HER2-expressing breast tumors are associated with breast cancer stem-cell phenotype CD44+/CD24-
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Jornal Brasileiro de Patologia e Medicina Laboratorial (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1676-24442018000500310 |
Resumo: | ABSTRACT INTRODUCTION: According to the cancer stem-cell theory, tumors originate from a small population of cancer stem cells, which lose the mechanism of self-regulation and begin to differentiate and proliferate indefinitely. The CD44+/CD24- phenotype may be considered a stem-cell marker in breast cancer. OBJECTIVE: To evaluate the correlation between CD44+/CD24- phenotype and different molecular subtypes of breast cancer in invasive ductal carcinoma samples. METHODS: The expression of CD44, CD44v6, and CD24 markers was investigated in 133 cases of invasive mammary carcinoma with immunohistochemistry. CD44+/CD24- phenotype was identified and correlated with the molecular subtypes and classical prognostic factors such as age, histological grade, tumor size, and lymph node status. RESULTS: Eighteen (14%) cases were positive for CD44+/CD24- (CD44+/CD24- or CD44v6+/CD24-) phenotype; among these, 11.1%, 27.8%, 38.9%, and 22.2% were luminal, luminal B-human epidermal growth factor receptor 2 (HER2), HER2, and triple-negative subtype, respectively. CD44+/ CD24- phenotype was more common in HER2 subgroup (p = 0.0197). CONCLUSION: CD44+/CD24- phenotype was correlated with molecular subtypes of breast cancer. The highest expression of CD44+/CD24- phenotype was reported in patients with HER2+ disease, a molecular subtype associated with more aggressive behavior and worse prognosis. |
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Jornal Brasileiro de Patologia e Medicina Laboratorial (Online) |
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HER2-expressing breast tumors are associated with breast cancer stem-cell phenotype CD44+/CD24-breast neoplasmsneoplastic stem cellsCD44 antigensCD24 antigensbreast ductal carcinomaABSTRACT INTRODUCTION: According to the cancer stem-cell theory, tumors originate from a small population of cancer stem cells, which lose the mechanism of self-regulation and begin to differentiate and proliferate indefinitely. The CD44+/CD24- phenotype may be considered a stem-cell marker in breast cancer. OBJECTIVE: To evaluate the correlation between CD44+/CD24- phenotype and different molecular subtypes of breast cancer in invasive ductal carcinoma samples. METHODS: The expression of CD44, CD44v6, and CD24 markers was investigated in 133 cases of invasive mammary carcinoma with immunohistochemistry. CD44+/CD24- phenotype was identified and correlated with the molecular subtypes and classical prognostic factors such as age, histological grade, tumor size, and lymph node status. RESULTS: Eighteen (14%) cases were positive for CD44+/CD24- (CD44+/CD24- or CD44v6+/CD24-) phenotype; among these, 11.1%, 27.8%, 38.9%, and 22.2% were luminal, luminal B-human epidermal growth factor receptor 2 (HER2), HER2, and triple-negative subtype, respectively. CD44+/ CD24- phenotype was more common in HER2 subgroup (p = 0.0197). CONCLUSION: CD44+/CD24- phenotype was correlated with molecular subtypes of breast cancer. The highest expression of CD44+/CD24- phenotype was reported in patients with HER2+ disease, a molecular subtype associated with more aggressive behavior and worse prognosis.Sociedade Brasileira de Patologia Clínica2018-10-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1676-24442018000500310Jornal Brasileiro de Patologia e Medicina Laboratorial v.54 n.5 2018reponame:Jornal Brasileiro de Patologia e Medicina Laboratorial (Online)instname:Sociedade Brasileira de Patologia (SBP)instacron:SBP10.5935/1676-2444.20180052info:eu-repo/semantics/openAccessRabinovich,IrisNoronha,Lúcia deSebastião,Ana Paula M.Lima,Rubens S.Urban,Cícero A.Schunemann Jr.,EduardoElífio-Esposito,SeleneSpautz,Cleverton C.Moreno-Amaral,Andréa N.eng2018-12-03T00:00:00Zoai:scielo:S1676-24442018000500310Revistahttp://www.scielo.br/jbpmlhttps://old.scielo.br/oai/scielo-oai.php||jbpml@sbpc.org.br1678-47741676-2444opendoar:2018-12-03T00:00Jornal Brasileiro de Patologia e Medicina Laboratorial (Online) - Sociedade Brasileira de Patologia (SBP)false |
dc.title.none.fl_str_mv |
HER2-expressing breast tumors are associated with breast cancer stem-cell phenotype CD44+/CD24- |
