Presence and duration of anti-Toxoplasma gondii immunoglobulin M in infants with congenital toxoplasmosis

Detalhes bibliográficos
Autor(a) principal: Lago,Eleonor G.
Data de Publicação: 2014
Outros Autores: Oliveira,Anna Paula, Bender,Ana Lígia
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Jornal de Pediatria (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0021-75572014000400363
Resumo: OBJECTIVES: to investigate the rate of positivity for immunoglobulin M anti-Toxoplasma gondii (Toxo-IgM) in newborns with congenital toxoplasmosis, and the age when these antibodies become negative. METHODS: patients with congenital toxoplasmosis who started monitoring in a congenital infection clinic between 1998 and 2009 were included. Inclusion criteria were routine maternal or neonatal serological screening; diagnostic confirmation by persistence of immunoglobulin G anti-Toxoplasma gondii at age > 12 months, and Toxo-IgM screening in the neonatal period. To calculate the frequency of positive Toxo-IgM, cases detected by neonatal screening were excluded. For the study of the age when Toxo-IgM results became negative, patients with negative Toxo-IgM since birth and those in whom it was not possible to identify the month when the negative result was achieved were excluded. RESULTS: among the 28 patients identified through maternal screening, 23 newborns had positive Toxo-IgM (82.1%, 95% CI: 64.7-93.1%). When adding the 37 patients identified by neonatal screening, Toxo-IgM was positive in the first month of life in 60 patients, and it was possible to identify when the result became negative in 51 of them. In 19.6% of patients, these antibodies were already negative at 30 days of life; and in 54.9%, at 90 days. Among the 65 patients included in the study, 40 (61.5%) had some clinical alteration. CONCLUSIONS: even with high sensitivity methods, newborns with congenital toxoplasmosis can have negative Toxo-IgM at birth. In those who have these antibodies, the positive period may be quite short. It is important not to interrupt the monitoring of infants with suspected congenital toxoplasmosis simply because they present a negative Toxo-IgM result.
id SBPE-1_c691d61ae4c339c42928b09126afd0bc
oai_identifier_str oai:scielo:S0021-75572014000400363
network_acronym_str SBPE-1
network_name_str Jornal de Pediatria (Online)
repository_id_str
spelling Presence and duration of anti-Toxoplasma gondii immunoglobulin M in infants with congenital toxoplasmosis Congenital toxoplasmosisToxoplasma gondiiImmunoglobulin M/ diagnostic useSerological testsNeonatal screeningVertical transmission of infectious disease OBJECTIVES: to investigate the rate of positivity for immunoglobulin M anti-Toxoplasma gondii (Toxo-IgM) in newborns with congenital toxoplasmosis, and the age when these antibodies become negative. METHODS: patients with congenital toxoplasmosis who started monitoring in a congenital infection clinic between 1998 and 2009 were included. Inclusion criteria were routine maternal or neonatal serological screening; diagnostic confirmation by persistence of immunoglobulin G anti-Toxoplasma gondii at age > 12 months, and Toxo-IgM screening in the neonatal period. To calculate the frequency of positive Toxo-IgM, cases detected by neonatal screening were excluded. For the study of the age when Toxo-IgM results became negative, patients with negative Toxo-IgM since birth and those in whom it was not possible to identify the month when the negative result was achieved were excluded. RESULTS: among the 28 patients identified through maternal screening, 23 newborns had positive Toxo-IgM (82.1%, 95% CI: 64.7-93.1%). When adding the 37 patients identified by neonatal screening, Toxo-IgM was positive in the first month of life in 60 patients, and it was possible to identify when the result became negative in 51 of them. In 19.6% of patients, these antibodies were already negative at 30 days of life; and in 54.9%, at 90 days. Among the 65 patients included in the study, 40 (61.5%) had some clinical alteration. CONCLUSIONS: even with high sensitivity methods, newborns with congenital toxoplasmosis can have negative Toxo-IgM at birth. In those who have these antibodies, the positive period may be quite short. It is important not to interrupt the monitoring of infants with suspected congenital toxoplasmosis simply because they present a negative Toxo-IgM result. Sociedade Brasileira de Pediatria2014-08-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0021-75572014000400363Jornal de Pediatria v.90 n.4 2014reponame:Jornal de Pediatria (Online)instname:Sociedade Brasileira de Pediatria (SBP)instacron:SBPE10.1016/j.jped.2013.12.006info:eu-repo/semantics/openAccessLago,Eleonor G.Oliveira,Anna PaulaBender,Ana Lígiaeng2015-08-25T00:00:00Zoai:scielo:S0021-75572014000400363Revistahttp://www.jped.com.br/https://old.scielo.br/oai/scielo-oai.php||jped@jped.com.br1678-47820021-7557opendoar:2015-08-25T00:00Jornal de Pediatria (Online) - Sociedade Brasileira de Pediatria (SBP)false
dc.title.none.fl_str_mv Presence and duration of anti-Toxoplasma gondii immunoglobulin M in infants with congenital toxoplasmosis
title Presence and duration of anti-Toxoplasma gondii immunoglobulin M in infants with congenital toxoplasmosis
spellingShingle Presence and duration of anti-Toxoplasma gondii immunoglobulin M in infants with congenital toxoplasmosis
Lago,Eleonor G.
