Analysis of the association between Epstein-Barr virus and classic Hodgkins lymphoma in adult patients from Ceará (Brazil) by immunohistochemistry and in situ hybridization
Autor(a) principal: | |
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Data de Publicação: | 2006 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Jornal Brasileiro de Patologia e Medicina Laboratorial (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1676-24442006000300009 |
Resumo: | The prevalence of Epstein-Barr virus (EBV) in patients with classical Hodgkins lymphoma (CHL) is geographically variable. In the present study the prevalence of EBV in CHL was assessed in adult patients from Ceará, Brazil. Thirty-seven cases were immunohistochemically evaluated for EBV using latent membrane protein (LMP1) antibody and for EBV latency-associated RNA (EBER1) using in situ hybridization (ISH). Sex and age did not differ among patients as to the frequency of CHL. Nodular sclerosis was the predominant histological subtype. LMP1 was found in Reed-Sternberg cells in 67.5% of the cases whereas ISH detected EBER1 in 75.6%. Regarding histological subtypes EBV infection rates were not found statistically different in nodular sclerosis (NS) and mixed cellularity (MC) subtypes (p = 0.66). |
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Analysis of the association between Epstein-Barr virus and classic Hodgkins lymphoma in adult patients from Ceará (Brazil) by immunohistochemistry and in situ hybridizationClassical Hodgkins lymphomaEpstein-Barr virusLMP1EBER1The prevalence of Epstein-Barr virus (EBV) in patients with classical Hodgkins lymphoma (CHL) is geographically variable. In the present study the prevalence of EBV in CHL was assessed in adult patients from Ceará, Brazil. Thirty-seven cases were immunohistochemically evaluated for EBV using latent membrane protein (LMP1) antibody and for EBV latency-associated RNA (EBER1) using in situ hybridization (ISH). Sex and age did not differ among patients as to the frequency of CHL. Nodular sclerosis was the predominant histological subtype. LMP1 was found in Reed-Sternberg cells in 67.5% of the cases whereas ISH detected EBER1 in 75.6%. Regarding histological subtypes EBV infection rates were not found statistically different in nodular sclerosis (NS) and mixed cellularity (MC) subtypes (p = 0.66).Sociedade Brasileira de Patologia Clínica2006-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1676-24442006000300009Jornal Brasileiro de Patologia e Medicina Laboratorial v.42 n.3 2006reponame:Jornal Brasileiro de Patologia e Medicina Laboratorial (Online)instname:Sociedade Brasileira de Patologia (SBP)instacron:SBP10.1590/S1676-24442006000300009info:eu-repo/semantics/openAccessPinto,Marília TaumaturgoFerreira,Francisco Valdeci de AlmeidaPitombeira,Maria da SilvaMagalhães,Silvia Maria MeiraCosta,Clara Maria Bastos Eloy daLima Filho,Paulo Wagner LinharesFérrer,Renata Praciano CorreiaAguiar,Andrei Levine Porfírio deRocha Filho,Francisco Dárioeng2006-08-04T00:00:00Zoai:scielo:S1676-24442006000300009Revistahttp://www.scielo.br/jbpmlhttps://old.scielo.br/oai/scielo-oai.php||jbpml@sbpc.org.br1678-47741676-2444opendoar:2006-08-04T00:00Jornal Brasileiro de Patologia e Medicina Laboratorial (Online) - Sociedade Brasileira de Patologia (SBP)false |
dc.title.none.fl_str_mv |
Analysis of the association between Epstein-Barr virus and classic Hodgkins lymphoma in adult patients from Ceará (Brazil) by immunohistochemistry and in situ hybridization |
title |
Analysis of the association between Epstein-Barr virus and classic Hodgkins lymphoma in adult patients from Ceará (Brazil) by immunohistochemistry and in situ hybridization |
spellingShingle |
Analysis of the association between Epstein-Barr virus and classic Hodgkins lymphoma in adult patients from Ceará (Brazil) by immunohistochemistry and in situ hybridization Pinto,Marília Taumaturgo Classical Hodgkins lymphoma Epstein-Barr virus LMP1 EBER1 |
title_short |
