Do standardization and quantification of histopathological criteria improve the diagnosis of inflammatory bowel disease?

Detalhes bibliográficos
Autor(a) principal: Baldin,Rosimeri Kuhl Svoboda
Data de Publicação: 2014
Outros Autores: Telles,José Ederaldo Queiroz, Bonardi,Renato Araújo, Amarante,Heda Maria Barska dos Santos, Baldin Júnior,Antônio
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Jornal Brasileiro de Patologia e Medicina Laboratorial (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1676-24442014000300221
Resumo: Introduction: Inflammatory bowel disease comprises two major categories: Crohn's disease and ulcerative rectocolitis, both with different clinical and histological aspects, causing sometimes significant morbidity. Objectives: Choose and apply standardized and quantified histopathological diagnosis method, and compare the results and quality index with the original diagnosis. Materials and methods: 43 histological colonoscopic biopsies of 37 patients were re-evaluated by standardized system. Results and discussion: The original diagnoses were more inconclusive (23.3%) than those standardized (2.3%). The agreement with gold standard (clinical, colonoscopical, and radiological diagnosis) was higher on standardized diagnoses (95.3%) than in original (74.4%), especially in relation to Crohn's disease, which percentages were 92.3% and 46.1%, respectively. The quality index was calculated in conclusive diagnosis of each method. For ulcerative rectocolitis, both methods showed sensitivity and negative predictive value of 100%; otherwise the original diagnosis demonstrated specificity of 85.7%, positive predictive value of 96.3% and accuracy of 97.0%, and the standardized diagnosis 92.3%, 96.7% and 97.6%, respectively. For Crohn's disease, there is specificity and positive predictive value of 100% in both methods; the original diagnosis showed sensitivity of 85.7%, negative predictive value of 96.3% and accuracy of 97%, while for the standardized diagnoses 92.3%, 96.7%, and 97.6%, respectively. Conclusion: The standardized diagnosis presented a higher percentage of correct and conclusive diagnoses than those presented in the original diagnosis, especially for Crohn's disease, as well as equal or slightly higher values in some quality index.
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spelling Do standardization and quantification of histopathological criteria improve the diagnosis of inflammatory bowel disease?ulcerative rectocolitisCrohn's diseasebiopsypathology Introduction: Inflammatory bowel disease comprises two major categories: Crohn's disease and ulcerative rectocolitis, both with different clinical and histological aspects, causing sometimes significant morbidity. Objectives: Choose and apply standardized and quantified histopathological diagnosis method, and compare the results and quality index with the original diagnosis. Materials and methods: 43 histological colonoscopic biopsies of 37 patients were re-evaluated by standardized system. Results and discussion: The original diagnoses were more inconclusive (23.3%) than those standardized (2.3%). The agreement with gold standard (clinical, colonoscopical, and radiological diagnosis) was higher on standardized diagnoses (95.3%) than in original (74.4%), especially in relation to Crohn's disease, which percentages were 92.3% and 46.1%, respectively. The quality index was calculated in conclusive diagnosis of each method. For ulcerative rectocolitis, both methods showed sensitivity and negative predictive value of 100%; otherwise the original diagnosis demonstrated specificity of 85.7%, positive predictive value of 96.3% and accuracy of 97.0%, and the standardized diagnosis 92.3%, 96.7% and 97.6%, respectively. For Crohn's disease, there is specificity and positive predictive value of 100% in both methods; the original diagnosis showed sensitivity of 85.7%, negative predictive value of 96.3% and accuracy of 97%, while for the standardized diagnoses 92.3%, 96.7%, and 97.6%, respectively. Conclusion: The standardized diagnosis presented a higher percentage of correct and conclusive diagnoses than those presented in the original diagnosis, especially for Crohn's disease, as well as equal or slightly higher values in some quality index. Sociedade Brasileira de Patologia Clínica2014-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1676-24442014000300221Jornal Brasileiro de Patologia e Medicina Laboratorial v.50 n.3 2014reponame:Jornal Brasileiro de Patologia e Medicina Laboratorial (Online)instname:Sociedade Brasileira de Patologia (SBP)instacron:SBP10.5935/1676-2444.20140019info:eu-repo/semantics/openAccessBaldin,Rosimeri Kuhl SvobodaTelles,José Ederaldo QueirozBonardi,Renato AraújoAmarante,Heda Maria Barska dos SantosBaldin Júnior,Antônioeng2014-10-02T00:00:00Zoai:scielo:S1676-24442014000300221Revistahttp://www.scielo.br/jbpmlhttps://old.scielo.br/oai/scielo-oai.php||jbpml@sbpc.org.br1678-47741676-2444opendoar:2014-10-02T00:00Jornal Brasileiro de Patologia e Medicina Laboratorial (Online) - Sociedade Brasileira de Patologia (SBP)false
dc.title.none.fl_str_mv Do standardization and quantification of histopathological criteria improve the diagnosis of inflammatory bowel disease?