Congenital toxoplasmosis
Toxoplasma gondii
Immunoglobulin M/ diagnostic use
Serological tests
Neonatal screening
Vertical transmission of infectious disease
title_short Presence and duration of anti-Toxoplasma gondii immunoglobulin M in infants with congenital toxoplasmosis
title_full Presence and duration of anti-Toxoplasma gondii immunoglobulin M in infants with congenital toxoplasmosis
title_fullStr Presence and duration of anti-Toxoplasma gondii immunoglobulin M in infants with congenital toxoplasmosis
title_full_unstemmed Presence and duration of anti-Toxoplasma gondii immunoglobulin M in infants with congenital toxoplasmosis
title_sort Presence and duration of anti-Toxoplasma gondii immunoglobulin M in infants with congenital toxoplasmosis
author Lago,Eleonor G.
author_facet Lago,Eleonor G.
Oliveira,Anna Paula
Bender,Ana Lígia
author_role author
author2 Oliveira,Anna Paula
Bender,Ana Lígia
author2_role author
author
dc.contributor.author.fl_str_mv Lago,Eleonor G.
Oliveira,Anna Paula
Bender,Ana Lígia
dc.subject.por.fl_str_mv Congenital toxoplasmosis
Toxoplasma gondii
Immunoglobulin M/ diagnostic use
Serological tests
Neonatal screening
Vertical transmission of infectious disease
topic Congenital toxoplasmosis
Toxoplasma gondii
Immunoglobulin M/ diagnostic use
Serological tests
Neonatal screening
Vertical transmission of infectious disease
description OBJECTIVES: to investigate the rate of positivity for immunoglobulin M anti-Toxoplasma gondii (Toxo-IgM) in newborns with congenital toxoplasmosis, and the age when these antibodies become negative. METHODS: patients with congenital toxoplasmosis who started monitoring in a congenital infection clinic between 1998 and 2009 were included. Inclusion criteria were routine maternal or neonatal serological screening; diagnostic confirmation by persistence of immunoglobulin G anti-Toxoplasma gondii at age > 12 months, and Toxo-IgM screening in the neonatal period. To calculate the frequency of positive Toxo-IgM, cases detected by neonatal screening were excluded. For the study of the age when Toxo-IgM results became negative, patients with negative Toxo-IgM since birth and those in whom it was not possible to identify the month when the negative result was achieved were excluded. RESULTS: among the 28 patients identified through maternal screening, 23 newborns had positive Toxo-IgM (82.1%, 95% CI: 64.7-93.1%). When adding the 37 patients identified by neonatal screening, Toxo-IgM was positive in the first month of life in 60 patients, and it was possible to identify when the result became negative in 51 of them. In 19.6% of patients, these antibodies were already negative at 30 days of life; and in 54.9%, at 90 days. Among the 65 patients included in the study, 40 (61.5%) had some clinical alteration. CONCLUSIONS: even with high sensitivity methods, newborns with congenital toxoplasmosis can have negative Toxo-IgM at birth. In those who have these antibodies, the positive period may be quite short. It is important not to interrupt the monitoring of infants with suspected congenital toxoplasmosis simply because they present a negative Toxo-IgM result.
publishDate 2014
dc.date.none.fl_str_mv 2014-08-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0021-75572014000400363
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0021-75572014000400363
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1016/j.jped.2013.12.006
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Pediatria
publisher.none.fl_str_mv Sociedade Brasileira de Pediatria
dc.source.none.fl_str_mv Jornal de Pediatria v.90 n.4 2014
reponame:Jornal de Pediatria (Online)
instname:Sociedade Brasileira de Pediatria (SBP)
instacron:SBPE
instname_str Sociedade Brasileira de Pediatria (SBP)
instacron_str SBPE
institution SBPE
reponame_str Jornal de Pediatria (Online)
collection Jornal de Pediatria (Online)
repository.name.fl_str_mv Jornal de Pediatria (Online) - Sociedade Brasileira de Pediatria (SBP)
repository.mail.fl_str_mv ||jped@jped.com.br
_version_ 1752122319960014848