Immunomodulatory effects of oral antidiabetic drugs in lymphocyte cultures from patients with type 2 diabetes
Autor(a) principal: | |
---|---|
Data de Publicação: | 2011 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Jornal Brasileiro de Patologia e Medicina Laboratorial (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1676-24442011000100006 |
Resumo: | INTRODUCTION AND OBJECTIVE: It has been suggested that type 2 diabetes is an inflammatory response manifestation. The main drugs used to treat type 2 diabetes are sulphonylureas and biguanides. The aim of this study was to demonstrate the modulatory effects of oral hypoglycemic drugs (chlorpropamide and metformin) on lymphocyte proliferation in vitro and ex vivo. METHODS: Peripheral blood mononuclear cells were isolated from human blood by gradient centrifugation. T-lymphocytes were stimulated by phytohemagglutinin (PHA) and oral hypoglycemic drugs. RESULTS: In both in vitro and ex vivo experiments, there was a reduction in cell proliferation after treatment with oral hypoglycemic drugs. When both drugs were used in combination, a high level of cytotoxicity was observed, which made analysis of immunomodulatory effects unfeasible. DISCUSSION AND CONCLUSION: We demonstrated that diabetes itself may reduce cell proliferation significantly when stimulated by PHA, which may indicate that diabetic patients have difficulties in promoting an efficient inflammatory response. Moreover, the use of oral hypoglycemic drugs may aggravate this situation. |
id |
SBP-1_698ed5ebe6e2c5d828cdb22c51af6d2d |
---|---|
oai_identifier_str |
oai:scielo:S1676-24442011000100006 |
network_acronym_str |
SBP-1 |
network_name_str |
Jornal Brasileiro de Patologia e Medicina Laboratorial (Online) |
repository_id_str |
|
spelling |
Immunomodulatory effects of oral antidiabetic drugs in lymphocyte cultures from patients with type 2 diabetesDiabetes mellitusChlorpropamideMetforminImmunomodulationINTRODUCTION AND OBJECTIVE: It has been suggested that type 2 diabetes is an inflammatory response manifestation. The main drugs used to treat type 2 diabetes are sulphonylureas and biguanides. The aim of this study was to demonstrate the modulatory effects of oral hypoglycemic drugs (chlorpropamide and metformin) on lymphocyte proliferation in vitro and ex vivo. METHODS: Peripheral blood mononuclear cells were isolated from human blood by gradient centrifugation. T-lymphocytes were stimulated by phytohemagglutinin (PHA) and oral hypoglycemic drugs. RESULTS: In both in vitro and ex vivo experiments, there was a reduction in cell proliferation after treatment with oral hypoglycemic drugs. When both drugs were used in combination, a high level of cytotoxicity was observed, which made analysis of immunomodulatory effects unfeasible. DISCUSSION AND CONCLUSION: We demonstrated that diabetes itself may reduce cell proliferation significantly when stimulated by PHA, which may indicate that diabetic patients have difficulties in promoting an efficient inflammatory response. Moreover, the use of oral hypoglycemic drugs may aggravate this situation.Sociedade Brasileira de Patologia Clínica2011-02-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1676-24442011000100006Jornal Brasileiro de Patologia e Medicina Laboratorial v.47 n.1 2011reponame:Jornal Brasileiro de Patologia e Medicina Laboratorial (Online)instname:Sociedade Brasileira de Patologia (SBP)instacron:SBP10.1590/S1676-24442011000100006info:eu-repo/semantics/openAccessMello,Karina FaccioLunardelli,AdroaldoDonadio,Márcio Vinícius FagundesCaberlon,EduardoOliveira,Carmen Silvana Araújo deBastos,Carolina Maria AlvesPires,Melissa Guerra SimõesNunes,Fernanda BordignonOliveira,Jarbas Rodrigues deeng2011-03-14T00:00:00Zoai:scielo:S1676-24442011000100006Revistahttp://www.scielo.br/jbpmlhttps://old.scielo.br/oai/scielo-oai.php||jbpml@sbpc.org.br1678-47741676-2444opendoar:2011-03-14T00:00Jornal Brasileiro de Patologia e Medicina Laboratorial (Online) - Sociedade Brasileira de Patologia (SBP)false |
dc.title.none.fl_str_mv |
Immunomodulatory effects of oral antidiabetic drugs in lymphocyte cultures from patients with type 2 diabetes |
title |
Immunomodulatory effects of oral antidiabetic drugs in lymphocyte cultures from patients with type 2 diabetes |
