Evaluation of nonalcoholic fatty liver disease using magnetic resonance in obese children and adolescents

Detalhes bibliográficos
Autor(a) principal: Benetolo,Patrícia O.
Data de Publicação: 2019
Outros Autores: Fernandes,Maria I.M., Ciampo,Ieda R.L. Del, Elias-Junior,Jorge, Sawamura,Regina
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Jornal de Pediatria (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0021-75572019000100034
Resumo: Abstract Objective: To determine the frequency of nonalcoholic fatty liver disease using nuclear magnetic resonance as a noninvasive method. Methodology: This was a cross-sectional study conducted on 50 children and adolescents followed up at an outpatient obesity clinic. The subjects were submitted to physical examination, laboratory tests (transaminases, liver function tests, lipid profile, glycemia, and basal insulin) and abdominal nuclear magnetic resonance (calculation of hepatic, visceral, and subcutaneous fat). Results: Nonalcoholic fatty liver disease was diagnosed in 14 (28%) participants, as a severe condition in eight (percent fat >18%), and as non-severe in four (percent fat from 9% to 18%). Fatty liver was associated with male gender, triglycerides, AST, ALT, AST/ALT ratio, and acanthosis nigricans. Homeostasis model assessment of insulin resistance and metabolic syndrome did not show an association with fatty liver. Conclusion: The frequency of nonalcoholic fatty liver disease in the present population of children and adolescents was lower than that reported in the international literature. It is suggested that nuclear magnetic resonance is an imaging exam that can be applied to children and adolescents, thus representing an effective noninvasive tool for the diagnosis of nonalcoholic fatty liver disease in this age range. However, further national multicenter studies with longitudinal design are needed for a better analysis of the correlation between nonalcoholic fatty liver disease and its risk factors, as well as its consequences.
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spelling Evaluation of nonalcoholic fatty liver disease using magnetic resonance in obese children and adolescentsNonalcoholic fatty liver diseaseHepatic steatosisNuclear magnetic resonanceObese children and adolescentsAbstract Objective: To determine the frequency of nonalcoholic fatty liver disease using nuclear magnetic resonance as a noninvasive method. Methodology: This was a cross-sectional study conducted on 50 children and adolescents followed up at an outpatient obesity clinic. The subjects were submitted to physical examination, laboratory tests (transaminases, liver function tests, lipid profile, glycemia, and basal insulin) and abdominal nuclear magnetic resonance (calculation of hepatic, visceral, and subcutaneous fat). Results: Nonalcoholic fatty liver disease was diagnosed in 14 (28%) participants, as a severe condition in eight (percent fat >18%), and as non-severe in four (percent fat from 9% to 18%). Fatty liver was associated with male gender, triglycerides, AST, ALT, AST/ALT ratio, and acanthosis nigricans. Homeostasis model assessment of insulin resistance and metabolic syndrome did not show an association with fatty liver. Conclusion: The frequency of nonalcoholic fatty liver disease in the present population of children and adolescents was lower than that reported in the international literature. It is suggested that nuclear magnetic resonance is an imaging exam that can be applied to children and adolescents, thus representing an effective noninvasive tool for the diagnosis of nonalcoholic fatty liver disease in this age range. However, further national multicenter studies with longitudinal design are needed for a better analysis of the correlation between nonalcoholic fatty liver disease and its risk factors, as well as its consequences.Sociedade Brasileira de Pediatria2019-02-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0021-75572019000100034Jornal de Pediatria v.95 n.1 2019reponame:Jornal de Pediatria (Online)instname:Sociedade Brasileira de Pediatria (SBP)instacron:SBPE10.1016/j.jped.2017.12.010info:eu-repo/semantics/openAccessBenetolo,Patrícia O.Fernandes,Maria I.M.Ciampo,Ieda R.L. DelElias-Junior,JorgeSawamura,Reginaeng2019-02-05T00:00:00Zoai:scielo:S0021-75572019000100034Revistahttp://www.jped.com.br/https://old.scielo.br/oai/scielo-oai.php||jped@jped.com.br1678-47820021-7557opendoar:2019-02-05T00:00Jornal de Pediatria (Online) - Sociedade Brasileira de Pediatria (SBP)false
dc.title.none.fl_str_mv Evaluation of nonalcoholic fatty liver disease using magnetic resonance in obese children and adolescents
title Evaluation of nonalcoholic fatty liver disease using magnetic resonance in obese children and adolescents
spellingShingle Evaluation of nonalcoholic fatty liver disease using magnetic resonance in obese children and adolescents
Benetolo,Patrícia O.
