Inclusion-body myositis: a difficult diagnosis?

Detalhes bibliográficos
Autor(a) principal: Correia,Carolina da Cunha
Data de Publicação: 2014
Outros Autores: Magalhães,Maria Clara de Oliveira, Barbosa,Pedro Lucas de Mendonça, Campos,Eliene Dutra, Zanoteli,Edmar
Tipo de documento: Relatório
Idioma: eng
Título da fonte: Jornal Brasileiro de Patologia e Medicina Laboratorial (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1676-24442014000500364
Resumo: Sporadic inclusion-body myositis (IBM) is the most common myopathy in individuals over 55 years of age. However, in many cases, the diagnosis is neglected. Its main findings include progressive muscle weakness, normal or low levels of serum creatine kinase, and the absence of a response to immunosuppression. Muscle biopsy shows inflammatory reaction in association with degenerative changes of the muscle fibers. We report a typical case of IBM, in which diagnosis was possible only after three muscle biopsies. The challenges to confirm histological diagnosis and the caution to avoid repeating tests are discussed.
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spelling Inclusion-body myositis: a difficult diagnosis?skeletal musclemyositismuscular diseasesbiopsymuscle weakness.Sporadic inclusion-body myositis (IBM) is the most common myopathy in individuals over 55 years of age. However, in many cases, the diagnosis is neglected. Its main findings include progressive muscle weakness, normal or low levels of serum creatine kinase, and the absence of a response to immunosuppression. Muscle biopsy shows inflammatory reaction in association with degenerative changes of the muscle fibers. We report a typical case of IBM, in which diagnosis was possible only after three muscle biopsies. The challenges to confirm histological diagnosis and the caution to avoid repeating tests are discussed.Sociedade Brasileira de Patologia Clínica2014-10-01info:eu-repo/semantics/reportinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1676-24442014000500364Jornal Brasileiro de Patologia e Medicina Laboratorial v.50 n.5 2014reponame:Jornal Brasileiro de Patologia e Medicina Laboratorial (Online)instname:Sociedade Brasileira de Patologia (SBP)instacron:SBP10.5935/1676-2444.20140041info:eu-repo/semantics/openAccessCorreia,Carolina da CunhaMagalhães,Maria Clara de OliveiraBarbosa,Pedro Lucas de MendonçaCampos,Eliene DutraZanoteli,Edmareng2014-12-09T00:00:00Zoai:scielo:S1676-24442014000500364Revistahttp://www.scielo.br/jbpmlhttps://old.scielo.br/oai/scielo-oai.php||jbpml@sbpc.org.br1678-47741676-2444opendoar:2014-12-09T00:00Jornal Brasileiro de Patologia e Medicina Laboratorial (Online) - Sociedade Brasileira de Patologia (SBP)false
dc.title.none.fl_str_mv Inclusion-body myositis: a difficult diagnosis?
title Inclusion-body myositis: a difficult diagnosis?
spellingShingle Inclusion-body myositis: a difficult diagnosis?
Correia,Carolina da Cunha
skeletal muscle
myositis
muscular diseases
biopsy
muscle weakness.
title_short Inclusion-body myositis: a difficult diagnosis?
title_full Inclusion-body myositis: a difficult diagnosis?
title_fullStr Inclusion-body myositis: a difficult diagnosis?
title_full_unstemmed Inclusion-body myositis: a difficult diagnosis?
title_sort Inclusion-body myositis: a difficult diagnosis?
author Correia,Carolina da Cunha
author_facet Correia,Carolina da Cunha
Magalhães,Maria Clara de Oliveira
Barbosa,Pedro Lucas de Mendonça
Campos,Eliene Dutra
Zanoteli,Edmar
author_role author
author2 Magalhães,Maria Clara de Oliveira
Barbosa,Pedro Lucas de Mendonça
Campos,Eliene Dutra
Zanoteli,Edmar
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Correia,Carolina da Cunha
Magalhães,Maria Clara de Oliveira
Barbosa,Pedro Lucas de Mendonça
Campos,Eliene Dutra
Zanoteli,Edmar
dc.subject.por.fl_str_mv skeletal muscle
myositis
muscular diseases
biopsy
muscle weakness.
topic skeletal muscle
myositis
muscular diseases
biopsy
muscle weakness.
description Sporadic inclusion-body myositis (IBM) is the most common myopathy in individuals over 55 years of age. However, in many cases, the diagnosis is neglected. Its main findings include progressive muscle weakness, normal or low levels of serum creatine kinase, and the absence of a response to immunosuppression. Muscle biopsy shows inflammatory reaction in association with degenerative changes of the muscle fibers. We report a typical case of IBM, in which diagnosis was possible only after three muscle biopsies. The challenges to confirm histological diagnosis and the caution to avoid repeating tests are discussed.
publishDate 2014
dc.date.none.fl_str_mv 2014-10-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/report
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format report
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1676-24442014000500364
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dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.5935/1676-2444.20140041
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv
Sociedade Brasileira de Patologia Clínica
publisher.none.fl_str_mv
Sociedade Brasileira de Patologia Clínica
dc.source.none.fl_str_mv Jornal Brasileiro de Patologia e Medicina Laboratorial v.50 n.5 2014
reponame:Jornal Brasileiro de Patologia e Medicina Laboratorial (Online)
instname:Sociedade Brasileira de Patologia (SBP)
instacron:SBP
instname_str Sociedade Brasileira de Patologia (SBP)
instacron_str SBP
institution SBP
reponame_str Jornal Brasileiro de Patologia e Medicina Laboratorial (Online)
collection Jornal Brasileiro de Patologia e Medicina Laboratorial (Online)
repository.name.fl_str_mv Jornal Brasileiro de Patologia e Medicina Laboratorial (Online) - Sociedade Brasileira de Patologia (SBP)
repository.mail.fl_str_mv ||jbpml@sbpc.org.br
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