Prenatal mold exposure is associated with development of atopic dermatitis in infants through allergic inflammation
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Jornal de Pediatria (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0021-75572020000100125 |
Resumo: | Abstract Objective Mold exposure in early life may be associated with development of atopic dermatitis; however, studies of this link are inconclusive and evidence for the underlying mechanism(s) is lacking. This study identified the association between the time of mold exposure and development of atopic dermatitis and investigated the underlying mechanisms. Method The association between atopic dermatitis and mold exposure was examined in the Cohort for Childhood Origin of Asthma and Allergic Diseases birth cohort study (n = 1446). Atopic dermatitis was diagnosed at 1 year of age by pediatric allergists. Exposure to mold was assessed by questionnaire. The Illumina MiSeq platform was used to examine the environmental mycobiome in 20 randomly selected healthy infants and 20 infants with atopic dermatitis at 36 weeks of gestation. Results Prenatal, but not postnatal, mold exposure was significantly associated with atopic dermatitis (adjusted odds ratio, 1.36; 95% confidence interval, 1.01-1.83). Levels of total serum IgE at 1 year of age were higher in infants with atopic dermatitis exposed to mold during pregnancy than in healthy infants not exposed to mold during pregnancy (p = 0.021). The relative abundance of uncultured Ascomycota was higher in infants with atopic dermatitis than in healthy infants. The relative abundance of uncultured Ascomycota correlated with total serum IgE levels at 1 year of age (r = 0.613, p < 0.001). Conclusion Indoor mold exposure during the fetal period is associated with development of atopic dermatitis via IgE-mediated allergic inflammation. Avoidance of mold exposure during this critical period might prevent the development of atopic dermatitis. |
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Prenatal mold exposure is associated with development of atopic dermatitis in infants through allergic inflammationAllergic inflammationAtopic dermatitisEnvironmentMoldMycobiomePrenatalAbstract Objective Mold exposure in early life may be associated with development of atopic dermatitis; however, studies of this link are inconclusive and evidence for the underlying mechanism(s) is lacking. This study identified the association between the time of mold exposure and development of atopic dermatitis and investigated the underlying mechanisms. Method The association between atopic dermatitis and mold exposure was examined in the Cohort for Childhood Origin of Asthma and Allergic Diseases birth cohort study (n = 1446). Atopic dermatitis was diagnosed at 1 year of age by pediatric allergists. Exposure to mold was assessed by questionnaire. The Illumina MiSeq platform was used to examine the environmental mycobiome in 20 randomly selected healthy infants and 20 infants with atopic dermatitis at 36 weeks of gestation. Results Prenatal, but not postnatal, mold exposure was significantly associated with atopic dermatitis (adjusted odds ratio, 1.36; 95% confidence interval, 1.01-1.83). Levels of total serum IgE at 1 year of age were higher in infants with atopic dermatitis exposed to mold during pregnancy than in healthy infants not exposed to mold during pregnancy (p = 0.021). The relative abundance of uncultured Ascomycota was higher in infants with atopic dermatitis than in healthy infants. The relative abundance of uncultured Ascomycota correlated with total serum IgE levels at 1 year of age (r = 0.613, p < 0.001). Conclusion Indoor mold exposure during the fetal period is associated with development of atopic dermatitis via IgE-mediated allergic inflammation. Avoidance of mold exposure during this critical period might prevent the development of atopic dermatitis.Sociedade Brasileira de Pediatria2020-02-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0021-75572020000100125Jornal de Pediatria v.96 n.1 2020reponame:Jornal de Pediatria (Online)instname:Sociedade Brasileira de Pediatria (SBP)instacron:SBPE10.1016/j.jped.2018.07.012info:eu-repo/semantics/openAccessLee,EunChoi,Kil YongKang,Mi-JinLee,So-YeonYoon,JisunCho,Hyun-JuJung,SungsuLee,Si HyeonSuh,Dong InShin,Youn HoKim,Kyung WonAhn,KangmoHong,Soo-Jongeng2020-02-28T00:00:00Zoai:scielo:S0021-75572020000100125Revistahttp://www.jped.com.br/https://old.scielo.br/oai/scielo-oai.php||jped@jped.com.br1678-47820021-7557opendoar:2020-02-28T00:00Jornal de Pediatria (Online) - Sociedade Brasileira de Pediatria (SBP)false |
dc.title.none.fl_str_mv |
