HER2-expressing breast tumors are associated with breast cancer stem-cell phenotype CD44+/CD24-

Detalhes bibliográficos
Autor(a) principal: Rabinovich,Iris
Data de Publicação: 2018
Outros Autores: Noronha,Lúcia de, Sebastião,Ana Paula M., Lima,Rubens S., Urban,Cícero A., Schunemann Jr.,Eduardo, Elífio-Esposito,Selene, Spautz,Cleverton C., Moreno-Amaral,Andréa N.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Jornal Brasileiro de Patologia e Medicina Laboratorial (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1676-24442018000500310
Resumo: ABSTRACT INTRODUCTION: According to the cancer stem-cell theory, tumors originate from a small population of cancer stem cells, which lose the mechanism of self-regulation and begin to differentiate and proliferate indefinitely. The CD44+/CD24- phenotype may be considered a stem-cell marker in breast cancer. OBJECTIVE: To evaluate the correlation between CD44+/CD24- phenotype and different molecular subtypes of breast cancer in invasive ductal carcinoma samples. METHODS: The expression of CD44, CD44v6, and CD24 markers was investigated in 133 cases of invasive mammary carcinoma with immunohistochemistry. CD44+/CD24- phenotype was identified and correlated with the molecular subtypes and classical prognostic factors such as age, histological grade, tumor size, and lymph node status. RESULTS: Eighteen (14%) cases were positive for CD44+/CD24- (CD44+/CD24- or CD44v6+/CD24-) phenotype; among these, 11.1%, 27.8%, 38.9%, and 22.2% were luminal, luminal B-human epidermal growth factor receptor 2 (HER2), HER2, and triple-negative subtype, respectively. CD44+/ CD24- phenotype was more common in HER2 subgroup (p = 0.0197). CONCLUSION: CD44+/CD24- phenotype was correlated with molecular subtypes of breast cancer. The highest expression of CD44+/CD24- phenotype was reported in patients with HER2+ disease, a molecular subtype associated with more aggressive behavior and worse prognosis.
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spelling HER2-expressing breast tumors are associated with breast cancer stem-cell phenotype CD44+/CD24-breast neoplasmsneoplastic stem cellsCD44 antigensCD24 antigensbreast ductal carcinomaABSTRACT INTRODUCTION: According to the cancer stem-cell theory, tumors originate from a small population of cancer stem cells, which lose the mechanism of self-regulation and begin to differentiate and proliferate indefinitely. The CD44+/CD24- phenotype may be considered a stem-cell marker in breast cancer. OBJECTIVE: To evaluate the correlation between CD44+/CD24- phenotype and different molecular subtypes of breast cancer in invasive ductal carcinoma samples. METHODS: The expression of CD44, CD44v6, and CD24 markers was investigated in 133 cases of invasive mammary carcinoma with immunohistochemistry. CD44+/CD24- phenotype was identified and correlated with the molecular subtypes and classical prognostic factors such as age, histological grade, tumor size, and lymph node status. RESULTS: Eighteen (14%) cases were positive for CD44+/CD24- (CD44+/CD24- or CD44v6+/CD24-) phenotype; among these, 11.1%, 27.8%, 38.9%, and 22.2% were luminal, luminal B-human epidermal growth factor receptor 2 (HER2), HER2, and triple-negative subtype, respectively. CD44+/ CD24- phenotype was more common in HER2 subgroup (p = 0.0197). CONCLUSION: CD44+/CD24- phenotype was correlated with molecular subtypes of breast cancer. The highest expression of CD44+/CD24- phenotype was reported in patients with HER2+ disease, a molecular subtype associated with more aggressive behavior and worse prognosis.Sociedade Brasileira de Patologia Clínica2018-10-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1676-24442018000500310Jornal Brasileiro de Patologia e Medicina Laboratorial v.54 n.5 2018reponame:Jornal Brasileiro de Patologia e Medicina Laboratorial (Online)instname:Sociedade Brasileira de Patologia (SBP)instacron:SBP10.5935/1676-2444.20180052info:eu-repo/semantics/openAccessRabinovich,IrisNoronha,Lúcia deSebastião,Ana Paula M.Lima,Rubens S.Urban,Cícero A.Schunemann Jr.,EduardoElífio-Esposito,SeleneSpautz,Cleverton C.Moreno-Amaral,Andréa N.eng2018-12-03T00:00:00Zoai:scielo:S1676-24442018000500310Revistahttp://www.scielo.br/jbpmlhttps://old.scielo.br/oai/scielo-oai.php||jbpml@sbpc.org.br1678-47741676-2444opendoar:2018-12-03T00:00Jornal Brasileiro de Patologia e Medicina Laboratorial (Online) - Sociedade Brasileira de Patologia (SBP)false
dc.title.none.fl_str_mv HER2-expressing breast tumors are associated with breast cancer stem-cell phenotype CD44+/CD24-
title HER2-expressing breast tumors are associated with breast cancer stem-cell phenotype CD44+/CD24-
spellingShingle HER2-expressing breast tumors are associated with breast cancer stem-cell phenotype CD44+/CD24-
Rabinovich,Iris
breast neoplasms
neoplastic stem cells
CD44 antigens
CD24 antigens
breast ductal carcinoma
title_short HER2-expressing breast tumors are associated with breast cancer stem-cell phenotype CD44+/CD24-
title_full HER2-expressing breast tumors are associated with breast cancer stem-cell phenotype CD44+/CD24-
title_fullStr HER2-expressing breast tumors are associated with breast cancer stem-cell phenotype CD44+/CD24-
title_full_unstemmed HER2-expressing breast tumors are associated with breast cancer stem-cell phenotype CD44+/CD24-
title_sort HER2-expressing breast tumors are associated with breast cancer stem-cell phenotype CD44+/CD24-
author Rabinovich,Iris
author_facet Rabinovich,Iris
Noronha,Lúcia de
Sebastião,Ana Paula M.
