One-year adolescent bone mineral density and bone formation marker changes through the use or lack of use of combined hormonal contraceptives
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2018 |
| Outros Autores: | , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng por |
| Título da fonte: | Repositório Institucional da UNESP |
| Texto Completo: | http://dx.doi.org/10.1016/j.jped.2018.05.011 http://hdl.handle.net/11449/188424 |
Resumo: | Objective: The objective of this study was to evaluate the effects of two low-dose combined oral contraceptives on bone metabolism in adolescents for one year. Methods: This was a quasi-experimental study. The adolescents were divided into three groups: oral contraceptives 1 (n = 42) (20 μg EE/150 μg desogestrel), oral contraceptives 2 (n = 66) (30 μg EE/3 mg drospirenone), and a control group (n = 70). Adolescents underwent anthropometric assessment and densitometry (dual-energy X-ray). Bone age and bone formation markers (osteocalcin and bone alkaline phosphatase) were evaluated. The oral contraceptives users were evaluated again after 12 months. Linear regression analysis was used to indirectly study the effect of each additional year of chronological age on anthropometric and densitometric variables as well as on bone markers in the control group. Results: At study entry, no significant differences were observed between the oral contraceptives 1, oral contraceptives 2, and controls in the analyzed variables. Linear regression analysis showed an increase in bone mineral density and bone mineral content for each additional year. There was a significant reduction in bone alkaline phosphatase levels; no significant difference was observed for osteocalcin in control individuals. Comparison of dual-energy X-ray variables at baseline and after one year showed no significant differences in the oral contraceptives 1 or oral contraceptives 2 groups. A significant reduction in bone alkaline phosphatase and osteocalcin levels was observed in both the oral contraceptives 1 and oral contraceptives 2 groups. Conclusion: Adolescent women gain peak bone mass during this phase of life. Two low-dose combined oral hormonal contraceptives were associated with lower bone gain and lower bone formation markers than in untreated controls. |
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One-year adolescent bone mineral density and bone formation marker changes through the use or lack of use of combined hormonal contraceptivesAlterações na densidade mineral óssea e nos marcadores de formação óssea em adolescentes usuárias ou não de contraceptivos hormonais orais combinados por período de um anoAdolescentesAdolescentsBone densityBone remodelingContraceptivos oraisDensidade ósseaEstudo prospectivoOral contraceptivesOsteocalcinOsteocalcinaProspective studyRemodelação ósseaObjective: The objective of this study was to evaluate the effects of two low-dose combined oral contraceptives on bone metabolism in adolescents for one year. Methods: This was a quasi-experimental study. The adolescents were divided into three groups: oral contraceptives 1 (n = 42) (20 μg EE/150 μg desogestrel), oral contraceptives 2 (n = 66) (30 μg EE/3 mg drospirenone), and a control group (n = 70). Adolescents underwent anthropometric assessment and densitometry (dual-energy X-ray). Bone age and bone formation markers (osteocalcin and bone alkaline phosphatase) were evaluated. The oral contraceptives users were evaluated again after 12 months. Linear regression analysis was used to indirectly study the effect of each additional year of chronological age on anthropometric and densitometric variables as well as on bone markers in the control group. Results: At study entry, no significant differences were observed between the oral contraceptives 1, oral contraceptives 2, and controls in the analyzed variables. Linear regression analysis showed an increase in bone mineral density and bone mineral content for each additional year. There was a significant reduction in bone alkaline phosphatase levels; no significant difference was observed for osteocalcin in control individuals. Comparison of dual-energy X-ray variables at baseline and after one year showed no significant differences in the oral contraceptives 1 or oral contraceptives 2 groups. A significant reduction in bone alkaline phosphatase and osteocalcin levels was observed in both the oral contraceptives 1 and oral contraceptives 2 groups. Conclusion: Adolescent women gain peak bone mass during this phase of life. Two low-dose combined oral hormonal contraceptives were associated with lower bone gain and lower bone formation markers than in untreated controls.Objetivo: O objetivo deste estudo foi avaliar os efeitos de dois contraceptivos orais combinados de baixa dosagem por um ano sobre o metabolismo ósseo em adolescentes. Métodos: Este foi um estudo quase experimental. As adolescentes foram divididas em três grupos: contraceptivos orais 1 (n = 42) (20 μg de EE/150 μg de desogestrel), contraceptivos orais 2 (n = 66) (30 μg EE/3 mg de drospirenona) e grupo de controle (n = 70). As adolescentes