One-year adolescent bone mineral density and bone formation marker changes through the use or lack of use of combined hormonal contraceptives
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Jornal de Pediatria (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0021-75572019000600567 |
Resumo: | Abstract Objective: The objective of this study was to evaluate the effects of two low-dose combined oral contraceptives on bone metabolism in adolescents for one year. Methods: This was a quasi-experimental study. The adolescents were divided into three groups: oral contraceptives 1 (n = 42) (20 µg EE/150 µg desogestrel), oral contraceptives 2 (n = 66) (30 µg EE/3 mg drospirenone), and a control group (n = 70). Adolescents underwent anthropometric assessment and densitometry (dual-energy X-ray). Bone age and bone formation markers (osteocalcin and bone alkaline phosphatase) were evaluated. The oral contraceptives users were evaluated again after 12 months. Linear regression analysis was used to indirectly study the effect of each additional year of chronological age on anthropometric and densitometric variables as well as on bone markers in the control group. Results: At study entry, no significant differences were observed between the oral contraceptives 1, oral contraceptives 2, and controls in the analyzed variables. Linear regression analysis showed an increase in bone mineral density and bone mineral content for each additional year. There was a significant reduction in bone alkaline phosphatase levels; no significant difference was observed for osteocalcin in control individuals. Comparison of dual-energy X-ray variables at baseline and after one year showed no significant differences in the oral contraceptives 1 or oral contraceptives 2 groups. A significant reduction in bone alkaline phosphatase and osteocalcin levels was observed in both the oral contraceptives 1 and oral contraceptives 2 groups. Conclusion: Adolescent women gain peak bone mass during this phase of life. Two low-dose combined oral hormonal contraceptives were associated with lower bone gain and lower bone formation markers than in untreated controls. |
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Jornal de Pediatria (Online) |
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One-year adolescent bone mineral density and bone formation marker changes through the use or lack of use of combined hormonal contraceptivesAdolescentsOral contraceptivesBone densityOsteocalcinBone remodelingProspective studyAbstract Objective: The objective of this study was to evaluate the effects of two low-dose combined oral contraceptives on bone metabolism in adolescents for one year. Methods: This was a quasi-experimental study. The adolescents were divided into three groups: oral contraceptives 1 (n = 42) (20 µg EE/150 µg desogestrel), oral contraceptives 2 (n = 66) (30 µg EE/3 mg drospirenone), and a control group (n = 70). Adolescents underwent anthropometric assessment and densitometry (dual-energy X-ray). Bone age and bone formation markers (osteocalcin and bone alkaline phosphatase) were evaluated. The oral contraceptives users were evaluated again after 12 months. Linear regression analysis was used to indirectly study the effect of each additional year of chronological age on anthropometric and densitometric variables as well as on bone markers in the control group. Results: At study entry, no significant differences were observed between the oral contraceptives 1, oral contraceptives 2, and controls in the analyzed variables. Linear regression analysis showed an increase in bone mineral density and bone mineral content for each additional year. There was a significant reduction in bone alkaline phosphatase levels; no significant difference was observed for osteocalcin in control individuals. Comparison of dual-energy X-ray variables at baseline and after one year showed no significant differences in the oral contraceptives 1 or oral contraceptives 2 groups. A significant reduction in bone alkaline phosphatase and osteocalcin levels was observed in both the oral contraceptives 1 and oral contraceptives 2 groups. Conclusion: Adolescent women gain peak bone mass during this phase of life. Two low-dose combined oral hormonal contraceptives were associated with lower bone gain and lower bone formation markers than in untreated controls.Sociedade Brasileira de Pediatria2019-09-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0021-75572019000600567Jornal de Pediatria v.95 n.5 2019reponame:Jornal de Pediatria (Online)instname:Sociedade Brasileira de Pediatria (SBP)instacron:SBPE10.1016/j.jped.2018.05.011info:eu-repo/semantics/openAccessRizzo,Anapaula da Conceição BisiGoldberg,Tamara Beres LedererBiason,Talita PoliKurokawa,Cilmery SuemiSilva,Carla Cristiane daCorrente,José EduardoNunes,Helio Rubens Carvalhoeng2019-10-23T00:00:00Zoai:scielo:S0021-75572019000600567Revistahttp://www.jped.com.br/https://old.scielo.br/oai/scielo-oai.php||jped@jped.com.br1678-47820021-7557opendoar:2019-10-23T00:00Jornal de Pediatria (Online) - Sociedade Brasileira de Pediatria (SBP)false |
