The importance of immunophenotyping by flow cytometry in distinction between hematogones and B lymphoblasts
Autor(a) principal: | |
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Data de Publicação: | 2015 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Jornal Brasileiro de Patologia e Medicina Laboratorial (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1676-24442015000100007 |
Resumo: | Hematogones are normal B-lineage lymphoid precursors in the bone marrow. B lymphoblasts are immature neoplastic cells present in patients with precursor B-cell acute lymphoblastic leukemia (B-ALL). Hematogones and B lymphoblasts share characteristics, such as morphological similarity often indistinct and expression of the same antigens in immunophenotypic analysis. Increased numbers of hematogones in patients with B-ALL during regeneration of bone marrow after treatment for leukemia, in cases of disease relapse or marrow transplantation, may be subject to questions about the nature and prognosis of this immature cell. This article presents information about the morphological and immunophenotypic characteristics of B lymphoid precursors and verifies the relevance of immunophenotyping by flow cytometry (FC) in the distinction between those cells. This differentiation is essential to establish a correct prognosis and assist in medical decision about the most appropriate therapeutic scheme. |
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The importance of immunophenotyping by flow cytometry in distinction between hematogones and B lymphoblastshematogonesB lymphoblastsacute lymphoblastic leukemiaflow cytometryimmunophenotypingHematogones are normal B-lineage lymphoid precursors in the bone marrow. B lymphoblasts are immature neoplastic cells present in patients with precursor B-cell acute lymphoblastic leukemia (B-ALL). Hematogones and B lymphoblasts share characteristics, such as morphological similarity often indistinct and expression of the same antigens in immunophenotypic analysis. Increased numbers of hematogones in patients with B-ALL during regeneration of bone marrow after treatment for leukemia, in cases of disease relapse or marrow transplantation, may be subject to questions about the nature and prognosis of this immature cell. This article presents information about the morphological and immunophenotypic characteristics of B lymphoid precursors and verifies the relevance of immunophenotyping by flow cytometry (FC) in the distinction between those cells. This differentiation is essential to establish a correct prognosis and assist in medical decision about the most appropriate therapeutic scheme.Sociedade Brasileira de Patologia Clínica2015-02-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1676-24442015000100007Jornal Brasileiro de Patologia e Medicina Laboratorial v.51 n.1 2015reponame:Jornal Brasileiro de Patologia e Medicina Laboratorial (Online)instname:Sociedade Brasileira de Patologia (SBP)instacron:SBP10.5935/1676-2444.20150002info:eu-repo/semantics/openAccessWohlfahrt,Aline B.Hannel,LauraOliveira,Liliane Z.Soares,Pâmela B.Silva,José Edson P.eng2015-05-14T00:00:00Zoai:scielo:S1676-24442015000100007Revistahttp://www.scielo.br/jbpmlhttps://old.scielo.br/oai/scielo-oai.php||jbpml@sbpc.org.br1678-47741676-2444opendoar:2015-05-14T00:00Jornal Brasileiro de Patologia e Medicina Laboratorial (Online) - Sociedade Brasileira de Patologia (SBP)false |
dc.title.none.fl_str_mv |
The importance of immunophenotyping by flow cytometry in distinction between hematogones and B lymphoblasts |
title |
The importance of immunophenotyping by flow cytometry in distinction between hematogones and B lymphoblasts |
spellingShingle |
The importance of immunophenotyping by flow cytometry in distinction between hematogones and B lymphoblasts Wohlfahrt,Aline B. hematogones B lymphoblasts acute lymphoblastic leukemia flow cytometry immunophenotyping |
title_short |
The importance of immunophenotyping by flow cytometry in distinction between hematogones and B lymphoblasts |
title_full |
The importance of immunophenotyping by flow cytometry in distinction between hematogones and B lymphoblasts |
title_fullStr |
The importance of immunophenotyping by flow cytometry in distinction between hematogones and B lymphoblasts |
title_full_unstemmed |
The importance of immunophenotyping by flow cytometry in distinction between hematogones and B lymphoblasts |
title_sort |
The importance of immunophenotyping by flow cytometry in distinction between hematogones and B lymphoblasts |
author |
Wohlfahrt,Aline B. |
author_facet |
Wohlfahrt,Aline B. Hannel,Laura Oliveira,Liliane Z. Soares,Pâmela B. Silva,José Edson P. |
author_role |
author |
author2 |
Hannel,Laura Oliveira,Liliane Z. Soares,Pâmela B. Silva,José Edson P. |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Wohlfahrt,Aline B. Hannel,Laura Oliveira,Liliane Z. Soares,Pâmela B. Silva,José Edson P. |
dc.subject.por.fl_str_mv |
hematogones B lymphoblasts acute lymphoblastic leukemia flow cytometry immunophenotyping |
topic |
hematogones B lymphoblasts acute lymphoblastic leukemia flow cytometry immunophenotyping |
description |
Hematogones are normal B-lineage lymphoid precursors in the bone marrow. B lymphoblasts are immature neoplastic cells present in patients with precursor B-cell acute lymphoblastic leukemia (B-ALL). Hematogones and B lymphoblasts share characteristics, such as morphological similarity often indistinct and expression of the same antigens in immunophenotypic analysis. Increased numbers of hematogones in patients with B-ALL during regeneration of bone marrow after treatment for leukemia, in cases of disease relapse or marrow transplantation, may be subject to questions about the nature and prognosis of this immature cell. This article presents information about the morphological and immunophenotypic characteristics of B lymphoid precursors and verifies the relevance of immunophenotyping by flow cytometry (FC) in the distinction between those cells. This differentiation is essential to establish a correct prognosis and assist in medical decision about the most appropriate therapeutic scheme. |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015-02-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1676-24442015000100007 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1676-24442015000100007 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.5935/1676-2444.20150002 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Patologia Clínica |
publisher.none.fl_str_mv |
Sociedade Brasileira de Patologia Clínica |
dc.source.none.fl_str_mv |
Jornal Brasileiro de Patologia e Medicina Laboratorial v.51 n.1 2015 reponame:Jornal Brasileiro de Patologia e Medicina Laboratorial (Online) instname:Sociedade Brasileira de Patologia (SBP) instacron:SBP |
instname_str |
Sociedade Brasileira de Patologia (SBP) |
instacron_str |
SBP |
institution |
SBP |
reponame_str |
Jornal Brasileiro de Patologia e Medicina Laboratorial (Online) |
collection |
Jornal Brasileiro de Patologia e Medicina Laboratorial (Online) |
repository.name.fl_str_mv |
Jornal Brasileiro de Patologia e Medicina Laboratorial (Online) - Sociedade Brasileira de Patologia (SBP) |
repository.mail.fl_str_mv |
||jbpml@sbpc.org.br |
_version_ |
1752122296251711488 |