foram submetidas à avaliação antropométrica e densitometria (raio-X de dupla energia). Foram avaliados a idade óssea e os marcadores de formação óssea (osteocalcina e fosfatase alcalina óssea). As usuárias de contraceptivos orais foram novamente avaliadas após 12 meses. A análise de regressão linear foi utilizada para estudar, indiretamente, o efeito de cada ano adicional da idade cronológica sobre as variáveis antropométricas e densitométricas e sobre os marcadores ósseos no grupo de controle. Resultados: No início do estudo, não foram observadas diferenças significativas nas variáveis analisadas entre as usuárias de contraceptivos orais 1, contraceptivos orais 2 e o grupo controle. A análise de regressão linear mostrou um aumento na densidade mineral óssea e no conteúdo mineral ósseo para cada ano adicional. Houve uma redução significativa nos níveis de fosfatase alcalina óssea e não foi observada nenhuma diferença significativa para osteocalcina nos indivíduos controles. A comparação das variáveis do raio-X de dupla energia no início e após um ano não mostrou nenhuma diferença significativa no grupo de contraceptivos orais 1 ou contraceptivos orais 2. Foi observada uma redução significativa nos níveis de fosfatase alcalina óssea e osteocalcina nos dois grupos contraceptivos orais 1 e contraceptivos orais 2. Conclusão: As mulheres adolescentes atingiram o pico de massa óssea durante essa fase da vida. Duas formulações de contraceptivos hormonais orais de baixa dosagem, após um ano de uso, se associaram a menor incremento na densidade mineral óssea e menor concentração de marcadores de formação óssea quando confrontados com resultados de adolescentes não usuárias de contraceptivos.Universidade Estadual Paulista (UNESP), Faculdade de Medicina de Botucatu, Departamento de Pediatria, Programa de Pós-graduação em Ginecologia, Obstetrícia e MastologiaUniversidade Estadual Paulista (UNESP), Faculdade de Medicina de Botucatu, Departamento de Pediatria, Centro de Pesquisa Pediátrica Clínica e ExperimentalUniversidade Norte do Paraná Departamento de Educação FísicaUniversidade Estadual Paulista (UNESP), Instituto de Biociências, Departamento de EstatísticaUniversidade Estadual Paulista (UNESP), Faculdade de Medicina de BotucatuUniversidade Estadual Paulista (UNESP), Faculdade de Medicina de Botucatu, Departamento de Pediatria, Programa de Pós-graduação em Ginecologia, Obstetrícia e MastologiaUniversidade Estadual Paulista (UNESP), Faculdade de Medicina de Botucatu, Departamento de Pediatria, Centro de Pesquisa Pediátrica Clínica e ExperimentalUniversidade Estadual Paulista (UNESP), Instituto de Biociências, Departamento de EstatísticaUniversidade Estadual Paulista (UNESP), Faculdade de Medicina de BotucatuUniversidade Estadual Paulista (Unesp)Universidade Norte do ParanáRizzo, Anapaula da Conceição Bisi [UNESP]Goldberg, Tamara Beres Lederer [UNESP]Biason, Talita Poli [UNESP]Kurokawa, Cilmery Suemi [UNESP]Silva, Carla Cristiane daCorrente, José Eduardo [UNESP]Nunes, Helio Rubens Carvalho [UNESP]2019-10-06T16:07:37Z2019-10-06T16:07:37Z2018-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://dx.doi.org/10.1016/j.jped.2018.05.011Jornal de Pediatria.0021-7557http://hdl.handle.net/11449/18842410.1016/j.jped.2018.05.011S0021-755720190006005672-s2.0-85057446320S0021-75572019000600567.pdf85104232695404650000-0003-1380-7527Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengporJornal de Pediatriainfo:eu-repo/semantics/openAccess2024-09-03T13:46:37Zoai:repositorio.unesp.br:11449/188424Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestrepositoriounesp@unesp.bropendoar:29462024-09-03T13:46:37Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
| dc.title.none.fl_str_mv |
One-year adolescent bone mineral density and bone formation marker changes through the use or lack of use of combined hormonal contraceptives Alterações na densidade mineral óssea e nos marcadores de formação óssea em adolescentes usuárias ou não de contraceptivos hormonais orais combinados por período de um ano |
| title |
One-year adolescent bone mineral density and bone formation marker changes through the use or lack of use of combined hormonal contraceptives |
| spellingShingle |
One-year adolescent bone mineral density and bone formation marker changes through the use or lack of use of combined hormonal contraceptives Rizzo, Anapaula da Conceição Bisi [UNESP] Adolescentes Adolescents Bone density Bone remodeling Contraceptivos orais Densidade óssea Estudo prospectivo Oral contraceptives Osteocalcin Osteocalcina Prospective study Remodelação óssea |
| title_short |
One-year adolescent bone mineral density and bone formation marker changes through the use or lack of use of combined hormonal contraceptives |
| title_full |
One-year adolescent bone mineral density and bone formation marker changes through the use or lack of use of combined hormonal contraceptives |
| title_fullStr |
One-year adolescent bone mineral density and bone formation marker changes through the use or lack of use of combined hormonal contraceptives |
| title_full_unstemmed |
