A prospective randomized trial to reduce oral Candida spp. colonization in patients with hyposalivation
Autor(a) principal: | |
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Data de Publicação: | 2007 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Brazilian Oral Research |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1806-83242007000200015 |
Resumo: | Low salivary flow rates are associated with higher oral Candida spp. counts, which may predispose to oral candidiasis. The aim of this study was to compare the effect of stimulating salivary flow rates with that of a regimen of chlorhexidine mouth rinse on the intensity of Candida colonization in patients with reduced salivary flow rates. Thirty-one outpatients were randomized to stimulate salivary output (group 1) or to receive chlorhexidine mouth rinses (group 2). Evaluations were performed at baseline (T0), at end of treatment (T1), and 15 days after last day of treatment (T2). Chewing-stimulated whole saliva samples were collected at each visit. Group 1 showed a constant reduction in median cfu counts, although the difference was significant only between T0 and T2 (p = 0.004). Group 2 showed a reduction in median Candida cfu counts between T0 and T1 (p = 0.01), but the counts increased at T2 (p = 0.01), and the difference between T0 and T2 was not significant (p = 0.8). In conclusion, patients who received salivary stimulation showed reductions of Candida cfu counts in saliva and a trend for increasing salivary flow rates between baseline and end of study evaluations. The use of chlorhexidine mouth rinses dramatically reduced Candida cfu counts, but when patients discontinued treatment, intensity of colonization rose again. |
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A prospective randomized trial to reduce oral Candida spp. colonization in patients with hyposalivationSalivaCandidaXerostomiaHomeostasisColony count, microbialLow salivary flow rates are associated with higher oral Candida spp. counts, which may predispose to oral candidiasis. The aim of this study was to compare the effect of stimulating salivary flow rates with that of a regimen of chlorhexidine mouth rinse on the intensity of Candida colonization in patients with reduced salivary flow rates. Thirty-one outpatients were randomized to stimulate salivary output (group 1) or to receive chlorhexidine mouth rinses (group 2). Evaluations were performed at baseline (T0), at end of treatment (T1), and 15 days after last day of treatment (T2). Chewing-stimulated whole saliva samples were collected at each visit. Group 1 showed a constant reduction in median cfu counts, although the difference was significant only between T0 and T2 (p = 0.004). Group 2 showed a reduction in median Candida cfu counts between T0 and T1 (p = 0.01), but the counts increased at T2 (p = 0.01), and the difference between T0 and T2 was not significant (p = 0.8). In conclusion, patients who received salivary stimulation showed reductions of Candida cfu counts in saliva and a trend for increasing salivary flow rates between baseline and end of study evaluations. The use of chlorhexidine mouth rinses dramatically reduced Candida cfu counts, but when patients discontinued treatment, intensity of colonization rose again.Sociedade Brasileira de Pesquisa Odontológica - SBPqO2007-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1806-83242007000200015Brazilian Oral Research v.21 n.2 2007reponame:Brazilian Oral Researchinstname:Sociedade Brasileira de Pesquisa Odontológica (SBPqO)instacron:SBPQO10.1590/S1806-83242007000200015info:eu-repo/semantics/openAccessTorres,Sandra ReginaPeixoto,Camila BernardoCaldas,Daniele ManhãesAkiti,TiyomiBarreiros,Maria Glória CarvalhoUzeda,Milton deNucci,Marcioeng2009-10-19T00:00:00Zoai:scielo:S1806-83242007000200015Revistahttps://www.scielo.br/j/bor/https://old.scielo.br/oai/scielo-oai.phppob@edu.usp.br||bor@sbpqo.org.br1807-31071806-8324opendoar:2009-10-19T00:00Brazilian Oral Research - Sociedade Brasileira de Pesquisa Odontológica (SBPqO)false |
dc.title.none.fl_str_mv |
