Evaluation of the effect of an organic extract obtained from Ipomoea alba L. on experimental periodontitis in rats
Autor(a) principal: | |
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Data de Publicação: | 2012 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Brazilian Oral Research |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1806-83242012000200012 |
Resumo: | The aim of this study was to evaluate the effect of an organic extract obtained from Ipomoea alba L. (Convolvulaceae or OE 1493), on experimental periodontal disease in rats. Periodontitis was induced in thirty six Wistar rats: a first mandibular molar was randomly assigned to receive a ligature, whereas the contralateral molar was left unligated. Animals were randomly assigned to two groups and treated topically, three times a day, for 11 days, as follows: Control Group - vehicle-treated (n = 18), and Test Group - OE 1493-treated (n = 18). The rats were sacrificed on the 12th day. Morphometrical measurements from the cementoenamel junction to the bone crest were performed to determine alveolar bone loss, using standardized photographs. Single- and multi-dose acute toxicity assays were carried out after OE 1493 treatment. Morphometrical analysis demonstrated that topically-administered OE 1493 showed no effect on reducing bone loss when compared with the control group (p > 0.05). In addition, OE 1493 did not present toxicity. Within the limits of this investigation, it may be concluded that OE 1493 did not show any positive influence on the progression of ligature-induced periodontitis in rats, when administered according to the regimen used in the present study. |
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Evaluation of the effect of an organic extract obtained from Ipomoea alba L. on experimental periodontitis in ratsDrug ToxicityPeriodontitisRatsAdministration, TopicalAnti-Bacterial AgentsThe aim of this study was to evaluate the effect of an organic extract obtained from Ipomoea alba L. (Convolvulaceae or OE 1493), on experimental periodontal disease in rats. Periodontitis was induced in thirty six Wistar rats: a first mandibular molar was randomly assigned to receive a ligature, whereas the contralateral molar was left unligated. Animals were randomly assigned to two groups and treated topically, three times a day, for 11 days, as follows: Control Group - vehicle-treated (n = 18), and Test Group - OE 1493-treated (n = 18). The rats were sacrificed on the 12th day. Morphometrical measurements from the cementoenamel junction to the bone crest were performed to determine alveolar bone loss, using standardized photographs. Single- and multi-dose acute toxicity assays were carried out after OE 1493 treatment. Morphometrical analysis demonstrated that topically-administered OE 1493 showed no effect on reducing bone loss when compared with the control group (p > 0.05). In addition, OE 1493 did not present toxicity. Within the limits of this investigation, it may be concluded that OE 1493 did not show any positive influence on the progression of ligature-induced periodontitis in rats, when administered according to the regimen used in the present study.Sociedade Brasileira de Pesquisa Odontológica - SBPqO2012-04-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1806-83242012000200012Brazilian Oral Research v.26 n.2 2012reponame:Brazilian Oral Researchinstname:Sociedade Brasileira de Pesquisa Odontológica (SBPqO)instacron:SBPQO10.1590/S1806-83242012000200012info:eu-repo/semantics/openAccessBarrella,Guilherme EmersonSuffredini,Ivana BarbosaRibeiro,Fernanda VieiraCirano,Fabiano RibeiroPimentel,Suzana Pereseng2012-04-10T00:00:00Zoai:scielo:S1806-83242012000200012Revistahttps://www.scielo.br/j/bor/https://old.scielo.br/oai/scielo-oai.phppob@edu.usp.br||bor@sbpqo.org.br1807-31071806-8324opendoar:2012-04-10T00:00Brazilian Oral Research - Sociedade Brasileira de Pesquisa Odontológica (SBPqO)false |
dc.title.none.fl_str_mv |
Evaluation of the effect of an organic extract obtained from Ipomoea alba L. on experimental periodontitis in rats |
