In vitro minocycline activity on superinfecting microorganisms isolated from chronic periodontitis patients

Detalhes bibliográficos
Autor(a) principal: Oliveira,Luciana Fernandes de
Data de Publicação: 2006
Outros Autores: Jorge,Antonio Olavo Cardoso, Santos,Silvana Soléo Ferreira dos
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Brazilian Oral Research
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1806-83242006000300004
Resumo: Chronic periodontitis is the most common type of periodontitis and it is associated with various species of microorganisms. Enteric rods, Pseudomonas, Staphyloccocus and Candida have been retrieved from periodontal pockets of patients with chronic periodontitis and correlated to cases of superinfection. Local or systemic antibiotic therapy is indicated to reinforce the effects of the conventional mechanical therapy. Minocycline has been suggested as one of the most effective drugs against periodontal pathogens. The aim of this work was to evaluate the minimal inhibitory concentration (MIC) of minocycline on superinfecting microorganisms isolated from the periodontal pocket and the oral cavity of individuals with chronic periodontitis. Isolates of Enterobacteriaceae (n = 25), Staphylococcus spp. (n = 25), Pseudomonas aeruginosa (n = 9) and Candida spp. (n = 25) were included in the study. Minimal inhibitory concentrations (MIC) of minocycline were determined using the Müeller-Hinton agar dilution method. Staphylococcus spp. isolates were the most sensitive to minocycline with a MIC of 8 µg/mL, followed by Enterobacteriaceae with a MIC of 16 µg/mL. The concentration of 16 µg/mL inhibited 96% of Candida spp. isolates. The MIC for 88.8% of the isolates of Pseudomonas aeruginosa was 128 µg/mL. A concentration of 1,000 µg/mL was not enough to inhibit 100% of the tested isolates.
id SBPQO-1_202af3002013d31b99766871f7f978c6
oai_identifier_str oai:scielo:S1806-83242006000300004
network_acronym_str SBPQO-1
network_name_str Brazilian Oral Research
repository_id_str
spelling In vitro minocycline activity on superinfecting microorganisms isolated from chronic periodontitis patientsPeriodontitisMinocyclineMinimum inhibitory concentrationChronic periodontitis is the most common type of periodontitis and it is associated with various species of microorganisms. Enteric rods, Pseudomonas, Staphyloccocus and Candida have been retrieved from periodontal pockets of patients with chronic periodontitis and correlated to cases of superinfection. Local or systemic antibiotic therapy is indicated to reinforce the effects of the conventional mechanical therapy. Minocycline has been suggested as one of the most effective drugs against periodontal pathogens. The aim of this work was to evaluate the minimal inhibitory concentration (MIC) of minocycline on superinfecting microorganisms isolated from the periodontal pocket and the oral cavity of individuals with chronic periodontitis. Isolates of Enterobacteriaceae (n = 25), Staphylococcus spp. (n = 25), Pseudomonas aeruginosa (n = 9) and Candida spp. (n = 25) were included in the study. Minimal inhibitory concentrations (MIC) of minocycline were determined using the Müeller-Hinton agar dilution method. Staphylococcus spp. isolates were the most sensitive to minocycline with a MIC of 8 µg/mL, followed by Enterobacteriaceae with a MIC of 16 µg/mL. The concentration of 16 µg/mL inhibited 96% of Candida spp. isolates. The MIC for 88.8% of the isolates of Pseudomonas aeruginosa was 128 µg/mL. A concentration of 1,000 µg/mL was not enough to inhibit 100% of the tested isolates.Sociedade Brasileira de Pesquisa Odontológica - SBPqO2006-09-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1806-83242006000300004Brazilian Oral Research v.20 n.3 2006reponame:Brazilian Oral Researchinstname:Sociedade Brasileira de Pesquisa Odontológica (SBPqO)instacron:SBPQO10.1590/S1806-83242006000300004info:eu-repo/semantics/openAccessOliveira,Luciana Fernandes deJorge,Antonio Olavo CardosoSantos,Silvana Soléo Ferreira doseng2006-10-10T00:00:00Zoai:scielo:S1806-83242006000300004Revistahttps://www.scielo.br/j/bor/https://old.scielo.br/oai/scielo-oai.phppob@edu.usp.br||bor@sbpqo.org.br1807-31071806-8324opendoar:2006-10-10T00:00Brazilian Oral Research - Sociedade Brasileira de Pesquisa Odontológica (SBPqO)false
