Coexpression of p53 and Ki 67 and lack of c-erbB2 expression in oral leukoplakias in India

Detalhes bibliográficos
Autor(a) principal: Kumar,Priya
Data de Publicação: 2012
Outros Autores: Kane,Shubhada, Rathod,Govind Pomaji
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Brazilian Oral Research
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1806-83242012000300008
Resumo: Oral cancer is commonly preceded by premalignant lesions and conditions. The clinician's ability to identify lesions at an increased risk of cancer development is critical for its control. The purpose of this study was to compare the expression of tumor suppressor gene p53, proliferation marker Ki-67, and oncogene c-erbB2 and to evaluate the relevance of their co-expression in the diagnosis of, and prognosis for, oral leukoplakia. In the present study, the expression of biomarkers was studied immunohistochemically in 55 cases of leukoplakia (26 without dysplasia, 29 with dysplasia) and 10 cases of normal epithelia. The Labeling Indices (LI) of p53 and Ki-67 were found to increase significantly with an increase in the grade of dysplasia. A significant correlation was also found between the LI of p53 and that of Ki-67. It was also observed that c-erbB2 expression was only cytoplasmic, indicating incomplete receptor degradation. Hence, it can be concluded from the present study that the increased expression of p53 and Ki-67 with an increase in the grade of dysplasia suggests that their co-expression may be used for the identification of high-risk lesions. Also, c-erbB2 has no pathogenetic role in early carcinogenesis in the studied population, although incomplete receptor degradation, as evidenced by cytoplasmic staining, may indicate an early change.
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spelling Coexpression of p53 and Ki 67 and lack of c-erbB2 expression in oral leukoplakias in IndiaLeukoplakiaImmunohistochemistryMouth EoplasmsOncogenesTumor Suppressor Protein p53Oral cancer is commonly preceded by premalignant lesions and conditions. The clinician's ability to identify lesions at an increased risk of cancer development is critical for its control. The purpose of this study was to compare the expression of tumor suppressor gene p53, proliferation marker Ki-67, and oncogene c-erbB2 and to evaluate the relevance of their co-expression in the diagnosis of, and prognosis for, oral leukoplakia. In the present study, the expression of biomarkers was studied immunohistochemically in 55 cases of leukoplakia (26 without dysplasia, 29 with dysplasia) and 10 cases of normal epithelia. The Labeling Indices (LI) of p53 and Ki-67 were found to increase significantly with an increase in the grade of dysplasia. A significant correlation was also found between the LI of p53 and that of Ki-67. It was also observed that c-erbB2 expression was only cytoplasmic, indicating incomplete receptor degradation. Hence, it can be concluded from the present study that the increased expression of p53 and Ki-67 with an increase in the grade of dysplasia suggests that their co-expression may be used for the identification of high-risk lesions. Also, c-erbB2 has no pathogenetic role in early carcinogenesis in the studied population, although incomplete receptor degradation, as evidenced by cytoplasmic staining, may indicate an early change.Sociedade Brasileira de Pesquisa Odontológica - SBPqO2012-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1806-83242012000300008Brazilian Oral Research v.26 n.3 2012reponame:Brazilian Oral Researchinstname:Sociedade Brasileira de Pesquisa Odontológica (SBPqO)instacron:SBPQO10.1590/S1806-83242012000300008info:eu-repo/semantics/openAccessKumar,PriyaKane,ShubhadaRathod,Govind Pomajieng2012-05-23T00:00:00Zoai:scielo:S1806-83242012000300008Revistahttps://www.scielo.br/j/bor/https://old.scielo.br/oai/scielo-oai.phppob@edu.usp.br||bor@sbpqo.org.br1807-31071806-8324opendoar:2012-05-23T00:00Brazilian Oral Research - Sociedade Brasileira de Pesquisa Odontológica (SBPqO)false
dc.title.none.fl_str_mv Coexpression of p53 and Ki 67 and lack of c-erbB2 expression in oral leukoplakias in India
title Coexpression of p53 and Ki 67 and lack of c-erbB2 expression in oral leukoplakias in India
spellingShingle Coexpression of p53 and Ki 67 and lack of c-erbB2 expression in oral leukoplakias in India
Kumar,Priya
Leukoplakia
Immunohistochemistry
Mouth Eoplasms
Oncogenes
Tumor Suppressor Protein p53
title_short Coexpression of p53 and Ki 67 and lack of c-erbB2 expression in oral leukoplakias in India
title_full Coexpression of p53 and Ki 67 and lack of c-erbB2 expression in oral leukoplakias in India
title_fullStr Coexpression of p53 and Ki 67 and lack of c-erbB2 expression in oral leukoplakias in India
title_full_unstemmed Coexpression of p53 and Ki 67 and lack of c-erbB2 expression in oral leukoplakias in India
title_sort Coexpression of p53 and Ki 67 and lack of c-erbB2 expression in oral leukoplakias in India
author Kumar,Priya
author_facet Kumar,Priya
Kane,Shubhada
Rathod,Govind Pomaji
author_role author
author2 Kane,Shubhada
Rathod,Govind Pomaji
author2_role author
author
dc.contributor.author.fl_str_mv Kumar,Priya
Kane,Shubhada
Rathod,Govind Pomaji
dc.subject.por.fl_str_mv Leukoplakia
Immunohistochemistry
Mouth Eoplasms
Oncogenes
Tumor Suppressor Protein p53
topic Leukoplakia
Immunohistochemistry
Mouth Eoplasms
Oncogenes
Tumor Suppressor Protein p53
description Oral cancer is commonly preceded by premalignant lesions and conditions. The clinician's ability to identify lesions at an increased risk of cancer development is critical for its control. The purpose of this study was to compare the expression of tumor suppressor gene p53, proliferation marker Ki-67, and oncogene c-erbB2 and to evaluate the relevance of their co-expression in the diagnosis of, and prognosis for, oral leukoplakia. In the present study, the expression of biomarkers was studied immunohistochemically in 55 cases of leukoplakia (26 without dysplasia, 29 with dysplasia) and 10 cases of normal epithelia. The Labeling Indices (LI) of p53 and Ki-67 were found to increase significantly with an increase in the grade of dysplasia. A significant correlation was also found between the LI of p53 and that of Ki-67. It was also observed that c-erbB2 expression was only cytoplasmic, indicating incomplete receptor degradation. Hence, it can be concluded from the present study that the increased expression of p53 and Ki-67 with an increase in the grade of dysplasia suggests that their co-expression may be used for the identification of high-risk lesions. Also, c-erbB2 has no pathogenetic role in early carcinogenesis in the studied population, although incomplete receptor degradation, as evidenced by cytoplasmic staining, may indicate an early change.
publishDate 2012
dc.date.none.fl_str_mv 2012-06-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
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dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1806-83242012000300008
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dc.language.iso.fl_str_mv eng
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dc.relation.none.fl_str_mv 10.1590/S1806-83242012000300008
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dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Pesquisa Odontológica - SBPqO
publisher.none.fl_str_mv Sociedade Brasileira de Pesquisa Odontológica - SBPqO
dc.source.none.fl_str_mv Brazilian Oral Research v.26 n.3 2012
reponame:Brazilian Oral Research
instname:Sociedade Brasileira de Pesquisa Odontológica (SBPqO)
instacron:SBPQO
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reponame_str Brazilian Oral Research
collection Brazilian Oral Research
repository.name.fl_str_mv Brazilian Oral Research - Sociedade Brasileira de Pesquisa Odontológica (SBPqO)
repository.mail.fl_str_mv pob@edu.usp.br||bor@sbpqo.org.br
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