title |
Evaluation of the effect of an organic extract obtained from Ipomoea alba L. on experimental periodontitis in rats |
spellingShingle |
Evaluation of the effect of an organic extract obtained from Ipomoea alba L. on experimental periodontitis in rats Barrella,Guilherme Emerson Drug Toxicity Periodontitis Rats Administration, Topical Anti-Bacterial Agents |
title_short |
Evaluation of the effect of an organic extract obtained from Ipomoea alba L. on experimental periodontitis in rats |
title_full |
Evaluation of the effect of an organic extract obtained from Ipomoea alba L. on experimental periodontitis in rats |
title_fullStr |
Evaluation of the effect of an organic extract obtained from Ipomoea alba L. on experimental periodontitis in rats |
title_full_unstemmed |
Evaluation of the effect of an organic extract obtained from Ipomoea alba L. on experimental periodontitis in rats |
title_sort |
Evaluation of the effect of an organic extract obtained from Ipomoea alba L. on experimental periodontitis in rats |
author |
Barrella,Guilherme Emerson |
author_facet |
Barrella,Guilherme Emerson Suffredini,Ivana Barbosa Ribeiro,Fernanda Vieira Cirano,Fabiano Ribeiro Pimentel,Suzana Peres |
author_role |
author |
author2 |
Suffredini,Ivana Barbosa Ribeiro,Fernanda Vieira Cirano,Fabiano Ribeiro Pimentel,Suzana Peres |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Barrella,Guilherme Emerson Suffredini,Ivana Barbosa Ribeiro,Fernanda Vieira Cirano,Fabiano Ribeiro Pimentel,Suzana Peres |
dc.subject.por.fl_str_mv |
Drug Toxicity Periodontitis Rats Administration, Topical Anti-Bacterial Agents |
topic |
Drug Toxicity Periodontitis Rats Administration, Topical Anti-Bacterial Agents |
description |
The aim of this study was to evaluate the effect of an organic extract obtained from Ipomoea alba L. (Convolvulaceae or OE 1493), on experimental periodontal disease in rats. Periodontitis was induced in thirty six Wistar rats: a first mandibular molar was randomly assigned to receive a ligature, whereas the contralateral molar was left unligated. Animals were randomly assigned to two groups and treated topically, three times a day, for 11 days, as follows: Control Group - vehicle-treated (n = 18), and Test Group - OE 1493-treated (n = 18). The rats were sacrificed on the 12th day. Morphometrical measurements from the cementoenamel junction to the bone crest were performed to determine alveolar bone loss, using standardized photographs. Single- and multi-dose acute toxicity assays were carried out after OE 1493 treatment. Morphometrical analysis demonstrated that topically-administered OE 1493 showed no effect on reducing bone loss when compared with the control group (p > 0.05). In addition, OE 1493 did not present toxicity. Within the limits of this investigation, it may be concluded that OE 1493 did not show any positive influence on the progression of ligature-induced periodontitis in rats, when administered according to the regimen used in the present study. |
publishDate |
2012 |
dc.date.none.fl_str_mv |
2012-04-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1806-83242012000200012 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1806-83242012000200012 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S1806-83242012000200012 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Pesquisa Odontológica - SBPqO |
publisher.none.fl_str_mv |
Sociedade Brasileira de Pesquisa Odontológica - SBPqO |
dc.source.none.fl_str_mv |
Brazilian Oral Research v.26 n.2 2012 reponame:Brazilian Oral Research instname:Sociedade Brasileira de Pesquisa Odontológica (SBPqO) instacron:SBPQO |
instname_str |
Sociedade Brasileira de Pesquisa Odontológica (SBPqO) |
instacron_str |
SBPQO |
institution |
SBPQO |
reponame_str |
Brazilian Oral Research |
collection |
Brazilian Oral Research |
repository.name.fl_str_mv |
Brazilian Oral Research - Sociedade Brasileira de Pesquisa Odontológica (SBPqO) |
repository.mail.fl_str_mv |
pob@edu.usp.br||bor@sbpqo.org.br |
_version_ |
1750318322585436160 |