spellingShingle |
Immunomodulatory effects of oral antidiabetic drugs in lymphocyte cultures from patients with type 2 diabetes Mello,Karina Faccio Diabetes mellitus Chlorpropamide Metformin Immunomodulation |
title_short |
Immunomodulatory effects of oral antidiabetic drugs in lymphocyte cultures from patients with type 2 diabetes |
title_full |
Immunomodulatory effects of oral antidiabetic drugs in lymphocyte cultures from patients with type 2 diabetes |
title_fullStr |
Immunomodulatory effects of oral antidiabetic drugs in lymphocyte cultures from patients with type 2 diabetes |
title_full_unstemmed |
Immunomodulatory effects of oral antidiabetic drugs in lymphocyte cultures from patients with type 2 diabetes |
title_sort |
Immunomodulatory effects of oral antidiabetic drugs in lymphocyte cultures from patients with type 2 diabetes |
author |
Mello,Karina Faccio |
author_facet |
Mello,Karina Faccio Lunardelli,Adroaldo Donadio,Márcio Vinícius Fagundes Caberlon,Eduardo Oliveira,Carmen Silvana Araújo de Bastos,Carolina Maria Alves Pires,Melissa Guerra Simões Nunes,Fernanda Bordignon Oliveira,Jarbas Rodrigues de |
author_role |
author |
author2 |
Lunardelli,Adroaldo Donadio,Márcio Vinícius Fagundes Caberlon,Eduardo Oliveira,Carmen Silvana Araújo de Bastos,Carolina Maria Alves Pires,Melissa Guerra Simões Nunes,Fernanda Bordignon Oliveira,Jarbas Rodrigues de |
author2_role |
author author author author author author author author |
dc.contributor.author.fl_str_mv |
Mello,Karina Faccio Lunardelli,Adroaldo Donadio,Márcio Vinícius Fagundes Caberlon,Eduardo Oliveira,Carmen Silvana Araújo de Bastos,Carolina Maria Alves Pires,Melissa Guerra Simões Nunes,Fernanda Bordignon Oliveira,Jarbas Rodrigues de |
dc.subject.por.fl_str_mv |
Diabetes mellitus Chlorpropamide Metformin Immunomodulation |
topic |
Diabetes mellitus Chlorpropamide Metformin Immunomodulation |
description |
INTRODUCTION AND OBJECTIVE: It has been suggested that type 2 diabetes is an inflammatory response manifestation. The main drugs used to treat type 2 diabetes are sulphonylureas and biguanides. The aim of this study was to demonstrate the modulatory effects of oral hypoglycemic drugs (chlorpropamide and metformin) on lymphocyte proliferation in vitro and ex vivo. METHODS: Peripheral blood mononuclear cells were isolated from human blood by gradient centrifugation. T-lymphocytes were stimulated by phytohemagglutinin (PHA) and oral hypoglycemic drugs. RESULTS: In both in vitro and ex vivo experiments, there was a reduction in cell proliferation after treatment with oral hypoglycemic drugs. When both drugs were used in combination, a high level of cytotoxicity was observed, which made analysis of immunomodulatory effects unfeasible. DISCUSSION AND CONCLUSION: We demonstrated that diabetes itself may reduce cell proliferation significantly when stimulated by PHA, which may indicate that diabetic patients have difficulties in promoting an efficient inflammatory response. Moreover, the use of oral hypoglycemic drugs may aggravate this situation. |
publishDate |
2011 |
dc.date.none.fl_str_mv |
2011-02-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1676-24442011000100006 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1676-24442011000100006 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S1676-24442011000100006 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Patologia Clínica |
publisher.none.fl_str_mv |
Sociedade Brasileira de Patologia Clínica |
dc.source.none.fl_str_mv |
Jornal Brasileiro de Patologia e Medicina Laboratorial v.47 n.1 2011 reponame:Jornal Brasileiro de Patologia e Medicina Laboratorial (Online) instname:Sociedade Brasileira de Patologia (SBP) instacron:SBP |
instname_str |
Sociedade Brasileira de Patologia (SBP) |
instacron_str |
SBP |
institution |
SBP |
reponame_str |
Jornal Brasileiro de Patologia e Medicina Laboratorial (Online) |
collection |
Jornal Brasileiro de Patologia e Medicina Laboratorial (Online) |
repository.name.fl_str_mv |
Jornal Brasileiro de Patologia e Medicina Laboratorial (Online) - Sociedade Brasileira de Patologia (SBP) |
repository.mail.fl_str_mv |
||jbpml@sbpc.org.br |
_version_ |
1752122295310090240 |