One-year adolescent bone mineral density and bone formation marker changes through the use or lack of use of combined hormonal contraceptives |
| title_sort |
One-year adolescent bone mineral density and bone formation marker changes through the use or lack of use of combined hormonal contraceptives |
| author |
Rizzo, Anapaula da Conceição Bisi [UNESP] |
| author_facet |
Rizzo, Anapaula da Conceição Bisi [UNESP] Goldberg, Tamara Beres Lederer [UNESP] Biason, Talita Poli [UNESP] Kurokawa, Cilmery Suemi [UNESP] Silva, Carla Cristiane da Corrente, José Eduardo [UNESP] Nunes, Helio Rubens Carvalho [UNESP] |
| author_role |
author |
| author2 |
Goldberg, Tamara Beres Lederer [UNESP] Biason, Talita Poli [UNESP] Kurokawa, Cilmery Suemi [UNESP] Silva, Carla Cristiane da Corrente, José Eduardo [UNESP] Nunes, Helio Rubens Carvalho [UNESP] |
| author2_role |
author author author author author author |
| dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) Universidade Norte do Paraná |
| dc.contributor.author.fl_str_mv |
Rizzo, Anapaula da Conceição Bisi [UNESP] Goldberg, Tamara Beres Lederer [UNESP] Biason, Talita Poli [UNESP] Kurokawa, Cilmery Suemi [UNESP] Silva, Carla Cristiane da Corrente, José Eduardo [UNESP] Nunes, Helio Rubens Carvalho [UNESP] |
| dc.subject.por.fl_str_mv |
Adolescentes Adolescents Bone density Bone remodeling Contraceptivos orais Densidade óssea Estudo prospectivo Oral contraceptives Osteocalcin Osteocalcina Prospective study Remodelação óssea |
| topic |
Adolescentes Adolescents Bone density Bone remodeling Contraceptivos orais Densidade óssea Estudo prospectivo Oral contraceptives Osteocalcin Osteocalcina Prospective study Remodelação óssea |
| description |
Objective: The objective of this study was to evaluate the effects of two low-dose combined oral contraceptives on bone metabolism in adolescents for one year. Methods: This was a quasi-experimental study. The adolescents were divided into three groups: oral contraceptives 1 (n = 42) (20 μg EE/150 μg desogestrel), oral contraceptives 2 (n = 66) (30 μg EE/3 mg drospirenone), and a control group (n = 70). Adolescents underwent anthropometric assessment and densitometry (dual-energy X-ray). Bone age and bone formation markers (osteocalcin and bone alkaline phosphatase) were evaluated. The oral contraceptives users were evaluated again after 12 months. Linear regression analysis was used to indirectly study the effect of each additional year of chronological age on anthropometric and densitometric variables as well as on bone markers in the control group. Results: At study entry, no significant differences were observed between the oral contraceptives 1, oral contraceptives 2, and controls in the analyzed variables. Linear regression analysis showed an increase in bone mineral density and bone mineral content for each additional year. There was a significant reduction in bone alkaline phosphatase levels; no significant difference was observed for osteocalcin in control individuals. Comparison of dual-energy X-ray variables at baseline and after one year showed no significant differences in the oral contraceptives 1 or oral contraceptives 2 groups. A significant reduction in bone alkaline phosphatase and osteocalcin levels was observed in both the oral contraceptives 1 and oral contraceptives 2 groups. Conclusion: Adolescent women gain peak bone mass during this phase of life. Two low-dose combined oral hormonal contraceptives were associated with lower bone gain and lower bone formation markers than in untreated controls. |
| publishDate |
2018 |
| dc.date.none.fl_str_mv |
2018-01-01 2019-10-06T16:07:37Z 2019-10-06T16:07:37Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
| format |
article |
| status_str |
publishedVersion |
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http://dx.doi.org/10.1016/j.jped.2018.05.011 Jornal de Pediatria. 0021-7557 http://hdl.handle.net/11449/188424 10.1016/j.jped.2018.05.011 S0021-75572019000600567 2-s2.0-85057446320 S0021-75572019000600567.pdf 8510423269540465 0000-0003-1380-7527 |
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http://dx.doi.org/10.1016/j.jped.2018.05.011 http://hdl.handle.net/11449/188424 |
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Jornal de Pediatria. 0021-7557 10.1016/j.jped.2018.05.011 S0021-75572019000600567 2-s2.0-85057446320 S0021-75572019000600567.pdf 8510423269540465 0000-0003-1380-7527 |
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eng por |
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eng por |
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Jornal de Pediatria |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
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Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
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Universidade Estadual Paulista (UNESP) |
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UNESP |
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UNESP |
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Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
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1810021378986868736 |