Dendritic cells and their relation to apical peridontitis
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Brazilian Oral Research |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1806-83242018000500606 |
Resumo: | Abstract: The purpose of this manuscript was to re-discuss apical periodontitis, apical biofilm, and its possible relationship with dendritic cells (DC). DCs are potent regulators of the immune system and their function is divided into three categories that involve the presentation of antigens: the presentation of antigens and activation of T cells; a not well established category suggested that DCs induce and maintain immunological tolerance; and the maintenance of the immune memory in conjunction with B cells. DCs in periapical inflammatory lesions are composed of at least two subpopulations that can be distinguished on the basis of ultrastructure and phenotype. These populations might differ in lineage, state of maturation, differentiation, activation, and/or function. The authors hereby analyzed the root apexes of teeth under SEM, after performing apicoectomy due to the failure of conventional endodontic treatment. Microbial biofilm with multispecies and areas of resorption with the presence of Howship lacunae, and images suggestive of denditric cells could be observed. The presence of DCs in periapical lesion could be an indication of the severity of the lesion, with a constant presence of antigen in the periradicular region. |
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Dendritic cells and their relation to apical peridontitisDendritic CellsPeriapical PeriodontitisApicoectomyBiofilmsAbstract: The purpose of this manuscript was to re-discuss apical periodontitis, apical biofilm, and its possible relationship with dendritic cells (DC). DCs are potent regulators of the immune system and their function is divided into three categories that involve the presentation of antigens: the presentation of antigens and activation of T cells; a not well established category suggested that DCs induce and maintain immunological tolerance; and the maintenance of the immune memory in conjunction with B cells. DCs in periapical inflammatory lesions are composed of at least two subpopulations that can be distinguished on the basis of ultrastructure and phenotype. These populations might differ in lineage, state of maturation, differentiation, activation, and/or function. The authors hereby analyzed the root apexes of teeth under SEM, after performing apicoectomy due to the failure of conventional endodontic treatment. Microbial biofilm with multispecies and areas of resorption with the presence of Howship lacunae, and images suggestive of denditric cells could be observed. The presence of DCs in periapical lesion could be an indication of the severity of the lesion, with a constant presence of antigen in the periradicular region.Sociedade Brasileira de Pesquisa Odontológica - SBPqO2018-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1806-83242018000500606Brazilian Oral Research v.32 suppl.1 2018reponame:Brazilian Oral Researchinstname:Sociedade Brasileira de Pesquisa Odontológica (SBPqO)instacron:SBPQO10.1590/1807-3107bor-2018.vol32.0071info:eu-repo/semantics/openAccessFigueiredo,José Antonio Poli deMachado,Audrey MoraesOliveira,Vinícius Pasqualotti deHartmann,RafaelWaltrick,Silvana Beltrami GonçalvesBorba,Maristela Gutierrez deBrew,Myrian CâmaraEstrela,Cyntia Rodrigues de AraújoBöttcher,Daiana Elisabetheng2018-10-10T00:00:00Zoai:scielo:S1806-83242018000500606Revistahttps://www.scielo.br/j/bor/https://old.scielo.br/oai/scielo-oai.phppob@edu.usp.br||bor@sbpqo.org.br1807-31071806-8324opendoar:2018-10-10T00:00Brazilian Oral Research - Sociedade Brasileira de Pesquisa Odontológica (SBPqO)false |
dc.title.none.fl_str_mv |
Dendritic cells and their relation to apical peridontitis |
title |
Dendritic cells and their relation to apical peridontitis |
spellingShingle |
Dendritic cells and their relation to apical peridontitis Figueiredo,José Antonio Poli de Dendritic Cells Periapical Periodontitis Apicoectomy Biofilms |
title_short |
Dendritic cells and their relation to apical peridontitis |
title_full |
Dendritic cells and their relation to apical peridontitis |
title_fullStr |
Dendritic cells and their relation to apical peridontitis |
title_full_unstemmed |
Dendritic cells and their relation to apical peridontitis |
title_sort |
Dendritic cells and their relation to apical peridontitis |
author |
Figueiredo,José Antonio Poli de |
author_facet |
Figueiredo,José Antonio Poli de Machado,Audrey Moraes Oliveira,Vinícius Pasqualotti de Hartmann,Rafael Waltrick,Silvana Beltrami Gonçalves Borba,Maristela Gutierrez de Brew,Myrian Câmara Estrela,Cyntia Rodrigues de Araújo Böttcher,Daiana Elisabeth |
author_role |
author |
author2 |
Machado,Audrey Moraes Oliveira,Vinícius Pasqualotti de Hartmann,Rafael Waltrick,Silvana Beltrami Gonçalves Borba,Maristela Gutierrez de Brew,Myrian Câmara Estrela,Cyntia Rodrigues de Araújo Böttcher,Daiana Elisabeth |
author2_role |
author author author author author author author author |
dc.contributor.author.fl_str_mv |
Figueiredo,José Antonio Poli de Machado,Audrey Moraes Oliveira,Vinícius Pasqualotti de Hartmann,Rafael Waltrick,Silvana Beltrami Gonçalves Borba,Maristela Gutierrez de Brew,Myrian Câmara Estrela,Cyntia Rodrigues de Araújo Böttcher,Daiana Elisabeth |
dc.subject.por.fl_str_mv |
Dendritic Cells Periapical Periodontitis Apicoectomy Biofilms |
topic |
Dendritic Cells Periapical Periodontitis Apicoectomy Biofilms |
description |
Abstract: The purpose of this manuscript was to re-discuss apical periodontitis, apical biofilm, and its possible relationship with dendritic cells (DC). DCs are potent regulators of the immune system and their function is divided into three categories that involve the presentation of antigens: the presentation of antigens and activation of T cells; a not well established category suggested that DCs induce and maintain immunological tolerance; and the maintenance of the immune memory in conjunction with B cells. DCs in periapical inflammatory lesions are composed of at least two subpopulations that can be distinguished on the basis of ultrastructure and phenotype. These populations might differ in lineage, state of maturation, differentiation, activation, and/or function. The authors hereby analyzed the root apexes of teeth under SEM, after performing apicoectomy due to the failure of conventional endodontic treatment. Microbial biofilm with multispecies and areas of resorption with the presence of Howship lacunae, and images suggestive of denditric cells could be observed. The presence of DCs in periapical lesion could be an indication of the severity of the lesion, with a constant presence of antigen in the periradicular region. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1806-83242018000500606 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1806-83242018000500606 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/1807-3107bor-2018.vol32.0071 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Pesquisa Odontológica - SBPqO |
publisher.none.fl_str_mv |
Sociedade Brasileira de Pesquisa Odontológica - SBPqO |
dc.source.none.fl_str_mv |
Brazilian Oral Research v.32 suppl.1 2018 reponame:Brazilian Oral Research instname:Sociedade Brasileira de Pesquisa Odontológica (SBPqO) instacron:SBPQO |
instname_str |
Sociedade Brasileira de Pesquisa Odontológica (SBPqO) |
instacron_str |
SBPQO |
institution |
SBPQO |
reponame_str |
Brazilian Oral Research |
collection |
Brazilian Oral Research |
repository.name.fl_str_mv |
Brazilian Oral Research - Sociedade Brasileira de Pesquisa Odontológica (SBPqO) |
repository.mail.fl_str_mv |
pob@edu.usp.br||bor@sbpqo.org.br |
_version_ |
1750318326194634752 |