dc.title.none.fl_str_mv |
One-year adolescent bone mineral density and bone formation marker changes through the use or lack of use of combined hormonal contraceptives |
title |
One-year adolescent bone mineral density and bone formation marker changes through the use or lack of use of combined hormonal contraceptives |
spellingShingle |
One-year adolescent bone mineral density and bone formation marker changes through the use or lack of use of combined hormonal contraceptives Rizzo,Anapaula da Conceição Bisi Adolescents Oral contraceptives Bone density Osteocalcin Bone remodeling Prospective study |
title_short |
One-year adolescent bone mineral density and bone formation marker changes through the use or lack of use of combined hormonal contraceptives |
title_full |
One-year adolescent bone mineral density and bone formation marker changes through the use or lack of use of combined hormonal contraceptives |
title_fullStr |
One-year adolescent bone mineral density and bone formation marker changes through the use or lack of use of combined hormonal contraceptives |
title_full_unstemmed |
One-year adolescent bone mineral density and bone formation marker changes through the use or lack of use of combined hormonal contraceptives |
title_sort |
One-year adolescent bone mineral density and bone formation marker changes through the use or lack of use of combined hormonal contraceptives |
author |
Rizzo,Anapaula da Conceição Bisi |
author_facet |
Rizzo,Anapaula da Conceição Bisi Goldberg,Tamara Beres Lederer Biason,Talita Poli Kurokawa,Cilmery Suemi Silva,Carla Cristiane da Corrente,José Eduardo Nunes,Helio Rubens Carvalho |
author_role |
author |
author2 |
Goldberg,Tamara Beres Lederer Biason,Talita Poli Kurokawa,Cilmery Suemi Silva,Carla Cristiane da Corrente,José Eduardo Nunes,Helio Rubens Carvalho |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Rizzo,Anapaula da Conceição Bisi Goldberg,Tamara Beres Lederer Biason,Talita Poli Kurokawa,Cilmery Suemi Silva,Carla Cristiane da Corrente,José Eduardo Nunes,Helio Rubens Carvalho |
dc.subject.por.fl_str_mv |
Adolescents Oral contraceptives Bone density Osteocalcin Bone remodeling Prospective study |
topic |
Adolescents Oral contraceptives Bone density Osteocalcin Bone remodeling Prospective study |
description |
Abstract Objective: The objective of this study was to evaluate the effects of two low-dose combined oral contraceptives on bone metabolism in adolescents for one year. Methods: This was a quasi-experimental study. The adolescents were divided into three groups: oral contraceptives 1 (n = 42) (20 µg EE/150 µg desogestrel), oral contraceptives 2 (n = 66) (30 µg EE/3 mg drospirenone), and a control group (n = 70). Adolescents underwent anthropometric assessment and densitometry (dual-energy X-ray). Bone age and bone formation markers (osteocalcin and bone alkaline phosphatase) were evaluated. The oral contraceptives users were evaluated again after 12 months. Linear regression analysis was used to indirectly study the effect of each additional year of chronological age on anthropometric and densitometric variables as well as on bone markers in the control group. Results: At study entry, no significant differences were observed between the oral contraceptives 1, oral contraceptives 2, and controls in the analyzed variables. Linear regression analysis showed an increase in bone mineral density and bone mineral content for each additional year. There was a significant reduction in bone alkaline phosphatase levels; no significant difference was observed for osteocalcin in control individuals. Comparison of dual-energy X-ray variables at baseline and after one year showed no significant differences in the oral contraceptives 1 or oral contraceptives 2 groups. A significant reduction in bone alkaline phosphatase and osteocalcin levels was observed in both the oral contraceptives 1 and oral contraceptives 2 groups. Conclusion: Adolescent women gain peak bone mass during this phase of life. Two low-dose combined oral hormonal contraceptives were associated with lower bone gain and lower bone formation markers than in untreated controls. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-09-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0021-75572019000600567 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0021-75572019000600567 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1016/j.jped.2018.05.011 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Pediatria |
publisher.none.fl_str_mv |
Sociedade Brasileira de Pediatria |
dc.source.none.fl_str_mv |
Jornal de Pediatria v.95 n.5 2019 reponame:Jornal de Pediatria (Online) instname:Sociedade Brasileira de Pediatria (SBP) instacron:SBPE |
instname_str |
Sociedade Brasileira de Pediatria (SBP) |
instacron_str |
SBPE |
institution |
SBPE |
reponame_str |
Jornal de Pediatria (Online) |
collection |
Jornal de Pediatria (Online) |
repository.name.fl_str_mv |
Jornal de Pediatria (Online) - Sociedade Brasileira de Pediatria (SBP) |
repository.mail.fl_str_mv |
||jped@jped.com.br |
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1752122321911414784 |