Clinical difference between identical twins with sickle cell anemia

• Autor(a) principal: Laurentino,Marilia R.
• Data de Publicação: 2019
• Outros Autores: Almeida Filho,Tarcisio Paulo, Maia Filho,Pedro A., Nascimento,Francisco O. F., Advincula,Adlene F., Machado,Clarissa Maria G., Lemes,Romelia P G.
• Tipo de documento: Relatório
• Idioma: eng
• Título da fonte: Jornal Brasileiro de Patologia e Medicina Laboratorial (Online)
• Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1676-24442019000600705
• topic: sickle cell anemia; leg ulcer; monozygotic twins; genetics; hydroxyurea

ABSTRACT Sickle cell anemia (SCA) is a genetic disease that causes important clinical manifestations due to chronic hemolysis and vascular occlusion. The aim of this study was to report a rare case of monozygotic twins diagnosed with SCA, presenting a different clinical characteristic. An interview with the patients was carried out and the medical records were consulted. One patient has a history of malleolar ulcer in the left back, while the other does not. Both patients used hydroxyurea at the same dosage. This study shows that SCA presents, in addition to genetic factors, non-genetic factors involved in the severity of the disease and its clinical manifestations. Studies are needed that may contribute to the understanding of the clinical heterogeneity of SCA.