title Do standardization and quantification of histopathological criteria improve the diagnosis of inflammatory bowel disease?
spellingShingle Do standardization and quantification of histopathological criteria improve the diagnosis of inflammatory bowel disease?
Baldin,Rosimeri Kuhl Svoboda
ulcerative rectocolitis
Crohn's disease
biopsy
pathology
title_short Do standardization and quantification of histopathological criteria improve the diagnosis of inflammatory bowel disease?
title_full Do standardization and quantification of histopathological criteria improve the diagnosis of inflammatory bowel disease?
title_fullStr Do standardization and quantification of histopathological criteria improve the diagnosis of inflammatory bowel disease?
title_full_unstemmed Do standardization and quantification of histopathological criteria improve the diagnosis of inflammatory bowel disease?
title_sort Do standardization and quantification of histopathological criteria improve the diagnosis of inflammatory bowel disease?
author Baldin,Rosimeri Kuhl Svoboda
author_facet Baldin,Rosimeri Kuhl Svoboda
Telles,José Ederaldo Queiroz
Bonardi,Renato Araújo
Amarante,Heda Maria Barska dos Santos
Baldin Júnior,Antônio
author_role author
author2 Telles,José Ederaldo Queiroz
Bonardi,Renato Araújo
Amarante,Heda Maria Barska dos Santos
Baldin Júnior,Antônio
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Baldin,Rosimeri Kuhl Svoboda
Telles,José Ederaldo Queiroz
Bonardi,Renato Araújo
Amarante,Heda Maria Barska dos Santos
Baldin Júnior,Antônio
dc.subject.por.fl_str_mv ulcerative rectocolitis
Crohn's disease
biopsy
pathology
topic ulcerative rectocolitis
Crohn's disease
biopsy
pathology
description Introduction: Inflammatory bowel disease comprises two major categories: Crohn's disease and ulcerative rectocolitis, both with different clinical and histological aspects, causing sometimes significant morbidity. Objectives: Choose and apply standardized and quantified histopathological diagnosis method, and compare the results and quality index with the original diagnosis. Materials and methods: 43 histological colonoscopic biopsies of 37 patients were re-evaluated by standardized system. Results and discussion: The original diagnoses were more inconclusive (23.3%) than those standardized (2.3%). The agreement with gold standard (clinical, colonoscopical, and radiological diagnosis) was higher on standardized diagnoses (95.3%) than in original (74.4%), especially in relation to Crohn's disease, which percentages were 92.3% and 46.1%, respectively. The quality index was calculated in conclusive diagnosis of each method. For ulcerative rectocolitis, both methods showed sensitivity and negative predictive value of 100%; otherwise the original diagnosis demonstrated specificity of 85.7%, positive predictive value of 96.3% and accuracy of 97.0%, and the standardized diagnosis 92.3%, 96.7% and 97.6%, respectively. For Crohn's disease, there is specificity and positive predictive value of 100% in both methods; the original diagnosis showed sensitivity of 85.7%, negative predictive value of 96.3% and accuracy of 97%, while for the standardized diagnoses 92.3%, 96.7%, and 97.6%, respectively. Conclusion: The standardized diagnosis presented a higher percentage of correct and conclusive diagnoses than those presented in the original diagnosis, especially for Crohn's disease, as well as equal or slightly higher values in some quality index.
publishDate 2014
dc.date.none.fl_str_mv 2014-06-01
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Sociedade Brasileira de Patologia Clínica
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Sociedade Brasileira de Patologia Clínica
dc.source.none.fl_str_mv Jornal Brasileiro de Patologia e Medicina Laboratorial v.50 n.3 2014
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