Expression of Epstein-Barr virus in patients with Hodgkin's disease: report of 64 cases from Rio de Janeiro, Brazil

Detalhes bibliográficos
Autor(a) principal: Loureiro,Monique Morgado
Data de Publicação: 2004
Outros Autores: Morais,José Carlos, Milito,Cristiane Bedran, Portugal,Rodrigo Doyle, Pulcheri,Wolmar, Spector,Nelson
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Jornal Brasileiro de Patologia e Medicina Laboratorial (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1676-24442004000100010
Resumo: Epstein-Barr virus (EBV) has been implicated in the pathogenesis of Hodgkin's disease (HD), and the association between EBV and HD is influenced by the patients' socioeconomic status, age and the presence of mixed cellularity (MC) histological subtype. The prevalence of EBV in HD varies widely. This study was undertaken to determine the prevalence of EBV in HD in a Brazilian population. We studied 64 cases with a monoclonal antibody to the EBV latent membrane protein-1 (LMP1). EBV was detected in 35 of the 64 cases (55%) and its presence was significantly correlated with the MC subtype (OR = 9; IC 95% = 1.66 - 66; p = 0,0015). These results support that EBV is related to HD in a Brazilian population.
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spelling Expression of Epstein-Barr virus in patients with Hodgkin's disease: report of 64 cases from Rio de Janeiro, BrazilHodgkin's diseaseEpstein-Barr virusLMP1Epstein-Barr virus (EBV) has been implicated in the pathogenesis of Hodgkin's disease (HD), and the association between EBV and HD is influenced by the patients' socioeconomic status, age and the presence of mixed cellularity (MC) histological subtype. The prevalence of EBV in HD varies widely. This study was undertaken to determine the prevalence of EBV in HD in a Brazilian population. We studied 64 cases with a monoclonal antibody to the EBV latent membrane protein-1 (LMP1). EBV was detected in 35 of the 64 cases (55%) and its presence was significantly correlated with the MC subtype (OR = 9; IC 95% = 1.66 - 66; p = 0,0015). These results support that EBV is related to HD in a Brazilian population.Sociedade Brasileira de Patologia Clínica2004-02-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1676-24442004000100010Jornal Brasileiro de Patologia e Medicina Laboratorial v.40 n.1 2004reponame:Jornal Brasileiro de Patologia e Medicina Laboratorial (Online)instname:Sociedade Brasileira de Patologia (SBP)instacron:SBP10.1590/S1676-24442004000100010info:eu-repo/semantics/openAccessLoureiro,Monique MorgadoMorais,José CarlosMilito,Cristiane BedranPortugal,Rodrigo DoylePulcheri,WolmarSpector,Nelsoneng2004-06-08T00:00:00Zoai:scielo:S1676-24442004000100010Revistahttp://www.scielo.br/jbpmlhttps://old.scielo.br/oai/scielo-oai.php||jbpml@sbpc.org.br1678-47741676-2444opendoar:2004-06-08T00:00Jornal Brasileiro de Patologia e Medicina Laboratorial (Online) - Sociedade Brasileira de Patologia (SBP)false
dc.title.none.fl_str_mv Expression of Epstein-Barr virus in patients with Hodgkin's disease: report of 64 cases from Rio de Janeiro, Brazil
title Expression of Epstein-Barr virus in patients with Hodgkin's disease: report of 64 cases from Rio de Janeiro, Brazil
spellingShingle Expression of Epstein-Barr virus in patients with Hodgkin's disease: report of 64 cases from Rio de Janeiro, Brazil
Loureiro,Monique Morgado
Hodgkin's disease
Epstein-Barr virus
LMP1
title_short Expression of Epstein-Barr virus in patients with Hodgkin's disease: report of 64 cases from Rio de Janeiro, Brazil
title_full Expression of Epstein-Barr virus in patients with Hodgkin's disease: report of 64 cases from Rio de Janeiro, Brazil
title_fullStr Expression of Epstein-Barr virus in patients with Hodgkin's disease: report of 64 cases from Rio de Janeiro, Brazil
title_full_unstemmed Expression of Epstein-Barr virus in patients with Hodgkin's disease: report of 64 cases from Rio de Janeiro, Brazil
title_sort Expression of Epstein-Barr virus in patients with Hodgkin's disease: report of 64 cases from Rio de Janeiro, Brazil
author Loureiro,Monique Morgado
author_facet Loureiro,Monique Morgado
Morais,José Carlos
Milito,Cristiane Bedran
Portugal,Rodrigo Doyle
Pulcheri,Wolmar
Spector,Nelson
author_role author
author2 Morais,José Carlos
Milito,Cristiane Bedran
Portugal,Rodrigo Doyle
Pulcheri,Wolmar
Spector,Nelson
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Loureiro,Monique Morgado
Morais,José Carlos
Milito,Cristiane Bedran
Portugal,Rodrigo Doyle
Pulcheri,Wolmar
Spector,Nelson
dc.subject.por.fl_str_mv Hodgkin's disease
Epstein-Barr virus
LMP1
topic Hodgkin's disease
Epstein-Barr virus
LMP1
description Epstein-Barr virus (EBV) has been implicated in the pathogenesis of Hodgkin's disease (HD), and the association between EBV and HD is influenced by the patients' socioeconomic status, age and the presence of mixed cellularity (MC) histological subtype. The prevalence of EBV in HD varies widely. This study was undertaken to determine the prevalence of EBV in HD in a Brazilian population. We studied 64 cases with a monoclonal antibody to the EBV latent membrane protein-1 (LMP1). EBV was detected in 35 of the 64 cases (55%) and its presence was significantly correlated with the MC subtype (OR = 9; IC 95% = 1.66 - 66; p = 0,0015). These results support that EBV is related to HD in a Brazilian population.
publishDate 2004
dc.date.none.fl_str_mv 2004-02-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1676-24442004000100010
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dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S1676-24442004000100010
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Sociedade Brasileira de Patologia Clínica
publisher.none.fl_str_mv
Sociedade Brasileira de Patologia Clínica
dc.source.none.fl_str_mv Jornal Brasileiro de Patologia e Medicina Laboratorial v.40 n.1 2004
reponame:Jornal Brasileiro de Patologia e Medicina Laboratorial (Online)
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