A prospective randomized trial to reduce oral Candida spp. colonization in patients with hyposalivation |
title |
A prospective randomized trial to reduce oral Candida spp. colonization in patients with hyposalivation |
spellingShingle |
A prospective randomized trial to reduce oral Candida spp. colonization in patients with hyposalivation Torres,Sandra Regina Saliva Candida Xerostomia Homeostasis Colony count, microbial |
title_short |
A prospective randomized trial to reduce oral Candida spp. colonization in patients with hyposalivation |
title_full |
A prospective randomized trial to reduce oral Candida spp. colonization in patients with hyposalivation |
title_fullStr |
A prospective randomized trial to reduce oral Candida spp. colonization in patients with hyposalivation |
title_full_unstemmed |
A prospective randomized trial to reduce oral Candida spp. colonization in patients with hyposalivation |
title_sort |
A prospective randomized trial to reduce oral Candida spp. colonization in patients with hyposalivation |
author |
Torres,Sandra Regina |
author_facet |
Torres,Sandra Regina Peixoto,Camila Bernardo Caldas,Daniele Manhães Akiti,Tiyomi Barreiros,Maria Glória Carvalho Uzeda,Milton de Nucci,Marcio |
author_role |
author |
author2 |
Peixoto,Camila Bernardo Caldas,Daniele Manhães Akiti,Tiyomi Barreiros,Maria Glória Carvalho Uzeda,Milton de Nucci,Marcio |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Torres,Sandra Regina Peixoto,Camila Bernardo Caldas,Daniele Manhães Akiti,Tiyomi Barreiros,Maria Glória Carvalho Uzeda,Milton de Nucci,Marcio |
dc.subject.por.fl_str_mv |
Saliva Candida Xerostomia Homeostasis Colony count, microbial |
topic |
Saliva Candida Xerostomia Homeostasis Colony count, microbial |
description |
Low salivary flow rates are associated with higher oral Candida spp. counts, which may predispose to oral candidiasis. The aim of this study was to compare the effect of stimulating salivary flow rates with that of a regimen of chlorhexidine mouth rinse on the intensity of Candida colonization in patients with reduced salivary flow rates. Thirty-one outpatients were randomized to stimulate salivary output (group 1) or to receive chlorhexidine mouth rinses (group 2). Evaluations were performed at baseline (T0), at end of treatment (T1), and 15 days after last day of treatment (T2). Chewing-stimulated whole saliva samples were collected at each visit. Group 1 showed a constant reduction in median cfu counts, although the difference was significant only between T0 and T2 (p = 0.004). Group 2 showed a reduction in median Candida cfu counts between T0 and T1 (p = 0.01), but the counts increased at T2 (p = 0.01), and the difference between T0 and T2 was not significant (p = 0.8). In conclusion, patients who received salivary stimulation showed reductions of Candida cfu counts in saliva and a trend for increasing salivary flow rates between baseline and end of study evaluations. The use of chlorhexidine mouth rinses dramatically reduced Candida cfu counts, but when patients discontinued treatment, intensity of colonization rose again. |
publishDate |
2007 |
dc.date.none.fl_str_mv |
2007-06-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1806-83242007000200015 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1806-83242007000200015 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S1806-83242007000200015 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Pesquisa Odontológica - SBPqO |
publisher.none.fl_str_mv |
Sociedade Brasileira de Pesquisa Odontológica - SBPqO |
dc.source.none.fl_str_mv |
Brazilian Oral Research v.21 n.2 2007 reponame:Brazilian Oral Research instname:Sociedade Brasileira de Pesquisa Odontológica (SBPqO) instacron:SBPQO |
instname_str |
Sociedade Brasileira de Pesquisa Odontológica (SBPqO) |
instacron_str |
SBPQO |
institution |
SBPQO |
reponame_str |
Brazilian Oral Research |
collection |
Brazilian Oral Research |
repository.name.fl_str_mv |
Brazilian Oral Research - Sociedade Brasileira de Pesquisa Odontológica (SBPqO) |
repository.mail.fl_str_mv |
pob@edu.usp.br||bor@sbpqo.org.br |
_version_ |
1750318320860528640 |