Analysis of the association between Epstein-Barr virus and classic Hodgkins lymphoma in adult patients from Ceará (Brazil) by immunohistochemistry and in situ hybridization |
title_full |
Analysis of the association between Epstein-Barr virus and classic Hodgkins lymphoma in adult patients from Ceará (Brazil) by immunohistochemistry and in situ hybridization |
title_fullStr |
Analysis of the association between Epstein-Barr virus and classic Hodgkins lymphoma in adult patients from Ceará (Brazil) by immunohistochemistry and in situ hybridization |
title_full_unstemmed |
Analysis of the association between Epstein-Barr virus and classic Hodgkins lymphoma in adult patients from Ceará (Brazil) by immunohistochemistry and in situ hybridization |
title_sort |
Analysis of the association between Epstein-Barr virus and classic Hodgkins lymphoma in adult patients from Ceará (Brazil) by immunohistochemistry and in situ hybridization |
author |
Pinto,Marília Taumaturgo |
author_facet |
Pinto,Marília Taumaturgo Ferreira,Francisco Valdeci de Almeida Pitombeira,Maria da Silva Magalhães,Silvia Maria Meira Costa,Clara Maria Bastos Eloy da Lima Filho,Paulo Wagner Linhares Férrer,Renata Praciano Correia Aguiar,Andrei Levine Porfírio de Rocha Filho,Francisco Dário |
author_role |
author |
author2 |
Ferreira,Francisco Valdeci de Almeida Pitombeira,Maria da Silva Magalhães,Silvia Maria Meira Costa,Clara Maria Bastos Eloy da Lima Filho,Paulo Wagner Linhares Férrer,Renata Praciano Correia Aguiar,Andrei Levine Porfírio de Rocha Filho,Francisco Dário |
author2_role |
author author author author author author author author |
dc.contributor.author.fl_str_mv |
Pinto,Marília Taumaturgo Ferreira,Francisco Valdeci de Almeida Pitombeira,Maria da Silva Magalhães,Silvia Maria Meira Costa,Clara Maria Bastos Eloy da Lima Filho,Paulo Wagner Linhares Férrer,Renata Praciano Correia Aguiar,Andrei Levine Porfírio de Rocha Filho,Francisco Dário |
dc.subject.por.fl_str_mv |
Classical Hodgkins lymphoma Epstein-Barr virus LMP1 EBER1 |
topic |
Classical Hodgkins lymphoma Epstein-Barr virus LMP1 EBER1 |
description |
The prevalence of Epstein-Barr virus (EBV) in patients with classical Hodgkins lymphoma (CHL) is geographically variable. In the present study the prevalence of EBV in CHL was assessed in adult patients from Ceará, Brazil. Thirty-seven cases were immunohistochemically evaluated for EBV using latent membrane protein (LMP1) antibody and for EBV latency-associated RNA (EBER1) using in situ hybridization (ISH). Sex and age did not differ among patients as to the frequency of CHL. Nodular sclerosis was the predominant histological subtype. LMP1 was found in Reed-Sternberg cells in 67.5% of the cases whereas ISH detected EBER1 in 75.6%. Regarding histological subtypes EBV infection rates were not found statistically different in nodular sclerosis (NS) and mixed cellularity (MC) subtypes (p = 0.66). |
publishDate |
2006 |
dc.date.none.fl_str_mv |
2006-06-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1676-24442006000300009 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1676-24442006000300009 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S1676-24442006000300009 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Patologia Clínica |
publisher.none.fl_str_mv |
Sociedade Brasileira de Patologia Clínica |
dc.source.none.fl_str_mv |
Jornal Brasileiro de Patologia e Medicina Laboratorial v.42 n.3 2006 reponame:Jornal Brasileiro de Patologia e Medicina Laboratorial (Online) instname:Sociedade Brasileira de Patologia (SBP) instacron:SBP |
instname_str |
Sociedade Brasileira de Patologia (SBP) |
instacron_str |
SBP |
institution |
SBP |
reponame_str |
Jornal Brasileiro de Patologia e Medicina Laboratorial (Online) |
collection |
Jornal Brasileiro de Patologia e Medicina Laboratorial (Online) |
repository.name.fl_str_mv |
Jornal Brasileiro de Patologia e Medicina Laboratorial (Online) - Sociedade Brasileira de Patologia (SBP) |
repository.mail.fl_str_mv |
||jbpml@sbpc.org.br |
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1752122294042361856 |