title |
HER2-expressing breast tumors are associated with breast cancer stem-cell phenotype CD44+/CD24- |
spellingShingle |
HER2-expressing breast tumors are associated with breast cancer stem-cell phenotype CD44+/CD24- Rabinovich,Iris breast neoplasms neoplastic stem cells CD44 antigens CD24 antigens breast ductal carcinoma |
title_short |
HER2-expressing breast tumors are associated with breast cancer stem-cell phenotype CD44+/CD24- |
title_full |
HER2-expressing breast tumors are associated with breast cancer stem-cell phenotype CD44+/CD24- |
title_fullStr |
HER2-expressing breast tumors are associated with breast cancer stem-cell phenotype CD44+/CD24- |
title_full_unstemmed |
HER2-expressing breast tumors are associated with breast cancer stem-cell phenotype CD44+/CD24- |
title_sort |
HER2-expressing breast tumors are associated with breast cancer stem-cell phenotype CD44+/CD24- |
author |
Rabinovich,Iris |
author_facet |
Rabinovich,Iris Noronha,Lúcia de Sebastião,Ana Paula M. Lima,Rubens S. Urban,Cícero A. Schunemann Jr.,Eduardo Elífio-Esposito,Selene Spautz,Cleverton C. Moreno-Amaral,Andréa N. |
author_role |
author |
author2 |
Noronha,Lúcia de Sebastião,Ana Paula M. Lima,Rubens S. Urban,Cícero A. Schunemann Jr.,Eduardo Elífio-Esposito,Selene Spautz,Cleverton C. Moreno-Amaral,Andréa N. |
author2_role |
author author author author author author author author |
dc.contributor.author.fl_str_mv |
Rabinovich,Iris Noronha,Lúcia de Sebastião,Ana Paula M. Lima,Rubens S. Urban,Cícero A. Schunemann Jr.,Eduardo Elífio-Esposito,Selene Spautz,Cleverton C. Moreno-Amaral,Andréa N. |
dc.subject.por.fl_str_mv |
breast neoplasms neoplastic stem cells CD44 antigens CD24 antigens breast ductal carcinoma |
topic |
breast neoplasms neoplastic stem cells CD44 antigens CD24 antigens breast ductal carcinoma |
description |
ABSTRACT INTRODUCTION: According to the cancer stem-cell theory, tumors originate from a small population of cancer stem cells, which lose the mechanism of self-regulation and begin to differentiate and proliferate indefinitely. The CD44+/CD24- phenotype may be considered a stem-cell marker in breast cancer. OBJECTIVE: To evaluate the correlation between CD44+/CD24- phenotype and different molecular subtypes of breast cancer in invasive ductal carcinoma samples. METHODS: The expression of CD44, CD44v6, and CD24 markers was investigated in 133 cases of invasive mammary carcinoma with immunohistochemistry. CD44+/CD24- phenotype was identified and correlated with the molecular subtypes and classical prognostic factors such as age, histological grade, tumor size, and lymph node status. RESULTS: Eighteen (14%) cases were positive for CD44+/CD24- (CD44+/CD24- or CD44v6+/CD24-) phenotype; among these, 11.1%, 27.8%, 38.9%, and 22.2% were luminal, luminal B-human epidermal growth factor receptor 2 (HER2), HER2, and triple-negative subtype, respectively. CD44+/ CD24- phenotype was more common in HER2 subgroup (p = 0.0197). CONCLUSION: CD44+/CD24- phenotype was correlated with molecular subtypes of breast cancer. The highest expression of CD44+/CD24- phenotype was reported in patients with HER2+ disease, a molecular subtype associated with more aggressive behavior and worse prognosis. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-10-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1676-24442018000500310 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1676-24442018000500310 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.5935/1676-2444.20180052 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Patologia Clínica |
publisher.none.fl_str_mv |
Sociedade Brasileira de Patologia Clínica |
dc.source.none.fl_str_mv |
Jornal Brasileiro de Patologia e Medicina Laboratorial v.54 n.5 2018 reponame:Jornal Brasileiro de Patologia e Medicina Laboratorial (Online) instname:Sociedade Brasileira de Patologia (SBP) instacron:SBP |
instname_str |
Sociedade Brasileira de Patologia (SBP) |
instacron_str |
SBP |
institution |
SBP |
reponame_str |
Jornal Brasileiro de Patologia e Medicina Laboratorial (Online) |
collection |
Jornal Brasileiro de Patologia e Medicina Laboratorial (Online) |
repository.name.fl_str_mv |
Jornal Brasileiro de Patologia e Medicina Laboratorial (Online) - Sociedade Brasileira de Patologia (SBP) |
repository.mail.fl_str_mv |
||jbpml@sbpc.org.br |
_version_ |
1752122297149292544 |