Lima,Rubens S.
Urban,Cícero A.
Schunemann Jr.,Eduardo
Elífio-Esposito,Selene
Spautz,Cleverton C.
Moreno-Amaral,Andréa N.
author_role author
author2 Noronha,Lúcia de
Sebastião,Ana Paula M.
Lima,Rubens S.
Urban,Cícero A.
Schunemann Jr.,Eduardo
Elífio-Esposito,Selene
Spautz,Cleverton C.
Moreno-Amaral,Andréa N.
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Rabinovich,Iris
Noronha,Lúcia de
Sebastião,Ana Paula M.
Lima,Rubens S.
Urban,Cícero A.
Schunemann Jr.,Eduardo
Elífio-Esposito,Selene
Spautz,Cleverton C.
Moreno-Amaral,Andréa N.
dc.subject.por.fl_str_mv breast neoplasms
neoplastic stem cells
CD44 antigens
CD24 antigens
breast ductal carcinoma
topic breast neoplasms
neoplastic stem cells
CD44 antigens
CD24 antigens
breast ductal carcinoma
description ABSTRACT INTRODUCTION: According to the cancer stem-cell theory, tumors originate from a small population of cancer stem cells, which lose the mechanism of self-regulation and begin to differentiate and proliferate indefinitely. The CD44+/CD24- phenotype may be considered a stem-cell marker in breast cancer. OBJECTIVE: To evaluate the correlation between CD44+/CD24- phenotype and different molecular subtypes of breast cancer in invasive ductal carcinoma samples. METHODS: The expression of CD44, CD44v6, and CD24 markers was investigated in 133 cases of invasive mammary carcinoma with immunohistochemistry. CD44+/CD24- phenotype was identified and correlated with the molecular subtypes and classical prognostic factors such as age, histological grade, tumor size, and lymph node status. RESULTS: Eighteen (14%) cases were positive for CD44+/CD24- (CD44+/CD24- or CD44v6+/CD24-) phenotype; among these, 11.1%, 27.8%, 38.9%, and 22.2% were luminal, luminal B-human epidermal growth factor receptor 2 (HER2), HER2, and triple-negative subtype, respectively. CD44+/ CD24- phenotype was more common in HER2 subgroup (p = 0.0197). CONCLUSION: CD44+/CD24- phenotype was correlated with molecular subtypes of breast cancer. The highest expression of CD44+/CD24- phenotype was reported in patients with HER2+ disease, a molecular subtype associated with more aggressive behavior and worse prognosis.
publishDate 2018
dc.date.none.fl_str_mv 2018-10-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1676-24442018000500310
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1676-24442018000500310
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.5935/1676-2444.20180052
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv
Sociedade Brasileira de Patologia Clínica
publisher.none.fl_str_mv
Sociedade Brasileira de Patologia Clínica
dc.source.none.fl_str_mv Jornal Brasileiro de Patologia e Medicina Laboratorial v.54 n.5 2018
reponame:Jornal Brasileiro de Patologia e Medicina Laboratorial (Online)
instname:Sociedade Brasileira de Patologia (SBP)
instacron:SBP
instname_str Sociedade Brasileira de Patologia (SBP)
instacron_str SBP
institution SBP
reponame_str Jornal Brasileiro de Patologia e Medicina Laboratorial (Online)
collection Jornal Brasileiro de Patologia e Medicina Laboratorial (Online)
repository.name.fl_str_mv Jornal Brasileiro de Patologia e Medicina Laboratorial (Online) - Sociedade Brasileira de Patologia (SBP)
repository.mail.fl_str_mv ||jbpml@sbpc.org.br
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