl_str_mv |
Journal of Applied Oral Science v.28 2020 reponame:Journal of applied oral science (Online) instname:Universidade de São Paulo (USP) instacron:USP |
instname_str |
Universidade de São Paulo (USP) |
instacron_str |
USP |
institution |
USP |
reponame_str |
Journal of applied oral science (Online) |
collection |
Journal of applied oral science (Online) |
repository.name.fl_str_mv |
Journal of applied oral science (Online) - Universidade de São Paulo (USP) |
repository.mail.fl_str_mv |
||jaos@usp.br |
_version_ |
1748936440455102464 |