Immunological deficiencies: more frequent than they seem to be
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Jornal de Pediatria (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0021-75572021000700049 |
Resumo: | Abstract Objective: A review article was carried out, addressing the clinical and epidemiological characteristics of immune system deficiencies, which are associated with or predispose to recurrent infectious processes, autoimmune diseases, auto inflammatory diseases, or neoplasms, and which are classified as inborn errors of immunity (IEI) and secondary immunodeficiencies (SID). Emphasis was placed on the classification of the main signs and symptoms for each organ and system, which will serve as warning signs, to guide the pediatrician in the investigation of the main IEI. In addition, the main secondary changes in the immune system triggered by infections (with emphasis on COVID-19), drugs, chronic diseases, metabolic and nutritional disorders were identified. Sources of data: This review included articles published in the last five years and that were identified in the MEDLINE platform (PubMed). Summary of findings: The recurrence of infectious processes, associated with the severity of the condition and/or unusual profile of the infectious agent, always related to the age range of symptom onset, are the most important findings for suspected diagnosis. Conclusions: Considering this scenario, immunity disorders should be part of the investigation carried out by the general pediatrician, whether they are the innate errors of immunity (primary immunodeficiencies) or secondary immunodeficiencies, so that the diagnosis is attained as early as possible and therapeutic measures are implemented, reducing the morbidity and mortality of these patients. |
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Immunological deficiencies: more frequent than they seem to bePrimary immunodeficiency disordersImmunodeficiency disordersClassificationEpidemiologyCOVID-19SARS-CoV-2Abstract Objective: A review article was carried out, addressing the clinical and epidemiological characteristics of immune system deficiencies, which are associated with or predispose to recurrent infectious processes, autoimmune diseases, auto inflammatory diseases, or neoplasms, and which are classified as inborn errors of immunity (IEI) and secondary immunodeficiencies (SID). Emphasis was placed on the classification of the main signs and symptoms for each organ and system, which will serve as warning signs, to guide the pediatrician in the investigation of the main IEI. In addition, the main secondary changes in the immune system triggered by infections (with emphasis on COVID-19), drugs, chronic diseases, metabolic and nutritional disorders were identified. Sources of data: This review included articles published in the last five years and that were identified in the MEDLINE platform (PubMed). Summary of findings: The recurrence of infectious processes, associated with the severity of the condition and/or unusual profile of the infectious agent, always related to the age range of symptom onset, are the most important findings for suspected diagnosis. Conclusions: Considering this scenario, immunity disorders should be part of the investigation carried out by the general pediatrician, whether they are the innate errors of immunity (primary immunodeficiencies) or secondary immunodeficiencies, so that the diagnosis is attained as early as possible and therapeutic measures are implemented, reducing the morbidity and mortality of these patients.Sociedade Brasileira de Pediatria2021-04-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0021-75572021000700049Jornal de Pediatria v.97 suppl.1 2021reponame:Jornal de Pediatria (Online)instname:Sociedade Brasileira de Pediatria (SBP)instacron:SBPE10.1016/j.jped.2020.10.009info:eu-repo/semantics/openAccessBarreto,Irma Cecília Douglas PaesBarreto,Bruno Acatauassú PaesCavalcante,Erica Gomes do NascimentoCondino Neto,Antonioeng2021-04-22T00:00:00Zoai:scielo:S0021-75572021000700049Revistahttp://www.jped.com.br/https://old.scielo.br/oai/scielo-oai.php||jped@jped.com.br1678-47820021-7557opendoar:2021-04-22T00:00Jornal de Pediatria (Online) - Sociedade Brasileira de Pediatria (SBP)false |
dc.title.none.fl_str_mv |
Immunological deficiencies: more frequent than they seem to be |
title |
Immunological deficiencies: more frequent than they seem to be |
spellingShingle |
Immunological deficiencies: more frequent than they seem to be Barreto,Irma Cecília Douglas Paes Primary immunodeficiency disorders Immunodeficiency disorders Classification Epidemiology COVID-19 SARS-CoV-2 |
title_short |
Immunological deficiencies: more frequent than they seem to be |
title_full |
Immunological deficiencies: more frequent than they seem to be |
title_fullStr |
Immunological deficiencies: more frequent than they seem to be |
title_full_unstemmed |
Immunological deficiencies: more frequent than they seem to be |
title_sort |
Immunological deficiencies: more frequent than they seem to be |
author |
Barreto,Irma Cecília Douglas Paes |
author_facet |
Barreto,Irma Cecília Douglas Paes Barreto,Bruno Acatauassú Paes Cavalcante,Erica Gomes do Nascimento Condino Neto,Antonio |
author_role |
author |
author2 |
Barreto,Bruno Acatauassú Paes Cavalcante,Erica Gomes do Nascimento Condino Neto,Antonio |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Barreto,Irma Cecília Douglas Paes Barreto,Bruno Acatauassú Paes Cavalcante,Erica Gomes do Nascimento Condino Neto,Antonio |
dc.subject.por.fl_str_mv |
Primary immunodeficiency disorders Immunodeficiency disorders Classification Epidemiology COVID-19 SARS-CoV-2 |
topic |
Primary immunodeficiency disorders Immunodeficiency disorders Classification Epidemiology COVID-19 SARS-CoV-2 |
description |
Abstract Objective: A review article was carried out, addressing the clinical and epidemiological characteristics of immune system deficiencies, which are associated with or predispose to recurrent infectious processes, autoimmune diseases, auto inflammatory diseases, or neoplasms, and which are classified as inborn errors of immunity (IEI) and secondary immunodeficiencies (SID). Emphasis was placed on the classification of the main signs and symptoms for each organ and system, which will serve as warning signs, to guide the pediatrician in the investigation of the main IEI. In addition, the main secondary changes in the immune system triggered by infections (with emphasis on COVID-19), drugs, chronic diseases, metabolic and nutritional disorders were identified. Sources of data: This review included articles published in the last five years and that were identified in the MEDLINE platform (PubMed). Summary of findings: The recurrence of infectious processes, associated with the severity of the condition and/or unusual profile of the infectious agent, always related to the age range of symptom onset, are the most important findings for suspected diagnosis. Conclusions: Considering this scenario, immunity disorders should be part of the investigation carried out by the general pediatrician, whether they are the innate errors of immunity (primary immunodeficiencies) or secondary immunodeficiencies, so that the diagnosis is attained as early as possible and therapeutic measures are implemented, reducing the morbidity and mortality of these patients. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-04-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0021-75572021000700049 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0021-75572021000700049 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1016/j.jped.2020.10.009 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Pediatria |
publisher.none.fl_str_mv |
Sociedade Brasileira de Pediatria |
dc.source.none.fl_str_mv |
Jornal de Pediatria v.97 suppl.1 2021 reponame:Jornal de Pediatria (Online) instname:Sociedade Brasileira de Pediatria (SBP) instacron:SBPE |
instname_str |
Sociedade Brasileira de Pediatria (SBP) |
instacron_str |
SBPE |
institution |
SBPE |
reponame_str |
Jornal de Pediatria (Online) |
collection |
Jornal de Pediatria (Online) |
repository.name.fl_str_mv |
Jornal de Pediatria (Online) - Sociedade Brasileira de Pediatria (SBP) |
repository.mail.fl_str_mv |
||jped@jped.com.br |
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1752122323188580352 |