Nonalcoholic fatty liver disease
Hepatic steatosis
Nuclear magnetic resonance
Obese children and adolescents
title_short Evaluation of nonalcoholic fatty liver disease using magnetic resonance in obese children and adolescents
title_full Evaluation of nonalcoholic fatty liver disease using magnetic resonance in obese children and adolescents
title_fullStr Evaluation of nonalcoholic fatty liver disease using magnetic resonance in obese children and adolescents
title_full_unstemmed Evaluation of nonalcoholic fatty liver disease using magnetic resonance in obese children and adolescents
title_sort Evaluation of nonalcoholic fatty liver disease using magnetic resonance in obese children and adolescents
author Benetolo,Patrícia O.
author_facet Benetolo,Patrícia O.
Fernandes,Maria I.M.
Ciampo,Ieda R.L. Del
Elias-Junior,Jorge
Sawamura,Regina
author_role author
author2 Fernandes,Maria I.M.
Ciampo,Ieda R.L. Del
Elias-Junior,Jorge
Sawamura,Regina
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Benetolo,Patrícia O.
Fernandes,Maria I.M.
Ciampo,Ieda R.L. Del
Elias-Junior,Jorge
Sawamura,Regina
dc.subject.por.fl_str_mv Nonalcoholic fatty liver disease
Hepatic steatosis
Nuclear magnetic resonance
Obese children and adolescents
topic Nonalcoholic fatty liver disease
Hepatic steatosis
Nuclear magnetic resonance
Obese children and adolescents
description Abstract Objective: To determine the frequency of nonalcoholic fatty liver disease using nuclear magnetic resonance as a noninvasive method. Methodology: This was a cross-sectional study conducted on 50 children and adolescents followed up at an outpatient obesity clinic. The subjects were submitted to physical examination, laboratory tests (transaminases, liver function tests, lipid profile, glycemia, and basal insulin) and abdominal nuclear magnetic resonance (calculation of hepatic, visceral, and subcutaneous fat). Results: Nonalcoholic fatty liver disease was diagnosed in 14 (28%) participants, as a severe condition in eight (percent fat >18%), and as non-severe in four (percent fat from 9% to 18%). Fatty liver was associated with male gender, triglycerides, AST, ALT, AST/ALT ratio, and acanthosis nigricans. Homeostasis model assessment of insulin resistance and metabolic syndrome did not show an association with fatty liver. Conclusion: The frequency of nonalcoholic fatty liver disease in the present population of children and adolescents was lower than that reported in the international literature. It is suggested that nuclear magnetic resonance is an imaging exam that can be applied to children and adolescents, thus representing an effective noninvasive tool for the diagnosis of nonalcoholic fatty liver disease in this age range. However, further national multicenter studies with longitudinal design are needed for a better analysis of the correlation between nonalcoholic fatty liver disease and its risk factors, as well as its consequences.
publishDate 2019
dc.date.none.fl_str_mv 2019-02-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0021-75572019000100034
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dc.language.iso.fl_str_mv eng
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dc.relation.none.fl_str_mv 10.1016/j.jped.2017.12.010
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dc.publisher.none.fl_str_mv Sociedade Brasileira de Pediatria
publisher.none.fl_str_mv Sociedade Brasileira de Pediatria
dc.source.none.fl_str_mv Jornal de Pediatria v.95 n.1 2019
reponame:Jornal de Pediatria (Online)
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