Prenatal mold exposure is associated with development of atopic dermatitis in infants through allergic inflammation |
title |
Prenatal mold exposure is associated with development of atopic dermatitis in infants through allergic inflammation |
spellingShingle |
Prenatal mold exposure is associated with development of atopic dermatitis in infants through allergic inflammation Lee,Eun Allergic inflammation Atopic dermatitis Environment Mold Mycobiome Prenatal |
title_short |
Prenatal mold exposure is associated with development of atopic dermatitis in infants through allergic inflammation |
title_full |
Prenatal mold exposure is associated with development of atopic dermatitis in infants through allergic inflammation |
title_fullStr |
Prenatal mold exposure is associated with development of atopic dermatitis in infants through allergic inflammation |
title_full_unstemmed |
Prenatal mold exposure is associated with development of atopic dermatitis in infants through allergic inflammation |
title_sort |
Prenatal mold exposure is associated with development of atopic dermatitis in infants through allergic inflammation |
author |
Lee,Eun |
author_facet |
Lee,Eun Choi,Kil Yong Kang,Mi-Jin Lee,So-Yeon Yoon,Jisun Cho,Hyun-Ju Jung,Sungsu Lee,Si Hyeon Suh,Dong In Shin,Youn Ho Kim,Kyung Won Ahn,Kangmo Hong,Soo-Jong |
author_role |
author |
author2 |
Choi,Kil Yong Kang,Mi-Jin Lee,So-Yeon Yoon,Jisun Cho,Hyun-Ju Jung,Sungsu Lee,Si Hyeon Suh,Dong In Shin,Youn Ho Kim,Kyung Won Ahn,Kangmo Hong,Soo-Jong |
author2_role |
author author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Lee,Eun Choi,Kil Yong Kang,Mi-Jin Lee,So-Yeon Yoon,Jisun Cho,Hyun-Ju Jung,Sungsu Lee,Si Hyeon Suh,Dong In Shin,Youn Ho Kim,Kyung Won Ahn,Kangmo Hong,Soo-Jong |
dc.subject.por.fl_str_mv |
Allergic inflammation Atopic dermatitis Environment Mold Mycobiome Prenatal |
topic |
Allergic inflammation Atopic dermatitis Environment Mold Mycobiome Prenatal |
description |
Abstract Objective Mold exposure in early life may be associated with development of atopic dermatitis; however, studies of this link are inconclusive and evidence for the underlying mechanism(s) is lacking. This study identified the association between the time of mold exposure and development of atopic dermatitis and investigated the underlying mechanisms. Method The association between atopic dermatitis and mold exposure was examined in the Cohort for Childhood Origin of Asthma and Allergic Diseases birth cohort study (n = 1446). Atopic dermatitis was diagnosed at 1 year of age by pediatric allergists. Exposure to mold was assessed by questionnaire. The Illumina MiSeq platform was used to examine the environmental mycobiome in 20 randomly selected healthy infants and 20 infants with atopic dermatitis at 36 weeks of gestation. Results Prenatal, but not postnatal, mold exposure was significantly associated with atopic dermatitis (adjusted odds ratio, 1.36; 95% confidence interval, 1.01-1.83). Levels of total serum IgE at 1 year of age were higher in infants with atopic dermatitis exposed to mold during pregnancy than in healthy infants not exposed to mold during pregnancy (p = 0.021). The relative abundance of uncultured Ascomycota was higher in infants with atopic dermatitis than in healthy infants. The relative abundance of uncultured Ascomycota correlated with total serum IgE levels at 1 year of age (r = 0.613, p < 0.001). Conclusion Indoor mold exposure during the fetal period is associated with development of atopic dermatitis via IgE-mediated allergic inflammation. Avoidance of mold exposure during this critical period might prevent the development of atopic dermatitis. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-02-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0021-75572020000100125 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0021-75572020000100125 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1016/j.jped.2018.07.012 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Pediatria |
publisher.none.fl_str_mv |
Sociedade Brasileira de Pediatria |
dc.source.none.fl_str_mv |
Jornal de Pediatria v.96 n.1 2020 reponame:Jornal de Pediatria (Online) instname:Sociedade Brasileira de Pediatria (SBP) instacron:SBPE |
instname_str |
Sociedade Brasileira de Pediatria (SBP) |
instacron_str |
SBPE |
institution |
SBPE |
reponame_str |
Jornal de Pediatria (Online) |
collection |
Jornal de Pediatria (Online) |
repository.name.fl_str_mv |
Jornal de Pediatria (Online) - Sociedade Brasileira de Pediatria (SBP) |
repository.mail.fl_str_mv |
||jped@jped.com.br |
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1752122322244861952 |