dc.title.none.fl_str_mv In vitro minocycline activity on superinfecting microorganisms isolated from chronic periodontitis patients
title In vitro minocycline activity on superinfecting microorganisms isolated from chronic periodontitis patients
spellingShingle In vitro minocycline activity on superinfecting microorganisms isolated from chronic periodontitis patients
Oliveira,Luciana Fernandes de
Periodontitis
Minocycline
Minimum inhibitory concentration
title_short In vitro minocycline activity on superinfecting microorganisms isolated from chronic periodontitis patients
title_full In vitro minocycline activity on superinfecting microorganisms isolated from chronic periodontitis patients
title_fullStr In vitro minocycline activity on superinfecting microorganisms isolated from chronic periodontitis patients
title_full_unstemmed In vitro minocycline activity on superinfecting microorganisms isolated from chronic periodontitis patients
title_sort In vitro minocycline activity on superinfecting microorganisms isolated from chronic periodontitis patients
author Oliveira,Luciana Fernandes de
author_facet Oliveira,Luciana Fernandes de
Jorge,Antonio Olavo Cardoso
Santos,Silvana Soléo Ferreira dos
author_role author
author2 Jorge,Antonio Olavo Cardoso
Santos,Silvana Soléo Ferreira dos
author2_role author
author
dc.contributor.author.fl_str_mv Oliveira,Luciana Fernandes de
Jorge,Antonio Olavo Cardoso
Santos,Silvana Soléo Ferreira dos
dc.subject.por.fl_str_mv Periodontitis
Minocycline
Minimum inhibitory concentration
topic Periodontitis
Minocycline
Minimum inhibitory concentration
description Chronic periodontitis is the most common type of periodontitis and it is associated with various species of microorganisms. Enteric rods, Pseudomonas, Staphyloccocus and Candida have been retrieved from periodontal pockets of patients with chronic periodontitis and correlated to cases of superinfection. Local or systemic antibiotic therapy is indicated to reinforce the effects of the conventional mechanical therapy. Minocycline has been suggested as one of the most effective drugs against periodontal pathogens. The aim of this work was to evaluate the minimal inhibitory concentration (MIC) of minocycline on superinfecting microorganisms isolated from the periodontal pocket and the oral cavity of individuals with chronic periodontitis. Isolates of Enterobacteriaceae (n = 25), Staphylococcus spp. (n = 25), Pseudomonas aeruginosa (n = 9) and Candida spp. (n = 25) were included in the study. Minimal inhibitory concentrations (MIC) of minocycline were determined using the Müeller-Hinton agar dilution method. Staphylococcus spp. isolates were the most sensitive to minocycline with a MIC of 8 µg/mL, followed by Enterobacteriaceae with a MIC of 16 µg/mL. The concentration of 16 µg/mL inhibited 96% of Candida spp. isolates. The MIC for 88.8% of the isolates of Pseudomonas aeruginosa was 128 µg/mL. A concentration of 1,000 µg/mL was not enough to inhibit 100% of the tested isolates.
publishDate 2006
dc.date.none.fl_str_mv 2006-09-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1806-83242006000300004
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1806-83242006000300004
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S1806-83242006000300004
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Pesquisa Odontológica - SBPqO
publisher.none.fl_str_mv Sociedade Brasileira de Pesquisa Odontológica - SBPqO
dc.source.none.fl_str_mv Brazilian Oral Research v.20 n.3 2006
reponame:Brazilian Oral Research
instname:Sociedade Brasileira de Pesquisa Odontológica (SBPqO)
instacron:SBPQO
instname_str Sociedade Brasileira de Pesquisa Odontológica (SBPqO)
instacron_str SBPQO
institution SBPQO
reponame_str Brazilian Oral Research
collection Brazilian Oral Research
repository.name.fl_str_mv Brazilian Oral Research - Sociedade Brasileira de Pesquisa Odontológica (SBPqO)
repository.mail.fl_str_mv pob@edu.usp.br||bor@sbpqo.org.br
_version_ 1750318320769302528